Member » Vice-President

Vice President Lu-Hai Wang

Vice President Lu-Hai Wang

Vice President Lu-Hai Wang


  • TEL: +886-4-22053366 ext. 1011 or 1013
  • Fax: +886-4-22952121
  • E-mail:
  • Secretary: Yi-Ling Wang/ Yi-Ying Wu


Current Position

  • Vice President & Chair Professor, China Medical University (Taiwan) , 2017/02
  • Academician, Academia Sinica (Taiwan), 1994



Year Education
1966-1970 National Taiwan University.  B.S. in Zoology
1971-1976 University of California at Berkeley.  Ph.D. in Molecular Biology


Position and Scientific Experience

Year Position and Scientific Experience
1966-1970 Undergraduate, College of Sciences, National Taiwan University,  Taiwan (Zoology, Chemistry).
Summer 1971 Research Assistant, Laboratory of Dr. Richard Calendar, Department of Molecular Biology, University of California at Berkeley: growth, quantitative assay and purification of bacteria and bacteriophages P2 and P4
1971-1976 Graduate Research, Department of Molecular Biology, University of California at Berkeley
1972-1976 Graduate Student, Laboratory of Dr. Peter Duesberg, Department of Molecular Biology, University of California at Berkeley.  Genetic structure and enzymology of RNA tumor viruses
1976-1977 Postgraduate Research Molecular Biologist, Laboratory of Dr. Peter Duesberg.  Sequences and functions of avian tumor virus RNAs; mechanism of viral recombination
1977-1979 Postdoctoral Fellow, Laboratory of Dr. Hidesaburo Hanafusa, The Rockefeller University, New York.  Sequence analysis of avian sarcoma viruses generated by recombination between transformation-defective mutants and normal cellular sequences.  Study of the relationship and origin of transforming genes of different strains of avian sarcoma viruses
1979-1985 Assistant Professor, The Rockefeller University, New York.  Sequences and functions of retroviral and cellular oncogenes; mechanism of recombination between viral and cellular sequences; viral RNA transcription and processing
1985-1988 Associate Professor (with tenure), Department of Microbiology, Mount Sinai School of Medicine, NYC, Expression and function of viral and cellular oncogenes; Transforming and tumorigenic potential of growth factor receptor genes; Mechanism of cell transformation, cancer development and progression. Signal transduction of protein tyrosine kinases and their messengers. Molecular basis of cancer cell survival, invasion and drug resistance. Development of targeted cancer therapy
1992- present Professor (with tenure), Department of Microbiology, Mount Sinai School of Medicine
1999-2004 Professor, Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine
2004- present Professor, Department of Oncological Science, Mount Sinai School of Medicine
2008- present Distinguished Investigator and Director, Division of Molecular and Genomic Medicine, National Health Research Institute, Taiwan
2009 April-July Acing Director, Immunology Center, NHRI
2008 - Adjunct professor, National Central University, Taiwan
2010 - Joint professor, Chinese Medical University, Taiwan
2012- Chair Professor, Chinese Medical University, Taiwan
2012- Chair Professor, Chiao Tung University, Taiwan
2011- Joint Professor National Tsin Hua University, Taiwan
2011- Adjunct professor National Taiwan University
2011 Sept-2012 Aug. Acting vice president, National Health Research Institute
2012 Sept-Dec Acting President, National Health Research Institute
2012 Dec- 2014 July Vice President, National Health Research Institute



Year Honors
1969 Coupon Award from National Taiwan University for Outstanding  Undergraduate Achievement
1977 Damon Runyon-Walter Winchell Cancer Fund Postdoc. Fellowship
1979 Scholar of American Leukemia Society (declined)
1979 American Cancer Society Junior Faculty Award (declined)
1979-1984 Research Career Development Award (NIH)
1996-1997 President, Tri-state Chapter, Society of Chinese Bioscientists in America
1998 Honorary Professor, Peking Union Medical College, China
2010 Academician, Academia Sinica, Taiwan
2010-2014 President, Chinese Asso of Cell and Molecular Society
2012 Fellow, TWAS (The World Academy of Science)
2013 Outstanding Breast Cancer Research Award, Breast Cancer Foundation, Taiwan



  • American Society of Virology
  • American Society of Microbiology
  • AAAS
  • New York Academy of Sciences
  • Society of Chinese Biochemists in America (Life Member)
  • SCBA Bio/Pharm Division Member
  • Chinese  Society of Cell and Molecular Biology, member and board
  • member,  2009-, President 2011-


Committees and Professional Activity

N.I.H. Ad Hoc Study Section and Site Visits:

  • Oct. 1984; Mar. 1985; May 1986; June 1989; Jan. 1995; Apr. 1995
  • January 2002, August, 2002, March, 2004

American Cancer Society: Study Section Meetings

Year Awards And Honors
1986-1990 NIH Experimental Virology Study Section.
1989 Symposium organizer, “Retroviruses, Oncogenes and Growth Factors”
Rockefeller University, November 30, 1989
1990- NIH Study Section Reviewers Reserve.
1986-1990 Editorial Board, Oncogene Research.
1993-1996 NIH Experimental Virology Study Section
1997 Symposium Chairperson, “Discovery of oncogenes: from crossroads to the future”, May 7, 1997, Rockefeller University.
1997-2010 Editorial Board, Virology
1997 Symposium organizer, Annual meeting, Tri-State Chapter, SCBA
1997-2001 Advisor Committee, DMGM, NHRI, Taiwan
2000- Consultant, National Health Research Institute (NHRI), Taiwan
2000-2002 Consultant, National Science Program in Pharmaceuticals and Biotechnology, Taiwan
2001 National Science Foundation, Ad Hoc Grant Review
2001 Co-organizer for the 17th International Oncogene Meeting
2002 Wellcom Foundation, Ad Hoc Grant Review
2002 Symposium Speaker, Endo 2002, the 84th Annual Meeting of the Endocrinology Society June 19-22, 2002
2002 Science Foundation Ireland, Ad Hoc Grant Review
2003-2005 Chief Editor, Biotech and Pharma.Quarterly, SCBA
2004 Project Reviewer, U.S.-Israel Binational Science Foundation
2004-2007 Consultant, Natl Research Program for Genomic Medicine, Taiwan
2009Feb Plenary speaker, 7th Chinese Society of Cell and Molecular Biology Symp
2009- Board member, Chinese Society of Cell and Molecular Biology
2009 Program director, 2009 IFCB Intl Training Program in Cell & Molecular Biology, June 15th to 26th, NHRI, Taiwan
2011- Associate Editor, J. Biomedical Science



Wang, L.-H. and Duesberg, P. (1973).  DNA polymerase of murine sarcoma-leukemia virus: Lack of detectable RNase H and low activity with viral RNA and natural DNA templates.  J.Virol.  12:1512-1521.
Wang, L.-H., and Duesberg, P. (1974).  Properties and location of poly(A) in Rous sarcoma virus RNA.  J.Virol. 14:1515-1529.
Duesberg, P.H., Kawai, S., Wang, L.-H., Vogt, P.K.,  Murphy, H.M., and Hanafusa, H. (1975).  RNA of replication-defective strains of Rous sarcoma virus.  Proc.Natl.Acad.Sci. USA 72:1569-1573.
Wang, L.-H., Duesberg, P., Beemon, K., and Vogt, P.K. (1975).  Mapping RNase T1-resistant oligonucleotides of avian tumor virus RNAs: Sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defection viruses are at the poly(A) end.  J.Virol. 16:1051-1070.
Wang, L.-H., Duesberg, P.H., Kawai, S., and Hanafusa, H. (1975).  Location of envelope-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus: In Comparative Leukemia Research 1975, Bibliotheca Haematologica, No. 43.  Eds. Clemmensen, J., and Yohn, D.S.  Karger, Basel, 1976, pp.542-548.
Duesberg, P.H., Wang, L.-H., Beemon, K., Kawai, S., and Hanafusa, H. (1975). Sequences and functions of Rous sarcoma virus RNA.  In Modern Trends in Human Leukemia II.  Eds. Neth, R., Mannweiler, K., and Gallo, R.C.  Grune and Stratton, New York, pp. 327-339.
Wang, L.-H., Duesberg, P.H., Kawai, S., and Hanafusa, H. (1976).  Location of envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus.  Proc.Natl.Acad.Sci. USA 73:447-451.
Wang, L.-H., Duesberg, P., Mellon, P., and Vogt, P. (1976).  Distribution of envelope-specific and sarcoma-specific nucleotide sequences from different parents in the RNAs of avian tumor virus recombinants.  Proc.Natl.Acad.Sci. USA 73:1073-1077.
Duesberg, P.H., Wang, L.-H., Mellon, P., Mason, W.S., and Vogt, P.K. (1976).  Towards a complete genetic map of Rous sarcoma virus.  In Proceedings of the ICN-UCLA Symposium (1976) on Animal Virology.  Eds. Baltimore, D., Huang, A., and Fox, C.F.  Academic Press, New York,  pp. 107-125.
Wang, L.-H., Galehouse, D., Mellon, P., Duesberg, P., Mason, W.S., Vogt, P.K. (1977).  Mapping oligonucleotides of Rous sarcoma virus RNA that segregate with polymerase and group-specific antigen markers in recombinants.  Proc.Natl.Acad.Sci. USA 73:3952-3956.
Duesberg, P.H., Wang, L.-H., Mellon, P., Mason, W.S., Vogt, P.K. (1977).  The genetic map of Rous sarcoma virus.  In Genetic Manipulation as it Affects the Cancer Problem.  Eds. Schultz, F., and Brada, Z.  Academic Press, New York, pp. 161-179.
Wang, L.-H., Duesberg, P.H., Robins, T., Yokota, H., Vogt, P.K. (1977).  The terminal oligonucleotides of avian tumor virus RNAs are genetically linked.  Virology 82:472-492.
Wang, L.-H., Levinson, W. (1978).  N-methyl Isatin B-thiosemicarbazon-copper complex inhibits RNA-dependent DNA polymerase but not ribonuclease H of Rous sarcoma virus.  Bioinorganic Chemistry 8:535-540.
Wang, L.-H., Halpern, C.C., Nadel, M., Hanafusa, H. (1978).  Recombination between viral and cellular sequence to generate transforming sarcoma virus.  Proc.Natl.Acad.Sci. USA 75:5812-5816.
Wang, L.-H. (1978). The gene order of avian RNA tumor viruses derived from biochemical analyses of deletion mutants and viral recombinants.  Ann.Rev.Microbiology 32:561-592.
Wang, L.-H., Karess, R., Moscovici, C., Hanafusa, H. (1979).  Analysis of src gene of recombinant viruses between transformation-defective mutant of Rous sarcoma virus and normal quail cells.  J. Virol. 32:546-556.
Wang, L.-H., Snyder, P., Hanafusa, T., Moscovici, C., and Hanafusa, H. (1980).  Comparative analysis of cellular and viral sequences related to sarcomagenic cell transformation.  Cold Spring Harbor Symp. Quant. Biology 44:755-764.
Hanafusa, T., Wang, L.-H., Anderson, S.M., Karess, R.E., Hayward, W.S., and Hanafusa, H. (1980).  Characterization of a new transforming gene of Fujinami sarcoma virus.  Proc.Natl.Acad.Sci. USA 77:3009-3013.                              
Wang, L.-H., Snyder, P., Hanafusa, T., Hanafusa, H. (1980).  Evidence for the common origin of viral and cellular sequences involved in sarcomagenic transformation.  J.Virol. 35:52-64.
Hanafusa, H., Wang, L.-H., Hanafusa, T., Anderson, S.M., Karess, R.E., and Hayward, W.S. (1980).  The nature and origin of the transforming gene of avian sarcoma viruses.  In Animal Virus Genetics,  Eds. Fields, B.N., Jaenish, R., and Fox, C.F.  Academic Press, New York,  Vol. 18, pp. 483-497.
Wang, L.-H., Feldman, R., Shibuya, M., Hanafusa, H., Notter, M.F.D., and Balduzzi, P.C. (1981).  Genetic structure, transforming sequence and gene product of avian sarcoma virus UR1.  J.Virol. 40:258-267.
Wang, L.-H., and Stacey, D. (1982).  Participation of subgenomic messenger RNAs in recombination.  J.Virol. 41:919-930.
Wang, L.-H., Hanafusa, H., Notter, M.F.D., and Balduzzi, P.C. (1982).  Genetic structure and transforming sequence of avian sarcoma virus UR2.  J.Virol. 41:833-841.
Feldman, R.A., Wang, L.-H., Hanafusa, H., and Balduzzi, P.C. (1982).  Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity.  J.Virol. 42:228-236.
Neel, B.G., Wang, L.-H., Mathey-Prevot, B., Hanafusa, T., Hanafusa, H., and Hayward, W.S. (1982).  Isolation of 16L virus: A rapidly transforming sarcoma virus from an avian leukosis virus-induced sarcoma.  Proc.Natl.Acad.Sci. USA 79:5088-5092.
Shibuya, M., Wang, L.-H., and Hanafusa, H. (1982).  Molecular cloning of Fujinami sarcoma virus genome and its comparison with sequences of other related transforming viruses.  J.Virol. 42:1007-1016.
Wang, L.-H., Beckson, M., Anderson, S., and Hanafusa, H. (1984).  Identification of the viral sequence required for the generation of recovered avian sarcoma viruses (rASVs) and characterization of a series of replication-defective rASVs.  J.Virol. 49:881-891.
Wang, L.-H., Edelstein, B., and Mayer, B.J. (1984).  Induction of tumors and generation of recovered sarcoma viruses (rASVs) by, and mapping of deletions in, two molecularly cloned src deletion mutants.  J.Virol. 50:904-913.
Neckameyer, W.S., and Wang, L.-H. (1984).  Molecular cloning of avian sarcoma virus (ASV) UR2 and comparison of its transforming sequence with those of other ASVs.  J.Virol. 50:914-921.
Neckameyer, W.S., and Wang, L.-H. (1985).  Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of tyrosine protein kinase oncogene family.  J.Virol. 53:879-884.
Parvin, J.D., and Wang, L.-H. (1984).  Mechanism for the generation of src-deletion mutants and recovered sarcoma viruses: Identification of viral sequences involved in src deletions and in recombination with c-src sequence.  Virology 138:236-245.
Wang, L.-H.  (1985). Deletion in the 3' pol sequence correlates with aberration of RNA expression in certain replication-defective avian sarcoma viruses.  J.Virol. 54:446-459.
Dutta, A., Wang, L.-H., Hanafusa, T., and Hanafusa, H. (1985). Partial nucleotidesequence of Rous  sarcoma virus-29 provides evidence that the original Rous sarcoma virus was replication- defective.  J.Virol. 55:728-735.
Neckameyer, W.S., Shibuya, M., Hsu, M.-T., and Wang, L.-H. (1986).  Proto-oncogene c-ros codes for a molecule with structural features common to those of growth factor receptors and displays tissue-specific and developmentally regulated expression.  Mol.Cell.Biol. 6:1478-1486.
Soong, M.-M., Iijima, S., and Wang, L.-H. (1986)  Mechanism of c-src transduction by a src deletion mutant of Rous sarcoma virus. J.Virol. 59:556-563.
Matsushime, H., Wang, L.-H., and Shibuya, M. (1986).  Human c-ros-1 gene homologous to v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptor-like molecule.  Mol.Cell.Biol. 6:3000-3004.
Wang, L.-H. (1988).  The ros oncogene. In Oncogene Handbook.  E.R. Reddy, T. Curran, A. Skalka (eds.)  The ros oncogene, Chap. 9, p135-148.
Wang, L.-H. (1987).  The mechanism of c-src transduction by avian retroviruses.  Mutation Research  186:135-147.
Wang, L.-H. and H. Hanafusa. (1988)  The avian sarcoma viruses.  Avian sarcoma viruses.  Virus Research 9:159-203.
Ellis, L., Morgan, D.O., Jong, S.-M., Wang, L.-H., Roth, R.A., and Rutter, W.J. (1987).  Heterologous transmembrane signaling by a human insulin receptor/v-ros hybrid in CHO cells.  Proc.Natl.Acad.Sci. USA 84:5101-5105.
Ellis, L., Morgan, D.O., Clauser, E., Reddy, M., Jong, S.-M., Wang, L.-H., Roth, R., and Rutter, W.J. (1986).  Mechanism of receptor-mediated transmembrane communication.  In Molecular Biology of Homo sapiens, Cold Spring Harbor Symposium Quantitative Biology, Vol. 51, Cold Spring Harbor Laboratory, pp 773-784.
Jong, S.-M., and Wang, L.-H. (1987).  The transforming protein P68gag-ros of avian sarcoma virus UR2 is a transmembrane protein with the p19 portion protruding extracellularly.  Oncogene Research, 1:7-21.
Wang, L.-H., Iijima, I., Dorai, T., and Lin, B. (1987).  Regulation of the expression of proto-oncogene c-src by alternative RNA splicing in chicken skeletal muscle.  Oncogene Research, 1:43-59.
Wang, L.-H., Lin, B., Jong, S.-M., Dixon, D., Ellis, L., Rutter, W.J. and Roth, R.  (1987).  Activation of the transforming potential of human insulin receptor gene.  Proc.Natl.Acad.Sci. USA 84:5725-5729.
Shibuya, M., Matsushime, H., Yamazaki, H., Wang, L.-H., Fukui, Y., Ueyama, Y.,. and Tamaoki, N. (1987)  Analysis of structure and activation of some receptor-type tyrosine kinase oncogenes.  In Oncogenes and Cancer, S.A. Aaronson et al. (eds.).  Japan Sci. Sco. Press, Tokyo, pp 195-202.
Levy, J.B., Dorai, T., Wang, L.-H., and Brugge, J.S. (1987).  The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.  Mol.Cell.Biol. 7:4142-4145.
Sudol, M., Kieswetter, C., Zhao, Yu-Hang, Dorai, T., Wang, L.-H., and Hanafusa, H. (1988).  Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison with the viral yes gene.  Nucleic Acids Res.  16:9876.
Rutter, W.J., Morgan, D., Ebina, Y., Wang, L.-H., Roth, R., and Ellis, L. (1988).  Membrane linked insulin receptor tyrosine kinase stimulates the insulin specific response.  Proc.Intl.Conf. on Insulin Action and Diabetes.  Calgary, March 26-27, 1987. H.J. Goren, (eds.)  Raven Press
Fukui, Y., Kornbluth, S., Jong, S.-M., Wang, L.-H., and Hanafusa, H. (1989)  Phosphotidylinositol kinase type I like activity associated with various oncogene products.  Oncogene Research 4:283-292.
Dorai, T., and Wang, L.-H. (1990)  An alternative non-tyrosine protein kinase product of the c-src gene in chicken skeletal muscle.  Mol. & Cell. Biol. 10:4068-4079.
Boulton, T.G., Gregory, J.S., Jong, S.-M., Wang, L.-H., Ellis, L., and Cobb, M.H. (1990)  Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.  J.Biol.Chem. 265:2713-2719.
Jong, S.-M.J., and Wang, L.-H. (1990)  The role of gag sequence in the biochemical properties and transforming activity of the avian sarcoma virus UR2-encoded gag-ros fusion protein.  J.Virol. 64:5997-6009.
Jong, S.-M.J., and Wang, L.-H. (1991)  Two point mutations in the transmembrane domain of P68gag-ros inactive its transforming activity and cause a delay in membrane association.  J.Virol. 65:180-189.
Chen, J., Heller, D., Poon, B., Kang, L. and Wang, L.-H. (1991)  Proto-oncogene c-ros codes for a transmembrane tyrosine protein kinase sharing sequence and structural homology with sevenless protein of Drosophila melanogaster.  Oncogene  6:257-264.
Poon, B., Dixon, D., Ellis, L., Roth, R.A., Rutter, W.J., and Wang, L.-H. (1991)  Molecular basis for activation of tumorigenic potential of a gag-human insulin receptor fusion gene.  Proc.Natl.Acad.Sci. USA 88:877-881.
Dorai, T., Levy, J.B., Kang, L., Brugge, J.S., and Wang, L.-H. (1991)  Analysis of cDNAs of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the genesis of the 3' end of v-src.  Mol.Cell.Biol.  August Issue, 11:4165-4176.
Liu,D., Chen, E., Poon, B., Rutter, W.J., and Wang, L.-H. (1992)  Enhancement of Transforming potential of human insulin-like growth factor I receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence.  J.Virology 66:374-385.
Jong, S.-M. J., Dorai, T., Wang, L.-H. (1992) Transforming properties and substrates specificities of the protein tyrosine kinase oncogenes ros, src and their recombinants. J. Virol. 66:4909-4918.
Liu, D., Rutter, W. J. and Wang, L.-H. (1992) Modulatory effect of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential. (1992) J. Virol. 67:9-18.
Liu, D., Zong, C. S. and Wang, L.-H. (1993) Distinctive effect of the carboxylterminal sequence of the insulinlike growth factor I on its signalling functions. J. Virol. 67:6835-6840.
Zong, C. S., Poon, B., Chen, J. and Wang, L.-H. (1993) Molecular and biochemical  basis for activation of the transforming potential of the proto-oncogene c-ros. J. Virol. 67:6453-6462.
Chen, J., Hanafusa, T. and Wang, L.-H. (1994) Alanine to glycine mutation in the     putative catalytic loop confers temperature sensitivity on ros, insulin receptor and insulinlike growth factor I receptor protein tyrosine kinases. Proc. Natl. Acad. Sci. U. S. A. 91:321-325.
Chen, J. Zong, C. S. and Wang, L.-H. (1994) Tissue and epithelial cell-specific expression of chicken proto-oncogene c-ros in several organs suggests that it may play roles in their development and mature functions. Oncogene 9: 773-780.
Liu, D. and Wang, L.-H. (1994) Oncogene, protein tyrosine kinases and signal  transduction. J. of Biomedical Sci. 1: 65-82.
Zong, C. S. and Wang, L-H. (1994)  Modulatory effect of the transmembrane domain of oncogene ros protein kinase on its biological function and substrate interaction. Proc.  Natl.  Acad.  Sci. U.S.A. 91:10982-10986.
Wang, L.-H. (1995) c-Ros protein tyrosine kinase. In The Protein Tyrosine Kinase  Factsbook.  Ed. D. G. Hardie.  pp 202-204.  Academic Press.
Chen, J., Tong, J., Tanaka-Sukegawa,I., and Wang,L.-H. (1995) Cloning and functional   characterization of the chicken c-ros promoter. Cell Growth& Differentiation 6: 1523-       1530.
Jiang,Y., Chan,J.-K., Zong, C.S. and Wang, L.-H. (1996) Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factorI receptor J. Biol. Chem. 271:160-167.
Xiong, Q., Chan, J. L.-K., Zong, C. S. & Wang, L.-H. (1996) Two chimeric receptors of epidermal growth factor receptor and c-Ros that differ in their transmembrane domains have opposite effects on cell growth. Mol.  & Cell. Biol.  16: 1509-1518.
Xiong, Q., Guo, Xiaojun, Zong, C. S., Jong, S.-M. J., Jiang, Y., Chan, J. and Wang, L.-H. (1996) Cloning and expression of chicken protein tyrosine phosphatase gamma. Biomedical J. 3:266-274.
Zong, C. S., Chan, J. L,-K., Yang, S.-K. and Wang, L.-H.(1997) Mutation of Ros  differentially effecting signal transduction pathways leading to cell growth and transformation.  J.  Biol.  Chem.  272:1500-1506.
Chan J. L.-K., Lai. M. and Wang. L.-H.(1997) Effect of dimerization on signal transduction and biological function of oncogenic Ros, insulin and insulin-like growth factor I receptors.  J.  Biol.  Chem.  272:146-153.
Chen. J., Sadowski, H., Kohanski, R. and Wang, L.-H.(1997) Stat5 is a physiological  substrate of the  insulin receptor.Proc.  Natl.  Acad.  Sci.  U.S.A. 94:2295-2300.
Li, W., Jiang, Y.-X., Zhang, J., Kapoor, V. Pierce, J. H. and Wang, L.-H. (1998) Protein kinase C delta is an important molecule in insulin-like growth factor I receptor-mediated cell transformation but not mitogenicity. Mol. Cell Biol. 18:5888-5898.
Zong, C. S., Zeng, L., Sadowski, H. and Wang, L.-H. (1998) Stat3 plays an important role in oncogenic Ros and insulin growth factor I receptor-mediated cell transformation.  J. Biol. Chem.273:28065-28072.
Soon, L., Flechner, L., Gutkind, J. S., Wang, L.-H., Baserga, R., Pierce, J.H. and Li, W. (1999)  Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression. Mol. Cell Biol. 19:3816-3828.
Zong, C. S., Chan, J., Levy, D. E., Horvath, C., Sadowski, H. B. and Wang, L.-H. 2000).  Mechanism of Stat3 activation by insulin-like growth factor I receptor. J. Biol. Chem. 275:15099-15105.
eng, L., Sachdev, P.,  Yan, L. Trenkel, T. and Wang. L.-H.  (2000) Vav3 mediates ignaling of receptor tyrosine kinases, modulates cell morphology and has cell ransforming potential. Mol. Cell. Biol. 20:9212-9224.
Nguyen, T. K. and Wang. L.-H. (2000) Differential requirement of the MAP kinase and PI3 kinase pathways for transformation of epithelial cells by src versus oncogenic insulin and IGF-1 receptors. Oncogene 19:5385-5397.
Hermanto, U., Zong, C. S. and Wang, L.-H. (2000) Inhibition of MEK selectively inhibits cell proliferation in human breast cancer cells displaying enhanced IGF-1-mediated MAP kinase activation. Cell Growth & Diff. 11:655-664.
Sachdev, P., Jiang, Y, Li, W., Miki, T., Maruta, H., Nur-E-Kamal, M.S.A. and Wang, L.-H. (2001)  Differential requirement for Rho family GTPases in oncogenic IGF-1 receptor-induced cell transformation. J Biol. Chem. 276:26461-26471.
Sadowski, C. L., Wheeler, T. T., Wang, L.-H. and Sadowski, H.B. (2001) Direct regulation of IGF-1 and SOCS-2 gene expression by growth hormone in C2C12 skeletal muscle cells. Endocrinology 142:3890-3900.
Sadowski, C. L., Choi, T.-S., Le, M., Wheeler, T. T., Wang, L.-H. and Sadowski, H. B. (2001) Insulin induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 skeletal muscle cells is mediated by Stat5. J. Biol. Chem. 276:20703-20710.
Sun, A. S., Yeh, H-C., Wang, L.-H., Huang, Y. P., Maeda, H. Pivazyan, A., Hsu, C., Lewis, E. R., Bruckner, H. W. and Fasy, T. M. (2001) Pilot study of a specific dietary supplement in tumor bearing mice and in stage IIIB and IV Non-small cell lung carcinoma  patients.  Nutrition and Cancer 39:85-95.
Hermanto, U., Zong, C. S. and Wang, L.-H.(2001)  ErbB2 overexpressing  human  mammary cancer cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in  anchorage independent growth. Oncogene 20:7551-7562.
Hermanto, U., Zong, C.S. and Wang, L.-H. (2002)  RACK1, an insulin-like growth factor I receptor-interacting protein, regulates IGF-I-dependent focal adhesion signaling, cell proliferation and colony formation. Mol. Cell. Biol. 22: 2345-2365.
Nguyen, T., Zong, C.S., Uttamsingh, S., Sachdev, P., Bhanot, M., Le, M., Chan, J. L.-K. and Wang, L.-H. (2002).The role of phosphatidylinositol 3-kinase, Rho family GTPases and Stat3 in ros-induced  cell transformation. J. Biol. Chem. 277:11107-11115.
Sachdev, P., Zeng, L. and Wang, L.-H. (2002). Distinct role pf phosphotidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes. J. Biol. Chem. 277:17638-17648.
Le, Maithao N., Kohanski, Ronald.A., Wang, Lu-Hai and Sadowski, Henry (2002). Dual mechanism of signal transduccer and activator of transcription 5 (Stat5) activation by the insulin receptor.  Molecular Endocrinology 16:2764-2779.
Uttamsingh, Shailaja, Zong, Cong S. and Wang, Lu-Hai (2003). Matrix-independent activation of PI3 kinase, Stat3 and cyclin A-associated Cdk2 is essential for anchorage independent growth of v-Ros transformed chicken embryo fibroblasts. J. Biol. Chem. 278:18798-18810.
Wang, Lu-Hai (2004) Molecular signaling regulating anchorage-independent growth of cancer cells. The Mount Sinai J. of Medicine 71:361-367.
Lopewz-Bergami, P., Hasen H., Bhoumik, A, Zhang, W., Wang L.-H., and Ronai, Z. (2005) Receptor for RACK1 mediates activation of JNK by protein kinase C. Mol. Cell 19:309-320.
Zhang, W., Zong, C. S., Hermanto, U., Lopez-Bergami, P., Ronai, Z. and Wang, L.-H. (2005) RACK1 recruits STAT3 specifically to insulin and IGF-1 receptors for activation, which is important for regulating anchorage independent growth. Mol. Cell Biol. 26:413-424.
Yio, X., Diamond, M., Zhang, J.-Y., Weinstein, H., Wang, L.-H., Werther, L. and Itzkowitz, S. (2006) Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways. Gastroenterology  130:1696-706.
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K Masker, A. Golden, C. J. Gaffney, V. Mazack, W. F. Schwindinger, W. Zhang, L.-H. Wang, D.J. Carey and M. Sudol (2007). Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral src. Virology 364:10-20.
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Uttamsingh, S, Bao, X., Nguyen, K. T., Bhanot M., Chan J. L.-K., Liu F, Chu T. and  Wang, L-H. (2008) Synergistic effect between EGF and TGF-1 in inducing oncogenic properties of intestinal epithelial cells.  Oncogene 27:2626-2634.
Cheng G Z, Zhang W, Sun M, Wang, Q, Coppola D, Costanzo C, Xu L M, Chan J, Cheng J Q, Wang L-H. (2008) Twist is Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function. J. Biol. Chem. 283:14665-73.
Cheng G. Z., Park S., Shu S., He L., Kong W., Zhang W., Yuan Z., Wang L.-H., Cheng   J. Q. (2008) Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery. Current Cancer Drug Targets 8:2-6.
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 Shih Sheng Jiang, Wen-Tsen Fang, Ya-Shi Ho, Shiu-Feng Huang, Betty Lin-Ju Yen, Junn-Liang Chang, Shi-Miao Li, Hui-Ping Liu, Ying-Lan Liu, Chi-Ting Huang, Yu-Wei Li, Te-Hsuan Jan, Su-Jing Yang, Chao A. Hsiung, Cheng-Wen Wu, Lu-Hai Wang, and I-Shou Chang (2010) Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity Clinical Cancer Research, 16: 4363-4373.
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Lin, K.T. , Gong, J, Jang, T. H., Chen, H. J., Li, J. F. and Wang, L-H. (2012) Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence. Cancer Research 72 (12):3000-3009.
1 Lin, K.-Y, Wang, L-H., Hsen, Y. -C., Fung, C. -L., Yang, H. -L., Senthil Kumar, K.J., Tai,    C. and Uen, Y.-H. (2012) Clinical significance of increased guanine nucleotide exchange  factor Vav3 expression in human gastric cancer. Molecular Cancer Research 10(6):  750-759.
Shih HJ, Chen HH, Chen YA, Wu MH, Liou GG, Chang WW, Chen L, Wang LH, Hsu HL.(2012) Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity. Oncotarget. 3(11):1401-15.
Shih HJ, Chu KL, Wu MH, Wu PH, Chang WW, Chu JS, Wang LH, Takeuchi H, Ouchi T, Hsu HL.(2012) The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities. Cell Cycle. 11(5):934-52.
Yu-Ming Yeh, Chi-Mu Chuang, Kuan-Chong Chao and Lu-Hai Wang (2013)  MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1a. Intl J. Cancer 133(4):867-78
Wei-Chieh Huang, Shih-Hsuan Chan, Te-Hsuan Jang, Jer-Wei Chang, Ying-Chin Ko, Tzu-Chen Yen, Wei-Fan Chiang, Tien-Yu Shieh, Shang-Lun Chiang, Chun-Ta Liao, Jyh-Lyh Juang, Ann-Joy Cheng, Hsueh-Chun Wang, Ya-Ching Lu, and Lu-Hai Wang (2014) Identification of miRNA-491-5p and GIT1 as the modulators and biomarkers for oralsquamous cell carcinoma (OSCC) invasion and metastasis. Cancer Research  74:751-764.
Shih-Hsuan Chan, Wei-Chieh Huang, Jer-Wei Chang, King Jang Chang, Wen-Hung Kuo, Ming-Yang Wang, Kai-Yuan Lin, Yih-Huei Uen, Ming-Feng Hou, Chao-Mei Lin, Meng-Chong Tan, Te-Hsuan Jang and Lu-Hai Wang. (2014)  MicroRNA-149 targets GIT1 to suppress breast cancer metastasis. Oncogene 33(36):4496-507
Fang, Wen-Tsen; Fan, Chi-Chen; Li, Shih-Miao; Jang, Te-Hsuan; Lin, Hsiu-Ping; Shih, Neng-Yao; Chen, Chung-Hsing; Wang, Tao-Yeuen; Huang, Shiu-Feng; Lee, Alan Yueh-Luen; Liu, Ying-Lan; Tsai, Fang-Yu; Huang, Chih-Ting; Yang, Su Jing; Yen, Lin-Ju; Chuu, Chih-Pin; Chen, Chih-Yi; Hsiung, Chao A.; Chang, Jang-Yang; Wang, Lu-Hai; Chang, I-Shou; Jiang, Shih Sheng. (2014) "Downregulation of a Putative Tumor Suppressor BMP4 by SOX2 Promotes Growth of Lung Squamous Cell Carcinoma" Intl J Cancer 135(4):809-19.
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Kai-Ti Lin, Yu-Ming Yeh, Scarlett Y. Yang, Jer-Wei Chang, Shu-Pin Sun, Chi-Mu  Chuang, Kuan-Chong Chao, and Lu-Hai Wang. (2015) Glucocorticoids Mediate Induction of  MicroRNA-708 to Suppress Ovarian Cancer Cell Invasion and Metastasis through Targeting Rap1B. Nature Comm Jan 8;6:5917. doi: 10.1038/ncomms6917
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 Hui-Ming Chen, Ge Ma, Neil Gildener-Leapman, Samuel Eisenstein, Brian A. Coakley, Junko Ozao, John Mandeli, Celia Divino, Myron Schwartz, Max Sung, Robert Ferris, Johnny Kao, Lu-Hai Wang, Ping-Ying Pan, Eric C. Ko, and Shu-Hsia Chen (2015) Myeloid-Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent  Sunitinib and Stereotactic Body Radiotherapy.  Clin Cancer Res; 21(18) 4073-4085.
Kai-Ti Lin and Lu-Hai Wang  (2016) New Dimension of Glucocorticoids in Cancer  Treatment. Steroids. 111:84-88.
Jer-Wei Chang, Shih-Hsuan Chan, King Jang Chang, Chiao-Mei Lin, Chi-Chen Chang, Wen-Hung Kuo, Ming-Yang Wang, and Lu-Hai Wang.  Wild type, but not mutant, p53 transcriptionally activates an early onset breast cancer-associated gene to suppress metastasis. (in preparation)
Jer-Wei Chang, Shih-Hsuan Chan, Chiao-Mei Lin, Chi-Chen Chang, Meng-Fan Chiu King Jang Chang, Wen-Hung Kuo, Ming-Yang Wang, Kai-Yuan Lin, Yih-Huei Uen, Ming-Feng Hou and Lu-Hai Wang.  A regulatory role of ubiquitin ligase FBXL7 and its intronic microRNA-887 in breast cancer metastasis. (in preparation)
Tung, Shiao-Lin, Yang, Zhi-Ping, Huang, Wei-Chieh and Wang, Lu-Hai.  MicroRNA-34c-5p inhibits ovarian cancer stemness via down regulation of  amphiregulin-Raf-ERK pathway. (in preparation)
Wu, Jun-I., Lin, Yi-Pei, and Wang, Lu-Hai. Stress-induced Crabp2 is overexpressed in early colonized lung cancer cells to facilitate anchorage-independent growth and  angiogenesis. (in preparation)
Lin, Kai-Ti, Huang, Jo-ting , Chen, Wen-Ling and Wang, Lu-Hai. Cystathionine  gamma-lyase (CSE) affects PKM2 tetramerization via H2S to regulate glycolysis and prostate cancer cell invasion and metastasis. (in preparation)
Huang, Wei-Chieh, Jang, Te-Hsuan, Chan, Shih-Hsuan and Wang, Lu-Hai. Keratin 16 stabilizes c-Met to promote oral squamous cell carcinoma (OSCC)  metastasis (in preparation)