Member » President

PRESIDENT MIEN-CHIE HUNG

Contact

 

Current Position

  • President, China Medical University (Taiwan) , 2019
  • Academician, Academia Sinica (Taiwan)

 

Education

  • National Taiwan University, Taipei, BS, 1973, Chemistry
  • National Taiwan University, Taipei, MS, 1977, Biochemistry
  • Brandeis University, Waltham, MA, PHD, 1983, Biochemistry (Mentor: Pieter C. Winsink, Ph.D.)

 

Professional Experiences

Professional Experiences
  • Professor, The University of Texas M.D. Anderson Cancer Center, TX, 09/94-02/17/19    
  • Department Chair, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2000−02/17/19
  • Director, Center for Biological Pathways, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008−02/17/19
  • Vice President for Basic Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2010−02/17/19
  • Ruth Legett Jones Distinguished Chair, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2003−02/17/19 Ruth Legett Jones

 

Awards and Honors

Awards and Honors
  • John P. McGovern Outstanding Teacher Award University of Texas Health Science Center-Houston (1990, 1993, 1999, 2018), the only faculty receives this award four times.
  • Faculty Achievement Award in Education (1993) and in Basic Research (1998, 2017), The University of Texas M. D. Anderson Cancer Center.
  • Member, Pathology B Study Section (1996 – 2000) and Sub-committee C (2001-2005), NIH.
  • Founding Editorial Board, Cancer Cell 2001-present
  • Editor-in-Chief, American Journal For Cancer Research 2015-2017
  • Reappointed with the Highest Commendation by the Membership Committee, GSBS, 2005 & 2016 (five-year period)
  • Senior Editor, Cancer Research, American Association for Cancer Research (2018-2021)
  • Academician of the Academia Sinica, Taiwan (2002)
  • Member, The University of Texas Academy of Health Science Education.(2006)
  • Distinguished Teaching Professor, The University of Texas M. D. Anderson Cancer Center.(2007)
  • Full Member, Scientific Advisory Council, Susan G Komen.(2010-2016)
  • Fellow, section of Biological Sciences, American Association for the Advancement of Science.(2010)
  • Honorary President (life time), Breast Cancer Society of Taiwan(2010)
  • Presidential Award, Society of Chinese Bioscientists in America(2011)
  • The University of Texas M. D. Anderson Cancer Center LeMaistre Outstanding Achievement Award.(2011)
  • Outstanding Alumni Award, National Taiwan University, Taipei, Taiwan(2014)
  • Simiao Sun Award for Biomedical Achievement, Dalian Medical University Cancer Center, China
  • Co-Chair, 2017 AACR Annual Meeting Program Committee(2015-2017)
  • Lifetime Achievement Award, Society of Chinese Bioscientists in America(2017)
  • Regents’ Outstanding Teaching Award, The University of Texas System
  • Inaugural awardee of Breast Cancer Basic and Translational Research Outstanding Achievement Award, International Breast Cancer Stem Cell Symposium, Zhanjiang, Guangdong(2017)
  • Honorary Dean, West China School of Basic Medical Sciences & Forensic Medicine of Sichuan University, Chengdu, China(2018-2021)
  • President-elect, The University of Texas Academy of Health Science Education.(2018-2019)
  • Honorary Principal Academic Advisor, Taiwan Breast Cancer Society, 2020.
  • 2021 Highly Cited (HiCi) Researchers (Clarivate).
  • Member, Emeritus Investigator, Breast Cancer Research Foundation 2022
  • Ranked No. 1 cited scientist in the category of Genetics and Molecular Biology, Rank No. 2 in the Medicine category in Taiwan. (Research.com, 2022)
  • Rank No. 2 in Taiwan of 2022 Ranking of the Best Scientist in The World, Research.com (based on H-index data from Microsoft Academic Graph). There are only three scientists are in the list of “the Best Scientists in the world” from Taiwan.
  • Fellow, The World Academy of Sciences for the advancement of science in developing countries. Jan 1, 2023.
  • International Award, the Japanese Cancer Association (JCA), 2023
  • Special Achievement Award, Taiwan Society of Thoracic Surgeons, 2023

 

Publications [Google Scholar]

ORCID: 0000-0003-4317-4740.
lifetime h-index (Scopus) is 148 (Google Scholar: 170).
179 out of 642 peer-reviewed publications are published in journals which impact factor is 10 or above, of which 73 (51 CNS--Cell, Nature, Science series) serves as a corresponding (first or co-corresponding) author and 106 (69 CNS) as a co-author. 120 out of 179 are published in Cell, Nature, Science series.

SELECTED PUBLICATIONS
  • Xing, X., Wang, S-C., , Xia, W.Y.,  Zou, Y., Shao, R., Kwong, K.Y., Yu, Z., Zhang, S., Miller, S., Huang, L., and Hung, M.-C.  The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesisNature Medicine6:189-195, 2000.
  • Lin, S.-Y., Xia, W., Wang, J. C., Kwong, K-Y., Spohn, B., Wen, Y., Pestell, R.G. and Hung, M.-C.  b-catenin, a novel prognostic marker for breast cancer:  its roles in cyclin D1 expression and cancer progression. Proc. Natl. Acad. Sci. 97:4262-4266, 2000. 
  • Zhou, B.P., Liao, Y., Xia, W., Spohn, B., Lee, M.H., and Hung, M.-C.  Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nature Cell Biology 3(3):245-252, 2001.
  • Lin, S.Y., Makino, K., Xia, W., Matin, A., Wen, Y., Kwong, K.Y., Bourguignon, L., and Hung, M.-C.  Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nature Cell Biology 3:803-808, 2001.
  • Zhou, B.P., Liao, Y., Xia, W., Zou, Y., Spohn, B., and Hung, M.-C.  HER-2/neu induces ubiquitination via Akt-mediated MDM2 phosphorylation. Nature Cell Biology 3:973-982, 2001.
  • Hortobagyi, G.N., Ueno, N.T., Xia, W., Zhang, S., Wolf, J.W., Putnam, J.B., Weiden, P.L., Willey, J.S., Carey, M., Warner, D.L., Payne, J.Y., Tucker, S.D., Bartholomeusz, C., Kilbourn, R.G., De Jager, R.L., Sneige, N., Katz, R.L., Daifuku, R., Ibrahim, N.K., Murray, J.L., Theriault, R.L., Valero, V., Gershenson, D.M., Bevers, M.W., Huang, L., Lopez-Berestein, G. and Hung, M.-C.  Cationic liposome-mediated adenovirus type 5 E1A gene transfer to human breast and ovarian cancer cells and its biological effects: A phase I clinical trial. J. Clin. Oncol. 19:3422-3433, 2001.
  • Deng, J., Miller, S. A., Wang, H.-Y., Xia, W., Wen, Y., Zhou, B., Lin, S.-Y., Li, Yan and Hung, M.-C.  b-Catenin interacts with and inhibits NF-kB in human colon and breast cancers. Cancer Cell 2: 323-334,2002.
  • Tan, M., Jing, T., Lan, K.-H., Neal, C.L., Li, P., Lee, S., Fang, E., Nagata, Y., Liu, J., Arlinghaus, R., Hung, M.-C. and Yu, D.  Phosphorylation on tyrosine-15 of p34cdc2 by ErbB2 inhibits p34Cdc2 activation and is involved in resistance to Taxol-induced apoptosis. Molecular Cell 9: 993-1004, 2002*. * Selected as a cover on May issue.
  • Asada, S., Choi, Y., Yamada, M., Wang, S.-C., Hung, M.-C., Qin, J. and Uesugi, M.  External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc. Natl. Acad. SciUSA 99:12747-12752, 2002.
  • Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X.-M., Lardy, H., Huang, K.-E., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., Xing, L., Boyce, B.F., Hung, M-C., Zhang, S. and Chang, C.  Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc. Natl. Acad. Sci. USA 99: 13498-13503, 2002.
  • Feng, Z., Hu, W., Chen, J. X., Pao, A., Li, H., Rom, W. N., Hung, M.-C., Adair, G.M. and Tang, M.-S.  Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J. Natl. Cancer Inst. 94:1527-1536, 2002*. *Accompanied by Editorial “Etiology of the mutational spectrum of ras gene in human carcinomas” by Kelley, M. J. and Littman, S. J. J. Natl. Cancer Inst. 94:1516-1517, 2002. Accompanied by BBC news embargo “Carcinogen in cigarettes causes mutation linked to lung cancer” on October 14, 2002.
  • Hu, M.C-T, Lee, D.-F., Xia, W., Golfman, L., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S, Hanada, N., Saso, H., Kobayashi R. and Hung, MC.  IkB kinase promotes tumourigenesis through inhibition of Forkhead transcription factor FOXO3a. Cell 117:225-237, 2004.
  • Wang, S-C., Lien, H-C., Xia, W., Chen, I-F., Lo, H-W., Wang, Z., Ali-Seyed, M., Bartholomeusz, G., Ou-Yang, F., Giri, D.K. and Hung, MC.  Binding at and transactivation of COX-2 promoter by nuclear tyrosine kinase receptor ErbB2. Cancer Cell 6:251-261, 2004.
  • Zhou, B.P., Deng, J., Xia, W., Xu, J., Li, Y.M., Gundaz, M. and Hung, MC.  Dual regulation of Snail by GSK-3b-mediated phosphorylation in control of epithelial-mesenchymal transition. Nature Cell Biology6:931-940, 2004.
  • Nagata, Y., Lan, K-H., Zhou, X., Tan, M., Esteva, F.J., Sahin, A.A., Klos, K.S., Li, P., Monia, B.P., Nguyen, N.T., Hortobagyi, G.N., Hung, MC and Yu, D.  PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6:117-127, 2004*. *Accompanied by many news release—Nature online news: www.nature.com/news; CNN news on Aug. 23, 2004; NBC Universal news on Aug. 23, 2004; MD Anderson Special News Release, Aug. 23, 2004; National Post of Canada, Aug. 24, 2004; Cancer Biology and Therapy, Aug. 24, 2004; The World Journal-- New York, Aug. 24, 2004; BCN (BreastCancer.Net) News, Aug. 24, 2004; www.reutershealth.com. ; Medical Post- Toronto; Shingtao Daily (a Chinese news paper); and Houston Chronicle.
  • Li, Y.M., Pan, Y., Wei, Y., Cheng, X., Zhou, B., Tan, M., Zhou, X., Xia, W., Hortobagyi, G.N., Yu, D. and Hung, MC  Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell6:459-469, 2004.
  • Lo, H-W., Hsu, S-C., Ali-Seyed, M., Gunduz, M., Xia, W., Wei, Y., Bartholomeusz, G., Shih, J-Y.,and Hung, M-C.  Nuclear interaction of EGFR and STAT3 in the activation of iNOS/NO pathway. Cancer Cell 7:575-589, 2005.
  • Ding, Q., Xia W., Liu, J-C., Yang, J-Y., Lee, D-F., Xia, J., Bartholomeusz, Li, Y., Pan, Y., Li, Z., Bargou, RC., Qin, J., Lai, C-C., Tsai, F-J. Tsai, C-H. and Hung, M-C.  Erk1/2 associates with and primes GSK-3b for its inactivation resulting in upregulation of b-catenin. Molecular Cell 19:159-170, 2005.
  • Cha, T-L., Zhou, BP., Xia, W., Wu, Y., Yang, C-C., Chen, C-T., Ping, B. Otte, A.P. and Hung, M-C.  Akt-mediated phosphorylation of EZH2 augments methylation of lysine 27 in histone H3. Science 310:306-310, 2005.
  • Wang, S-C., Nakajima, Y., Yu, Y-L., Li, L-Y., Chen, C-T, Hawke, D., Kobayashi, R. and Hung, M-C.  Tyrosine phosphorylation controls protein stability of PCNA. Nature Cell Biology. 8:1359-1368, 2006.
  • Su, J-L., Yang, P-C., Shih, J-Y., Yang, C-Y., Wei, L-H., Hsieh, C-Y., Chou, C-H., Jeng, Y-M., Wang, M-Y., Chang, K-J., Hung, M-C. and Kuo, M-L.  The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 9:209-223, 2006.
  • Huang, W-C., Ju, T-K., *Hung, M-C. and *Chen, C-C. Phosphorylation of CBP by IKKa promotes cell growth by switching the binding preference of CBP from p53 to NF-kB. Molecular Cell26:75-87, 2007. *co-corresponding author.
  • Xie, X., Xia, W., Li, Z., Kuo, H-P.,Liu, Y., Li, Z., Ding, Q., Zhang, S., Spohn, W., Yang, Y., Wei, Y., Lang, J-Y., Evans, D.B., Chiao, P.J., Abbruzzese J.L. and Hung, M-C. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell, 12:52-65, 2007.
  • Lee, D-F., Kuo, H-P., Chen, C-T., Hsu, J-M., Sun, H-L., Chou, C-K., Wei, Y., Li, L-Y.,Ping, B., Huang, W-C., He, X., Hung, J-Y., Lai, C-C., Ding, Q., Su, J-L., Yang, J-Y., Sahin, A.A., Hortobagyi, G.N., Tsai, F-J., Tsai, C-H. and Hung, M-C. Suppression of TSC1 by IKKb confers tumor angiogenesis through the mTOR pathway. Cell130:440-455, 2007.
  • Wang, R-H., Zheng, Y., Kim, H-S., Xu, X., Cao, L., Luhasen, T., Lee, M-H., Xiao, C., Vassilopoulos, A., Chen, W., Gardner, K., Man, Y-G., Hung, M-C., Finkel, T. and Deng, C-X. Interplay among BRAC1, SIRT1 and Survivin during BRAC1-associated tumorigenesis. Molecular Cell, 32:11-20, 2008*. *Previews: “SIRTing through breast cancer is just a survivin’ game” by Jianyuan Luo and Dario C. Altieri, Molecular Cell 32:159-160, 2008.
  • Kang, T., Wei, Y., Honaker, Y., Yamaguchi, H., Appella, E., Hung, M-C. and Piwnica-Worms, H.  GSK-3β targets Cdc25A for ubiquitin-mediated proteolysis and GSK-3β inactivation leads to Cdc25A overproduction in human cancers. Cancer Cell 13: 36-47, 2008.
  • Yang, J-Y., Zong, C.S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J-Y., Lai, C-C., Chang, C-J., Huang, W-C., Huang, H., Kuo, H-P., Lee, D-F., Li, L-Y., Lien H-C., Cheng, X, Chang, K-J., Hsiao, C-D., Tsai, F-J., Tsai, C-H., Sahin, AA., Muller, WJ., Mills, GB., Yu, D., Hortobagyi, GN. and Hung, M-C. Erk promotes tumorigenesis by inhibiting Foxo3a via MDM2-mediated degradation. Nature Cell Biology10:138-148, 2008.
  • Zhang, W., Tsan, R., Wu, Q., Huang, W-C., Chiu, C-H., *Fidler, I.J. and *Hung, M-C. Survival of cancer cells is maintained by kinase-independent EGFR. Cancer Cell 13:383-393, 2008. *Co-Corresponding authors.
  • Lee, D-F., Kuo, H-P., Liu, M., Chou, C-K., Xia, W., Du, Y., Shen, J., Shen, J., Chen, C-T., Huo, L., Hsu, M-C., Li, C-W., Ding, Q., Liao, T-L., Lai, C-C., Lin, A-C. Chang, Y-H, Tsai, S-F., Li, L-Y. and Hung, M-C. KEAP1 E3 ligase-mediated down regulation of NF-kB signaling by targeting IKKb. Molecular Cell 36: 131-140, 2009.
  • Liu, S., Umezu-Goto, M., Murph, M., Lu, Y., Liu, W., Zhang, F., Yu, S., Stephens, L.C., Cui, Z., Murrow, G., Coombes, K., Muller, W., Hung, M-C., Perou, C. M., Lee, A. V., Fang, X. and Mills, G. B. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion and metastasis. Cancer Cell 15:539-550, 2009.
  • Lu, J, Guo, H, Treekitkarnmongkol, W, Li, P, Zhang, J, Shi, B, Ling C, Zhou, X, Chen, T, Chiao, P, Feng X, Seewaldt, V, Muller, W, Sahin, A, Hung, M-C and Yu, D. 14-3-3ζ cooperates with ErbB2 to promote progression of ductal carcinoma in situ to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell 16:195-207, 2009.
  • Hildebrandt, MAT., Yang, H., Hung, M-C., Izzo, JG., Huang, M., Lin, J., Ajani, JA and Wu, X. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. Journal of Clinical Oncology27:857-871 (Epub Jan 21), 2009.
  • Jiralerspong, S., Palla, S., Girodano, S., Meric-Bernstam, F., Liedtke, C., Barnett, C., Hsu, L. Hung, M-C., Hortobagyi, G and Gonzalez-Angulo, A.M. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. Journal of Clinical Oncology (Epub June 1), 27: 3297-3302, 2009.
  • Lu C., Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MMK, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung M-C, Lopez-Berestien G, Sood AK. Regulation of tumor angiogenesis by EZH2. Cancer Cell 18 (2): 185-197, 2010.
  • Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT, Mills GB, Hortobagyi GN, Mendelsohn J, Hung MC, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated activation of Src and inactivation of PTEN. Cancer Cell 18:423-435, 2010.
  • Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung M-C, Pandolfi PP and Lin HK. Deciphering the transcription complex critical for RhoA gene expression and cancer metastasis. Nature Cell Biology, 12(5): 457-467 (Epub online April 11), 2010.
  • Huo LF, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding QQ, Chen CH, Tsai CH, Hung M-C. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc. Natl. Acad. Sci.  107(37):16125-16130 (Epub online August 27), 2010.
  • Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cell. Nature Cell Biology13 (1):87-94(Epub online December 5, 2010), 2011.
  • Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a noncanonical histone signature to breast cancer. Nature Dec 16; 468(7326):927-932, 2010.
  • Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast cancer tumor initiating cells through activation of RAF-b-catenin signaling.  Cancer Cell 19 (1):86-100, (Epub online Jan 5), 2011.
  • Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between R1175 methylation and Y1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nature Cell Biology13(2):174-181, (Epub online Jan 23), 2011.
  • Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu J, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition (EMT) and stem cell properties through modulation of miRNAs. Nature Cell BiologyMar;13(3):317-323 (Epub online Feb 20), 2011.
  • Tsai KS, Yang SH, Lei YP, Tsai CC, Chen HW, Hsu CY, Chen LL, Wang HW, Miller SA, Chiou SH, *Hung MC and *Hung SC. Mesenchymal stem cells within tumors enhance xenograft tumor formation in colorectal cancer.  GastroenterologySep;141(3):1046-1056 (Epub online May 31), 2011. *Co-corresponding authors
  • Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC Jr. Dasatinib-enhanced paclitaxel cytotoxicity by upregulation of p27Kip1 and downregulation of Bcl-2 and CDK1. JNCI Sep 21;103(18):1403-1422 (Epub online August 2), 2011.
  • Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell Sep 13;20(3):341-356, 2011.
  • Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai CC, Li HB, Yen CJ, Kuo HP, Lee DF, Lang JY, Huo LF, Cheng XY, Chen YJ, Li CW, Jeng LB, Hsu J, Li LY, Tan A, Curley SA, Ellis LM, DuBois RN and Hung MC. Genes that mediate colorectal cancer metastasis to liverJournal of Clinical Investigation Nov 1;121(11):4526-4536 (Epub online Oct 10), 2011.
  • Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC.  IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Molecular Cell 45(2):171-184 (Epub on line Dec 20, 2011), 2012.
  • Wang Y, Ding QQ, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Miller SA, Wang X, Lee DF, Hsu JL, Hsu JM, Huo LF, LaBaff AM, Liu DP, Huang TH, Lai CC, Tsai FJ, Chang WC, Chen CH, Wu TT, Buttar NS, Wang KK, Wu Y, Wang H, Ajani J, Hung MC. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell 21, 374–387 (DOI 10.1016/j.ccr.2011.12.028), 2012.
  • Ling J, Kang Y, Lee D-F, Xia Q, Zhao R, Chang Z, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/b/NF-kB activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell Jan 17, 21:105-120, 2012.
  • Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH. Rac1 activation mediates Twist1-induced cancer cell migration. Nature Cell Biology 14:366-374, (Epub March 11, doi: 10.1038/ncb2455), 2012. PMID: 22407364.
  • Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KC, Flores LG, Shao Y, Hazel JDYu D, Wei W, Sarbassov D, Hung MC, Nakayama K, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis. Cell 149:1098-1111, 2012.
  • Lee DF, Su J, Ang YS Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJK, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moor KA, Snoeck HW, Ma’ayan A, Schaniel C, Lemischka IR. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell Aug 3, 11(2):179-194, 2012.
  • Chen D, Su Y, Wei Y, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nature Medicine 18(10):1511-1517, (EPub online Sept 23), 2012.
  • Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O’Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 de-stabilization. Genes and Development 27(3):274-287, 2013.
  • Dong C, Yuan T, Wu Y, Wang Y, Fan TWM, Miriyala S, Lin Y, Yao J, Shi J, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of RBP1 by snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell (Epub online Feb 7, doi:pii: S1535-6108(13)00042-1. 10.1016/j.ccr.2013.01.022), 2013.
  • Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim SO, Du Y, Wang Y, Chang WC, Chen CH, Hsu JL, Wu Y, Lam YC, James BP, Liu X, Liu CG, Patel DJ, Hung MC.  EGFR modulates miRNA maturation in response to hypoxia through phosphorylation of Ago 2. Nature May 16; 497(7449):383-387 (epub online May 1, doi: 10.1038/nature12080.), 2013.
  • News in Cancer Discovery “EGFR Regulates microRNA Processing via Modification of AGO2”, May 9, 2013 (DOI: 10.1158/2159-8290.CD-RW2013-099);
  • “MICRORNA Lacking in Maturity” Nicola McCarthy, Nature Reviews Cancer (published online 16 May 2013; doi:10.1038/nrc3534)
  • Editor’s Choice “Hypoxia Prevents miRNA Processing” Nancy R. Gough, Science Signaling 21 May, 2013 Vol 6, Issue 276, p. ec111 (doi: 10.1126/scisignal.2004336)
  • Chan CH, Morrow JK, Li CF, GaoY, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis C, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cells and cancer progression. Cell 154:556-568, 2013.
  • Wagner K, Alam H, Dhar S, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani A, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach J, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling in NSCLC. Journal of Clinical Investigation 123 (12): 5231-5246, (pii: 68642. doi: 10.1172/JCI68642. Epub online Nov 8), 2013.
  • Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitination and stabilization of PTEN by USP13. Nature Cell Biology Dec; 15(12):1486-1494 (doi:10.1038/ncb2874, Epub Nov 24), 2013.
  • Huang TH, Huo LF, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, Shen J, Lee HH, Lee PC, Wu Y, Chen CH, Hung MC. EGFR potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell 23(6):796-810, 2013.
  • Chiou GY, Chien CS, Wang ML, Chen MT, Yang YP, Yu YL, Chien Y, Chang YC, Shen CC, Chio CC, Lu KH, Ma HI, Chen KH, Liu DM, Miller SA, Chen YW, Huang PI, Shin YH, *Hung MC, *Chiou SH. Epigenetic regulation of the MiR142-3p/Interleukin-6 circuit in glioblastoma.  Molecular Cell Dec 12; 52(5):693-706, (doi:10.10.16/j.molcel,2013.11.009), 2013. *Co-corresponding authors
  • Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Kuo SC, Chen CH, Yu YL*, Hung MC*. EGFR modulates DNA synthesis and repairs through Tyr phosphorylation of Histone H4. Development Cell 30(2):224-237, (doi: 10.1016/j.devcel.2014.06.008), 2014. *co-corresponding authors.
  • Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Medema RH, Hung MC, Huang S. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-b-dependent cancer metastasis. J Clin Invest. 124(2):564-579 (pii:71104, doi:10.1172/JCI71104, Epub Online Jan 2), 2014.
  • Zhang K, Chou CK, Xia X, Hung MC, Qin L. Block-cell-printing for live single-cell printing. Proc. Natl. Acad. Sci. 111(8): 2948-2953, (doi: 10.1073/pnas.1313661111, Epub online Feb 10),2014.
  • Yan M, Zhang Y, He B, Zheng FM, Xiang J, Xu, J, Chen MY, Zhu YL, Wen HJ, Wan XB, Yue CF, Yang N, Zhang W, Zhang JL, Wang J, Wang ZF, Zeng YX, Lam EWF, Hung MC, Liu Q. IKKa restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation. Nature Communication April 17; 4:3661 (doi:10.1038/ncomms4661), 2014.
  • Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache V, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.  Molecular Cell 54(6):960-974 (epub online May 22, doi:10.1016/j.molcel.2014.04.024), 2014.
  • Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. Journal of Clinical Investigation124(7):3093-3106, 2014.
  • Zhang P, Wei Y, Wang L, Debeb B, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward W, Liu Y, Dean D, Liang H, Hu Y, Ang K, Hung MC, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nature Cell Biology (Aug 3, doi: 10.1038/ncb3013, epub online), 2014.
  • Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, Hung MC, Lin C, Yang L. LncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell 159(5):1110-1125 (Epub online Nov 13), 2014.
  • Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK, Lin SY and Hng MC. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Research 25(2):225-236 (Epub online Jan 20; doi:10.1038/cr.2015.8), 2015.
  • Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XHF, Hung MC, Zhang JD, Yu D. 14-3-3z turns TGF-b’s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell 27(2):177-192, 2015.
  • Lee DF, Su J, Kim HS, Chang B, Papatsenko D, Zhao R, Yuan Y, Gingold J, Xia W, Darr H, Mirzayans R, Hung MC, Schaniel C, Lemischka IR.Modeling familial cancer with induced pluripotent stem cells. Cell 161(2):240-254, 2015.
  • Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E, Wu SY, Ivan C, Moss TJ, Ram PT, Wang H, Gol-Chambers A, Ozkayar O, Kanlikilicer P, Fuentes-Mattei E, Kahraman N, Pradeep S, Ozpolat B, Tucker S, Hung MC, Baggerly K, Bartholomeusz G, Calin G, Sood AK, Lopez-Berestein G. The ZNF304-integrin axis protects against anoikis in cancer. Nature Communications 6:7351 (doi: 10.1038/ncomms8351), 2015. 
  • Perillo EP, Liu YL, Huynh K, Liu C, Chou CK, Hung MC, Yeh HC, Dunn AK. Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination. Nature Communications 6:7874 (doi: 10.1038/ncomms8874), 2015.
  • Hu D, Gur M, Zhou Z, Gamper A, Hung MC, Fujita N, Lan L, Bahar I, Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nature Communications September 30, 6:8419, 2015.
  • Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RS, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Armaiz-Peña GM, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung MC, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK. Erythropoietin stimulates tumor growth via EphB4. Cancer Cell 28:610-622 (pii: S1535-6108(15)00339-6. doi: 10.1016/j.ccell.2015.09.008. Oct 14, Epub online), 2015.
  • Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC.  Methylation of EGFR by PRMT1 regulates EGFR signaling and cetuximab response. Journal of Clinical Investigation 125: 4529-4543, (Nov 16 epub online), 2015.
  • Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard P, Lee GR IV, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Blocking c-Met-mediated PAPR1 phosphorylation enhances PARP inhibitor response.  Nature Medicine 22(2):194-201 (Epub online Jan 18), 2016.
  • Lin A, Lin C, Xin Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park, PK, Zhou J, Zhou Y, Hu Z, Zou Y, Mark JR, Liang H, Hung MC, Lin C, Yang L. The Link-A ncRNA activates normoxic HIFa signaling in triple-negative breast cancer. Nature Cell Biology 18(2): 213-224, (Epub online Jan 11), 2016.
  • Zheng F, Yue C, Li G, He B, Cheng W, Wang X, Yan M, Long Z, Qiu W, Yuan Z, Xu J, Shi Q, Lam EWF, Hung MC, Liu Q. Nuclear AURKA acquires kinase independent transactivating function to enhance breast cancer stem cell phenotype. Nature Communications Jan 19; 7:10180 (doi: 10.108/ncomms10180), 2016.
  • Wu SY, Rupaimoole R, Shen F, Pradeep S, Pecot CV, Ivan C, Nagaraja AS, Gharpure KM, Pham E, Hatakeyama H, McGuire MH, Haemmerle M, Vidal-Anaya V, Olsen C, Rodriguez-Aguayo C, Filant J, Ehsanipour EA, Herbrich SM, Maiti SN, Huang L, Kim JH, Zhang X, Han HD, Armaiz-Pena GN, Seviour EG, Tucker S, Zhang M, Yang D, Cooper LJ, Ali-Fehmi R, Bar-Eli M, Lee JS, Ram PT, Baggerly KA, Lopez-Berestein G, Hung MC, Sood AK. A miR-192-EGR-HOX89 regulatory network controls the angiogenic switch in cancer. Nature Communications April 4: 7:11169 (doi:10.1038/ncomms11169), 2016.
  • Liu CC, Lin SP, Hsu HS, Yang SH, Lin CH, Yang MH, Hung MC, Hung SC. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumor initiation and metastasis in cancer stem cells. Nature Communications 7:11798, 2016.
  • Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC. Glycosylation and stabilization of programmed death ligand-1 suppresses T cell activity. Nature Communications 7:12632 (doi: 10.1038/ncomms12632, Epub online Aug 30), 2016.
  • Sun HL, Cui R, Zhou J, Teng KY, Hsiao UH, Nakanishi K, Fassan M, Luo Z, Shi G, Tili E, Kutay H, Lovat F, Vicentini C, Huang HL, Wang SW, Kim T, Zanesi N, Jeon YJ, Lee TJ, Guh JH, Hung MC, Ghoshai K, Teng CM, Peng Y, Croce CM. ERK activation globally downregulates miRNAs through phosphorylation Exportin-5.  Cancer Cell 30(5):723-736 (epub online Nov 14), 2016. 
  • Lim SO, Li CW, Xia X, Cha JH, Chan LC, Wu Y, Chang SS, Lin WC, Hsu JM, Hsu YH, Kim T, Chang WC, Hsu JL, Yamaguchi H, Ding Q, Wang Y, Yang Y, Chen CH, Sahin AA, Yu D, Hortobagyi GN, Hung MC. Deubiquitination and stabilization of PD-L1 by CSN5. Cancer Cell30(6):925-939 (epub online Nov 14), 2016.
  • Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, Lin HK. A hypoxia-response TRAF6-ATM-H2AX signaling axis promotes HIF1a activation, tumorigenesis and metastasis. Nature Cell Biology 19(1): 38-51 (Epub online Dec 5, 2016), 2017.
  • Zhao X, Guo Y, Jiang C, Chang Q, Zhang S, Luo T, Zhang B, Jia X, Hung MC, Dong C, Lin X. JNK1 negatively controls anti-fungal innate immunity by suppressing CD23 expression. Nature Medicine 23(3):337-346, (Epub online Jan 23), 2017.
  • Li C, Wang S, Xing Z, Lin A, Liang K, Song J, Hu Q, Yao J, Chen Z, Park P, Hawke DH, Zhou J, Zhou Y, Zhang S, Liang H, Hung MC, Gallick G, Han L, Lin C, Yang L. A ROR1-HER3-Lnc RNA signaling axis modulates the Hippo-Yap pathway to regulate bone metastasis. Nature Cell Biology 19(2):106-119 (Epub Jan 23), 2017.
  • Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SG, Park MK, Hwang JP, Billalabeitia EG, Hung MC, Song SJ, Song MS. A UBE2O-AMPKa axis that promotes tumor initiation and progression offers opportunities for therapy. Cancer Cell (Epub online Jan 31), 2017.
  • Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y, Yao J, Liang K, Wang S, Park PK, Marks JR, Zhou Y, Zhou J, Hung MC, Liang H, Hu Z, Shen H, Hawke DH, Han L, Zhou Y, Lin C, Yang L. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Nature Cell Biology Mar;19(3):238-251 (Epub Feb 20), 2017.
  • Ju HQ, Ying HY, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Hung MC, DePinho RA, Huang P, Xu RH, Chiao PJ. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in the development of pancreatic ductal adenocarcinoma. Nature Communications Feb 24;8:14437, 2017.
  • Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and functional impacts of ER coactivator sequential recruitment. Mol Cell, 67(5):733-743,  2017.
  • Nilsson MB, Sun H, Diao L, Tong P, Liu D, Li L, Fan Y, Poteete A, Lim SO, Howells K, Haddad V, Gomez D, Tran H, Pena GA, Sequist LV, Yang JC, Wang J, Kim ES, Herbst R, Lee JJ, Hong WK, Wistuba I, Hung MC, Sood AK, Heymach JV. Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers. Sci Transl Med. 9(415) pii: eaao4307, 2017.
  • Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. J Clin Invest 27(12):4498-4515 (Epub Nov 13), 2017.
  • Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Wei Y, Wang H, Hung MC, Hsieh SY. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis. Hepatology 67(6):2226-2243(Epub Nov 23, 2017), 2018.
  • Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF, Hung MC, Suzuki HI, Chen PS. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest 128(2):625-643, (Epub Dec18, 2017), 2018.
  • Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M, Hung MC*, Wei W*. Phosphorylation of EZH2 by AMPK suppresses PRC methyltransferase activity and oncogenic function. Mol Cell 69(2):279-291, 2018. *Co-corresponding authors.
  • Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, Khoo KH, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC. Eradication of triple-negative breast cancer cells by targeting glycosylated PD-L1. Cancer Cell 33(2):187-201, 2018.
  • Wang YN, Lee HH, Chou CK, Yang WH, Wei Y, Chen CT, Yao J, Hsu JL, Zhu C, Ying H, Ye Y, Wang WJ, Lim SO, Xia W, Ko HW, Liu X, Liu CG, Wu X, Wang H, Li D, Prakash LR, Katz MH, Kang Y, Kim M, Fleming JB, Fogelman D, Javle M, Maitra A, Hung MC. Angiogenin/ribonuclease 5 is an EGFR ligand and a serum biomarker for erlotinib sensitivity in pancreatic cancer. Cancer Cell 33(4): 752-769 (epub online March 29), 2018.
  • Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, Khoo KH, Hsu JL, Li CW, Lim SO, Chang SS, Chen YC, Ren GX, Hung MC. STT3-dependent PD-L1. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.  Nature Comm 9(1):1908, 2018.
  • Yang Y, Li CW, Chan LC, Wei Y, Hsu J, Xia W, Chan JH, Hou J, Hsu JL, Sun L, Hung MC. Exosomal PD-L1 harbors active defense function to suppress T cell killing and promote tumor growth of breast cancer cells.  Cell Res 28:862-864, (epub online June 29) 2018.
  • Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo KH, Hung MC. Metformin promotes antitumor immunity via endoplasmic reticulum-associated degradation of PD-L1. Mol Cell 71(4):606-620, 2018.
  • Wang T, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hou Y, Hung MC, Lin X. The adaptor protein CARD9 protects against colon cancer by restricting mycobiota-mediated expansion of myeloid-derived suppressor cells. Immunity 49(3):504-514, 2018.
  • Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia X, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, Huang WC, Chiang SF, Nie L, Hou J, Chen CT, Huo L, Yang WH, Deng R, Nakai K, Hsu YH, Chang SS, Chiu TJ, Tang J, Chang SJ, Zhang R, Wang L, Fang B, Chen T, Wong KK, Hsu JL, Hung MC. Targeting PKCδ as a therapeutic strategy against the heterogeneity of EGFR inhibitor resistance in EGFR-mutant lung cancer. Cancer Cell 34(6):954-969, 2018.
  • Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P. Sirohi K, Li X, We Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B. BAP1 links metabolic regulation of ferroptosis to tumor suppression. Nat Cell Biol 20 (10):1181-1192 (epub online Sept 18), 2018.
  • Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Long non-coding RNA MALAT1 suppresses breast cancer metastasis. Nature Genetics 50(12):1705-1715 (epub online Oct 22), 2018.
  • Yang Y, Hsu JM, Sun L, Li CW, Chan LC, Wei Y, Xia W, Hou J, Hsu JL, Hung MC. Palmitoylation stabilizes PD-L1 to promote breast tumor growth.  Cell Res (epub online Dec 4), 2018.
  • Ju HQ, Lu YX, Chen DL, Zuo ZX, Liu ZX, Wu QN, Mo HY, Wang ZX, Wang DS, Pu HY, Zeng ZL, Li B, Xie D, Huang P, Hung MC, Chiao PJ, Xu RH. Modulation of Redox homeostasis by inhibition of MTHFD2 in colorectal cancer: mechanisms and therapeutic implications. J Natl Cancer Inst (epub online Dec 8), 2018.
  • Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR, Putluri N, Hawke DH, Han L, Hung MC, Danesh FR, Yang LLin C, PTEN-induced Partial epithelial-mesenchymal transition drives diabetic kidney Disease. J Clin Invest (in press)
  • Park MK, Yao Y, Xia W, Setijono SR, Kim JH, Vila I, Chiu HH, Wu Y, Billalabeitia E, Lee MG, Kalb RG, Hung MC, Pandolfi PP, Song SJ, Song MS. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nature Comm (in press) 2019.
  • Li H, Li CW, Li X, Ding Q, Guo L, Liu C, Lai CC, Hsu JM, Dong Q, Xia W, Hsu JL, Yamaguchi H, Du Y, Lai YJ, Koller PB, Ye Q, Hung MC. c-MET inhibitors induce immune resistance through PD-L1 stabilization in hepatocellular carcinoma. Gastroenterology(in press) 2019.
  • Zhu Y, Yang J, Xu D, Gao XM, Zhang Z, Hsu JL, Li CW, Lim SO, Sheng YY, Zhang Y, Li JH, Luo Q, Zheng Y, Zhao Y, Lu L, Jia HL, *Hung MC, *Dong QZ, *Qin LX. Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut Sep;68(9):1653-1666 (Epub online March 22) 2019. *Co-corresponding Authors
  • Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Wang WH, Yen EY, Chang WC, Zha Z, Lim SO, Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y, Nie L, Hsu JL, Li H, Ye Q, Hassan MM, Amin HM, Kaseb AO, Lin X, Wang SC, Hung MC. IL-6/JAK1 drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. J Clin Invest July 15;29(8):3324-3338, 2019.
  • Lee HH, *Wang YN, Xia W, Chen CH, Rau KM, Ye L, Chou CK, Wei Y, Wang SC, Yan M, Tu CY, Hsia TC, Chiang SF, Chao KSC, Wistuba II, Hsu JL, Hortobagyi GN, Hung MC. Removal of N-linked glycosylation enhances PD-L1 detection and predicts anti-PD-1/PD-L1 therapeutic efficacy. * Equal contribution. Cancer Cell Aug 12;36(2):168-178, (Epub July 18) 2019.
  • *Nie L, *Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davison NE, Hortobagyi GN, Hung MC. CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. *Equal contribution. Nature Communications 10(1):5114, 2019.
  • #*Xu D, #Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, *Hung MC, *Lu Z. The gluconeogenic enzyme PCK1phosphorylates INSIG1/2 for lipogenesis. Nature 580(7804):530-535 (Epub April 8), 2020.
  • Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JH, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC. PD-L1-mediated Gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumor necrosis. Nature Cell Biology, Oct;22(10):1264-1275 (Sept 14 Epub online) 2020. https://doi.org/10.1038/s41556-020-0575-z. PMC7653546. Comments: “Cell Death: PD-L1 controls cancer pyroptosis” by Blasco MT, Gomis RR. Nature Cell Biol Oct 22:1155-1161, 2020
  • Liu CX†, Zha Z†, Zhou C†, Chen Y, Xia W, Wang YN, Lee HH, Yin Y, Yan M. Chang CW, Qiu Y, Li H, Li CW, Hsu JM, Hsu JL, Wang SC, Ren N*, Hung MC*. Ribonuclease 7-driven activation of ROS1 is a new potential therapeutic target in hepatocellular carcinoma. J of Hepatology, 5(20):33674-33676, 2020.
  • *Yang R†, Sun L†, Li CF, Wang YH, Yao J, Li H, Yan M, Chang WC, Hsu JM, Cha JH, Hsu JL, Chou CW, Sun X, Deng Y, Chou CK, Yu D, *Hung MC. Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. †Equal contribution *co-corresponding authors. Nature CommFeb 5: 12:832, 2021
  • Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC. Tyro3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin InvestApr 15;131(8):139434, 2021.
  • Lee HH†, Wang YN†, Yang WH†, Xia W, Wie Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL, Yamaguchi, Pang D, Hortobagyi GN, Yu D, Hung MC. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nature Communications 12(1):2788, (May 13 epub online), 2021.
  • Deng Y, Xia Xi, Zhao Y, Zhao Z, Martinez C, Yin W, Yao J, Hang Q, Wu W, Zhang J, Yu Y, Xia W, Yao F, Zhao D, Sun Y, Ying H, Hung MC*, Li M*. Glucocorticoid receptor regulates PD-L1 and MHCI in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nat Comm 12:7041, 2021.