Member » President

PRESIDENT MIEN-CHIE HUNG

Contact

Office: No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung City 406, Taiwan
Tel: +886-4-22053366 ext.1000
Fax: +886-4-22952121
E-mail: mhung@mail.cmu.edu.tw
Secretary：Yu-Lin (Lynn) Hung & Chien-Chiao Hung (Research Affairs)

Current Position

President, China Medical University (Taiwan) , 2019
Academician, Academia Sinica (Taiwan)

Education

National Taiwan University, Taipei, BS, 1973, Chemistry
National Taiwan University, Taipei, MS, 1977, Biochemistry
Brandeis University, Waltham, MA, PHD, 1983, Biochemistry (Mentor: Pieter C. Winsink, Ph.D.)

Professional Experiences

Professional Experiences
Professor, The University of Texas M.D. Anderson Cancer Center, TX, 09/94-02/17/19 Department Chair, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2000−02/17/19 Director, Center for Biological Pathways, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008−02/17/19 Vice President for Basic Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2010−02/17/19 Ruth Legett Jones Distinguished Chair, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2003−02/17/19 Ruth Legett Jones

Professor, The University of Texas M.D. Anderson Cancer Center, TX, 09/94-02/17/19
Department Chair, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2000−02/17/19
Director, Center for Biological Pathways, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008−02/17/19
Vice President for Basic Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2010−02/17/19
Ruth Legett Jones Distinguished Chair, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2003−02/17/19 Ruth Legett Jones

Awards and Honors

Awards and Honors
John P. McGovern Outstanding Teacher Award University of Texas Health Science Center-Houston (1990, 1993, 1999, 2018), the only faculty receives this award four times. Faculty Achievement Award in Education (1993) and in Basic Research (1998, 2017), The University of Texas M. D. Anderson Cancer Center. Member, Pathology B Study Section (1996 – 2000) and Sub-committee C (2001-2005), NIH. Founding Editorial Board, Cancer Cell 2001-present Editor-in-Chief, American Journal For Cancer Research 2015-2017 Reappointed with the Highest Commendation by the Membership Committee, GSBS, 2005 & 2016 (five-year period) Senior Editor, Cancer Research, American Association for Cancer Research (2018-2021) Academician of the Academia Sinica, Taiwan (2002) Member, The University of Texas Academy of Health Science Education.(2006) Distinguished Teaching Professor, The University of Texas M. D. Anderson Cancer Center.(2007) Full Member, Scientific Advisory Council, Susan G Komen.(2010-2016) Fellow, section of Biological Sciences, American Association for the Advancement of Science.(2010) Honorary President (life time), Breast Cancer Society of Taiwan(2010) Presidential Award, Society of Chinese Bioscientists in America(2011) The University of Texas M. D. Anderson Cancer Center LeMaistre Outstanding Achievement Award.(2011) Outstanding Alumni Award, National Taiwan University, Taipei, Taiwan(2014) Simiao Sun Award for Biomedical Achievement, Dalian Medical University Cancer Center, China Co-Chair, 2017 AACR Annual Meeting Program Committee(2015-2017) Lifetime Achievement Award, Society of Chinese Bioscientists in America(2017) Regents’ Outstanding Teaching Award, The University of Texas System Inaugural awardee of Breast Cancer Basic and Translational Research Outstanding Achievement Award, International Breast Cancer Stem Cell Symposium, Zhanjiang, Guangdong(2017) Honorary Dean, West China School of Basic Medical Sciences & Forensic Medicine of Sichuan University, Chengdu, China(2018-2021) President-elect, The University of Texas Academy of Health Science Education.(2018-2019) Honorary Principal Academic Advisor, Taiwan Breast Cancer Society, 2020. 2021 Highly Cited (HiCi) Researchers (Clarivate). Member, Emeritus Investigator, Breast Cancer Research Foundation 2022 Ranked No. 1 cited scientist in the category of Genetics and Molecular Biology, Rank No. 2 in the Medicine category in Taiwan. (Research.com, 2022) Rank No. 2 in Taiwan of 2022 Ranking of the Best Scientist in The World, Research.com (based on H-index data from Microsoft Academic Graph). There are only three scientists are in the list of “the Best Scientists in the world” from Taiwan. Fellow, The World Academy of Sciences for the advancement of science in developing countries. Jan 1, 2023. International Award, the Japanese Cancer Association (JCA), 2023 Special Achievement Award, Taiwan Society of Thoracic Surgeons, 2023

John P. McGovern Outstanding Teacher Award University of Texas Health Science Center-Houston (1990, 1993, 1999, 2018), the only faculty receives this award four times.
Faculty Achievement Award in Education (1993) and in Basic Research (1998, 2017), The University of Texas M. D. Anderson Cancer Center.
Member, Pathology B Study Section (1996 – 2000) and Sub-committee C (2001-2005), NIH.
Founding Editorial Board, Cancer Cell 2001-present
Editor-in-Chief, American Journal For Cancer Research 2015-2017
Reappointed with the Highest Commendation by the Membership Committee, GSBS, 2005 & 2016 (five-year period)
Senior Editor, Cancer Research, American Association for Cancer Research (2018-2021)
Academician of the Academia Sinica, Taiwan (2002)
Member, The University of Texas Academy of Health Science Education.(2006)
Distinguished Teaching Professor, The University of Texas M. D. Anderson Cancer Center.(2007)
Full Member, Scientific Advisory Council, Susan G Komen.(2010-2016)
Fellow, section of Biological Sciences, American Association for the Advancement of Science.(2010)
Honorary President (life time), Breast Cancer Society of Taiwan(2010)
Presidential Award, Society of Chinese Bioscientists in America(2011)
The University of Texas M. D. Anderson Cancer Center LeMaistre Outstanding Achievement Award.(2011)
Outstanding Alumni Award, National Taiwan University, Taipei, Taiwan(2014)
Simiao Sun Award for Biomedical Achievement, Dalian Medical University Cancer Center, China
Co-Chair, 2017 AACR Annual Meeting Program Committee(2015-2017)
Lifetime Achievement Award, Society of Chinese Bioscientists in America(2017)
Regents’ Outstanding Teaching Award, The University of Texas System
Inaugural awardee of Breast Cancer Basic and Translational Research Outstanding Achievement Award, International Breast Cancer Stem Cell Symposium, Zhanjiang, Guangdong(2017)
Honorary Dean, West China School of Basic Medical Sciences & Forensic Medicine of Sichuan University, Chengdu, China(2018-2021)
President-elect, The University of Texas Academy of Health Science Education.(2018-2019)
Honorary Principal Academic Advisor, Taiwan Breast Cancer Society, 2020.
2021 Highly Cited (HiCi) Researchers (Clarivate).
Member, Emeritus Investigator, Breast Cancer Research Foundation 2022
Ranked No. 1 cited scientist in the category of Genetics and Molecular Biology, Rank No. 2 in the Medicine category in Taiwan. (Research.com, 2022)
Rank No. 2 in Taiwan of 2022 Ranking of the Best Scientist in The World, Research.com (based on H-index data from Microsoft Academic Graph). There are only three scientists are in the list of “the Best Scientists in the world” from Taiwan.
Fellow, The World Academy of Sciences for the advancement of science in developing countries. Jan 1, 2023.
International Award, the Japanese Cancer Association (JCA), 2023
Special Achievement Award, Taiwan Society of Thoracic Surgeons, 2023

Publications [Google Scholar]

ORCID: 0000-0003-4317-4740.
lifetime h-index (Scopus) is 148 (Google Scholar: 170).
179 out of 642 peer-reviewed publications are published in journals which impact factor is 10 or above, of which 73 (51 CNS--Cell, Nature, Science series) serves as a corresponding (first or co-corresponding) author and 106 (69 CNS) as a co-author. 120 out of 179 are published in Cell, Nature, Science series.

SELECTED PUBLICATIONS
Xing, X., Wang, S-C., , Xia, W.Y., Zou, Y., Shao, R., Kwong, K.Y., Yu, Z., Zhang, S., Miller, S., Huang, L., and Hung, M.-C. The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nature Medicine6:189-195, 2000. Lin, S.-Y., Xia, W., Wang, J. C., Kwong, K-Y., Spohn, B., Wen, Y., Pestell, R.G. and Hung, M.-C. b-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. *Proc. Natl. Acad. Sci. 97:4262-4266, 2000. Zhou, B.P., Liao, Y., Xia, W., Spohn, B., Lee, M.H., and Hung, M.-C.* Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. *Nature Cell Biology* 3(3):245-252, 2001. Lin, S.Y., Makino, K., Xia, W., Matin, A., Wen, Y., Kwong, K.Y., Bourguignon, L., and Hung, M.-C. Nuclear localization of EGF receptor and its potential new role as a transcription factor. *Nature Cell Biology* 3:803-808, 2001. Zhou, B.P., Liao, Y., Xia, W., Zou, Y., Spohn, B., and Hung, M.-C. HER-2/neu induces ubiquitination via Akt-mediated MDM2 phosphorylation. *Nature Cell Biology* 3:973-982, 2001. Hortobagyi, G.N., Ueno, N.T., Xia, W., Zhang, S., Wolf, J.W., Putnam, J.B., Weiden, P.L., Willey, J.S., Carey, M., Warner, D.L., Payne, J.Y., Tucker, S.D., Bartholomeusz, C., Kilbourn, R.G., De Jager, R.L., Sneige, N., Katz, R.L., Daifuku, R., Ibrahim, N.K., Murray, J.L., Theriault, R.L., Valero, V., Gershenson, D.M., Bevers, M.W., Huang, L., Lopez-Berestein, G. and Hung, M.-C. Cationic liposome-mediated adenovirus type 5 E1A gene transfer to human breast and ovarian cancer cells and its biological effects: A phase I clinical trial. *J. Clin. Oncol. 19:3422-3433, 2001. Deng, J., Miller, S. A., Wang, H.-Y., Xia, W., Wen, Y., Zhou, B., Lin, S.-Y., Li, Yan and Hung, M.-C.* b-Catenin interacts with and inhibits NF-kB in human colon and breast cancers. *Cancer Cell* 2: 323-334,2002. Tan, M., Jing, T., Lan, K.-H., Neal, C.L., Li, P., Lee, S., Fang, E., Nagata, Y., Liu, J., Arlinghaus, R., Hung, M.-C. and Yu, D. Phosphorylation on tyrosine-15 of p34cdc2 by ErbB2 inhibits p34Cdc2 activation and is involved in resistance to Taxol-induced apoptosis. *Molecular Cell* 9: 993-1004, 2002. Selected as a cover on May issue. Asada, S., Choi, Y., Yamada, M., Wang, S.-C., Hung, M.-C., Qin, J. and Uesugi, M. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. *Proc. Natl. Acad. Sci. USA* 99:12747-12752, 2002. Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X.-M., Lardy, H., Huang, K.-E., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., Xing, L., Boyce, B.F., Hung, M-C., Zhang, S. and Chang, C. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. *Proc. Natl. Acad. Sci*. USA 99: 13498-13503, 2002. Feng, Z., Hu, W., Chen, J. X., Pao, A., Li, H., Rom, W. N., Hung, M.-C., Adair, G.M. and Tang, M.-S. Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J. Natl. Cancer Inst. 94:1527-1536, 2002. Accompanied by Editorial “Etiology of the mutational spectrum of ras gene in human carcinomas” by Kelley, M. J. and Littman, S. J. *J. Natl. Cancer Inst. 94:1516-1517, 2002. Accompanied by BBC news embargo “Carcinogen in cigarettes causes mutation linked to lung cancer” on October 14, 2002. Hu, M.C-T, Lee, D.-F., Xia, W., Golfman, L., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S, Hanada, N., Saso, H., Kobayashi R. and Hung, MC.* IkB kinase promotes tumourigenesis through inhibition of Forkhead transcription factor FOXO3a. *Cell* 117:225-237, 2004. Wang, S-C., Lien, H-C., Xia, W., Chen, I-F., Lo, H-W., Wang, Z., Ali-Seyed, M., Bartholomeusz, G., Ou-Yang, F., Giri, D.K. and Hung, MC. Binding at and transactivation of COX-2 promoter by nuclear tyrosine kinase receptor ErbB2. *Cancer Cell* 6:251-261, 2004. Zhou, B.P., Deng, J., Xia, W., Xu, J., Li, Y.M., Gundaz, M. and Hung, MC. Dual regulation of Snail by GSK-3b-mediated phosphorylation in control of epithelial-mesenchymal transition. *Nature Cell Biology6:931-940, 2004. Nagata, Y., Lan, K-H., Zhou, X., Tan, M., Esteva, F.J., Sahin, A.A., Klos, K.S., Li, P., Monia, B.P., Nguyen, N.T., Hortobagyi, G.N., Hung, MC* and Yu, D. PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients. *Cancer Cell* 6:117-127, 2004. Accompanied by many news release—Nature online news: www.nature.com/news; CNN news on Aug. 23, 2004; NBC Universal news on Aug. 23, 2004; MD Anderson Special News Release, Aug. 23, 2004; National Post of Canada, Aug. 24, 2004; Cancer Biology and Therapy, Aug. 24, 2004; The World Journal-- New York, Aug. 24, 2004; BCN (BreastCancer.Net) News, Aug. 24, 2004; www.reutershealth.com. ; Medical Post- Toronto; Shingtao Daily (a Chinese news paper); and Houston Chronicle. Li, Y.M., Pan, Y., Wei, Y., Cheng, X., Zhou, B., Tan, M., Zhou, X., Xia, W., Hortobagyi, G.N., Yu, D. and Hung, MC Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. *Cancer Cell6:459-469, 2004. Lo, H-W., Hsu, S-C., Ali-Seyed, M., Gunduz, M., Xia, W., Wei, Y., Bartholomeusz, G., Shih, J-Y.,and Hung, M-C.* Nuclear interaction of EGFR and STAT3 in the activation of iNOS/NO pathway. *Cancer Cell* 7:575-589, 2005. Ding, Q., Xia W., Liu, J-C., Yang, J-Y., Lee, D-F., Xia, J., Bartholomeusz, Li, Y., Pan, Y., Li, Z., Bargou, RC., Qin, J., Lai, C-C., Tsai, F-J. Tsai, C-H. and Hung, M-C. Erk1/2 associates with and primes GSK-3b for its inactivation resulting in upregulation of b-catenin. *Molecular Cell* 19:159-170, 2005. Cha, T-L., Zhou, BP., Xia, W., Wu, Y., Yang, C-C., Chen, C-T., Ping, B. Otte, A.P. and Hung, M-C. Akt-mediated phosphorylation of EZH2 augments methylation of lysine 27 in histone H3. *Science* 310:306-310, 2005. Wang, S-C., Nakajima, Y., Yu, Y-L., Li, L-Y., Chen, C-T, Hawke, D., Kobayashi, R. and Hung, M-C. Tyrosine phosphorylation controls protein stability of PCNA. *Nature Cell Biology.* 8:1359-1368, 2006. Su, J-L., Yang, P-C., Shih, J-Y., Yang, C-Y., Wei, L-H., Hsieh, C-Y., Chou, C-H., Jeng, Y-M., Wang, M-Y., Chang, K-J., Hung, M-C. and Kuo, M-L. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. *Cancer Cell* 9:209-223, 2006. Huang, W-C., Ju, T-K., *Hung, M-C. and Chen, C-C. Phosphorylation of CBP by IKKa promotes cell growth by switching the binding preference of CBP from p53 to NF-kB. Molecular Cell26:75-87, 2007. co-corresponding author. Xie, X., Xia, W., Li, Z., Kuo, H-P.,Liu, Y., Li, Z., Ding, Q., Zhang, S., Spohn, W., Yang, Y., Wei, Y., Lang, J-Y., Evans, D.B., Chiao, P.J., Abbruzzese J.L. and Hung, M-C. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. *Cancer Cell, 12:52-65, 2007. Lee, D-F., Kuo, H-P., Chen, C-T., Hsu, J-M., Sun, H-L., Chou, C-K., Wei, Y., Li, L-Y.,Ping, B., Huang, W-C., He, X., Hung, J-Y., Lai, C-C., Ding, Q., Su, J-L., Yang, J-Y., Sahin, A.A., Hortobagyi, G.N., Tsai, F-J., Tsai, C-H. and Hung, M-C.* Suppression of TSC1 by IKKb confers tumor angiogenesis through the mTOR pathway. *Cell130:440-455, 2007. Wang, R-H., Zheng, Y., Kim, H-S., Xu, X., Cao, L., Luhasen, T., Lee, M-H., Xiao, C., Vassilopoulos, A., Chen, W., Gardner, K., Man, Y-G., Hung, M-C., Finkel, T. and Deng, C-X. Interplay among BRAC1, SIRT1 and Survivin during BRAC1-associated tumorigenesis. Molecular Cell, 32:11-20, 2008. Previews: “SIRTing through breast cancer is just a survivin’ game” by Jianyuan Luo and Dario C. Altieri, Molecular Cell* 32:159-160, 2008. Kang, T., Wei, Y., Honaker, Y., Yamaguchi, H., Appella, E., Hung, M-C. and Piwnica-Worms, H. GSK-3β targets Cdc25A for ubiquitin-mediated proteolysis and GSK-3β inactivation leads to Cdc25A overproduction in human cancers. *Cancer Cell* 13: 36-47, 2008. Yang, J-Y., Zong, C.S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J-Y., Lai, C-C., Chang, C-J., Huang, W-C., Huang, H., Kuo, H-P., Lee, D-F., Li, L-Y., Lien H-C., Cheng, X, Chang, K-J., Hsiao, C-D., Tsai, F-J., Tsai, C-H., Sahin, AA., Muller, WJ., Mills, GB., Yu, D., Hortobagyi, GN. and Hung, M-C. Erk promotes tumorigenesis by inhibiting Foxo3a via MDM2-mediated degradation. *Nature Cell Biology10:138-148, 2008. Zhang, W., Tsan, R., Wu, Q., Huang, W-C., Chiu, C-H., Fidler, I.J. and *Hung, M-C. Survival of cancer cells is maintained by kinase-independent EGFR. *Cancer Cell* 13:383-393, 2008. Co-Corresponding authors. Lee, D-F., Kuo, H-P., Liu, M., Chou, C-K., Xia, W., Du, Y., Shen, J., Shen, J., Chen, C-T., Huo, L., Hsu, M-C., Li, C-W., Ding, Q., Liao, T-L., Lai, C-C., Lin, A-C. Chang, Y-H, Tsai, S-F., Li, L-Y. and Hung, M-C.* KEAP1 E3 ligase-mediated down regulation of NF-kB signaling by targeting IKKb. *Molecular Cell* 36: 131-140, 2009. Liu, S., Umezu-Goto, M., Murph, M., Lu, Y., Liu, W., Zhang, F., Yu, S., Stephens, L.C., Cui, Z., Murrow, G., Coombes, K., Muller, W., Hung, M-C., Perou, C. M., Lee, A. V., Fang, X. and Mills, G. B. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion and metastasis. *Cancer Cell* 15:539-550, 2009. Lu, J, Guo, H, Treekitkarnmongkol, W, Li, P, Zhang, J, Shi, B, Ling C, Zhou, X, Chen, T, Chiao, P, Feng X, Seewaldt, V, Muller, W, Sahin, A, Hung, M-C and Yu, D. 14-3-3ζ cooperates with ErbB2 to promote progression of ductal carcinoma in situ to invasive breast cancer by inducing epithelial-mesenchymal transition. *Cancer Cell* 16:195-207, 2009. Hildebrandt, MAT., Yang, H., Hung, M-C., Izzo, JG., Huang, M., Lin, J., Ajani, JA and Wu, X. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. *Journal of Clinical Oncology27:857-871 (Epub Jan 21), 2009. Jiralerspong, S., Palla, S., Girodano, S., Meric-Bernstam, F., Liedtke, C., Barnett, C., Hsu, L. Hung, M-C.,* Hortobagyi, G and Gonzalez-Angulo, A.M. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. *Journal of Clinical Oncology* (Epub June 1), 27: 3297-3302, 2009. Lu C., Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MMK, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung M-C, Lopez-Berestien G, Sood AK. Regulation of tumor angiogenesis by EZH2. *Cancer Cell* 18 (2): 185-197, 2010. Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT, Mills GB, Hortobagyi GN, Mendelsohn J, Hung MC, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated activation of Src and inactivation of PTEN. *Cancer Cell* 18:423-435, 2010. Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung M-C, Pandolfi PP and Lin HK. Deciphering the transcription complex critical for RhoA gene expression and cancer metastasis. *Nature Cell Biology, 12(5): 457-467 (Epub online April 11), 2010. Huo LF, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding QQ, Chen CH, Tsai CH, Hung M-C. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc. Natl. Acad. Sci. 107(37):16125-16130 (Epub online August 27), 2010. Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cell. Nature Cell Biology13 (1):87-94(Epub online December 5, 2010), 2011. Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a noncanonical histone signature to breast cancer. Nature* Dec 16; 468(7326):927-932, 2010. Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast cancer tumor initiating cells through activation of RAF-b-catenin signaling. *Cancer Cell* 19 (1):86-100, (Epub online Jan 5), 2011. Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between R1175 methylation and Y1173 phosphorylation negatively modulates EGFR-mediated ERK activation. *Nature Cell Biology13(2):174-181, (Epub online Jan 23), 2011. Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu J, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition (EMT) and stem cell properties through modulation of miRNAs. Nature Cell BiologyMar;13(3):317-323 (Epub online Feb 20), 2011. Tsai KS, Yang SH, Lei YP, Tsai CC, Chen HW, Hsu CY, Chen LL, Wang HW, Miller SA, Chiou SH, Hung MC and Hung SC. Mesenchymal stem cells within tumors enhance xenograft tumor formation in colorectal cancer. GastroenterologySep;141(3):1046-1056 (Epub online May 31), 2011. Co-corresponding authors Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC Jr. Dasatinib-enhanced paclitaxel cytotoxicity by upregulation of p27Kip1 and downregulation of Bcl-2 and CDK1. *JNCI* Sep 21;103(18):1403-1422 (Epub online August 2), 2011. Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. *Cancer Cell* Sep 13;20(3):341-356, 2011. Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai CC, Li HB, Yen CJ, Kuo HP, Lee DF, Lang JY, Huo LF, Cheng XY, Chen YJ, Li CW, Jeng LB, Hsu J, Li LY, Tan A, Curley SA, Ellis LM, DuBois RN and Hung MC. Genes that mediate colorectal cancer metastasis to liver. Journal of Clinical Investigation Nov 1;121(11):4526-4536 (Epub online Oct 10), 2011. Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC. IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. *Molecular Cell* 45(2):171-184 (Epub on line Dec 20, 2011), 2012. Wang Y, Ding QQ, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Miller SA, Wang X, Lee DF, Hsu JL, Hsu JM, Huo LF, LaBaff AM, Liu DP, Huang TH, Lai CC, Tsai FJ, Chang WC, Chen CH, Wu TT, Buttar NS, Wang KK, Wu Y, Wang H, Ajani J, Hung MC. The crosstalk of mTOR/S6K1 and Hedgehog pathways. *Cancer Cell* 21, 374–387 (DOI 10.1016/j.ccr.2011.12.028), 2012. Ling J, Kang Y, Lee D-F, Xia Q, Zhao R, Chang Z, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/b/NF-kB activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. *Cancer Cell* Jan 17, 21:105-120, 2012. Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH. Rac1 activation mediates Twist1-induced cancer cell migration. *Nature Cell Biology* 14:366-374, (Epub March 11, doi: 10.1038/ncb2455), 2012. PMID: 22407364. Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KC, Flores LG, Shao Y, Hazel JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama K, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis. *Cell* 149:1098-1111, 2012. Lee DF, Su J, Ang YS Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJK, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moor KA, Snoeck HW, Ma’ayan A, Schaniel C, Lemischka IR. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. *Cell Stem Cell* Aug 3, 11(2):179-194, 2012. Chen D, Su Y, Wei Y, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. *Nature Medicine* 18(10):1511-1517, (EPub online Sept 23), 2012. Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O’Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 de-stabilization. *Genes and Development* 27(3):274-287, 2013. Dong C, Yuan T, Wu Y, Wang Y, Fan TWM, Miriyala S, Lin Y, Yao J, Shi J, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of RBP1 by snail-mediated repression provides metabolic advantages in basal-like breast cancer. *Cancer Cell* (Epub online Feb 7, doi:pii: S1535-6108(13)00042-1. 10.1016/j.ccr.2013.01.022), 2013. Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim SO, Du Y, Wang Y, Chang WC, Chen CH, Hsu JL, Wu Y, Lam YC, James BP, Liu X, Liu CG, Patel DJ, Hung MC. 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Nature CommFeb 5: 12:832, 2021 Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC.* Tyro3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin InvestApr 15;131(8):139434, 2021. Lee HH†, Wang YN†, Yang WH†, Xia W, Wie Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL, Yamaguchi, Pang D, Hortobagyi GN, Yu D, Hung MC. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nature Communications 12(1):2788, (May 13 epub online), 2021. Deng Y, Xia Xi, Zhao Y, Zhao Z, Martinez C, Yin W, Yao J, Hang Q, Wu W, Zhang J, Yu Y, Xia W, Yao F, Zhao D, Sun Y, Ying H, Hung MC, Li M. Glucocorticoid receptor regulates PD-L1 and MHCI in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. *Nat Comm* 12:7041, 2021.

SELECTED PUBLICATIONS

Xing, X., Wang, S-C., , Xia, W.Y., Zou, Y., Shao, R., Kwong, K.Y., Yu, Z., Zhang, S., Miller, S., Huang, L., and Hung, M.-C. The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nature Medicine6:189-195, 2000.
Lin, S.-Y., Xia, W., Wang, J. C., Kwong, K-Y., Spohn, B., Wen, Y., Pestell, R.G. and Hung, M.-C. b-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc. Natl. Acad. Sci. 97:4262-4266, 2000.
Zhou, B.P., Liao, Y., Xia, W., Spohn, B., Lee, M.H., and Hung, M.-C. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nature Cell Biology 3(3):245-252, 2001.
Lin, S.Y., Makino, K., Xia, W., Matin, A., Wen, Y., Kwong, K.Y., Bourguignon, L., and Hung, M.-C. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nature Cell Biology 3:803-808, 2001.
Zhou, B.P., Liao, Y., Xia, W., Zou, Y., Spohn, B., and Hung, M.-C. HER-2/neu induces ubiquitination via Akt-mediated MDM2 phosphorylation. Nature Cell Biology 3:973-982, 2001.
Hortobagyi, G.N., Ueno, N.T., Xia, W., Zhang, S., Wolf, J.W., Putnam, J.B., Weiden, P.L., Willey, J.S., Carey, M., Warner, D.L., Payne, J.Y., Tucker, S.D., Bartholomeusz, C., Kilbourn, R.G., De Jager, R.L., Sneige, N., Katz, R.L., Daifuku, R., Ibrahim, N.K., Murray, J.L., Theriault, R.L., Valero, V., Gershenson, D.M., Bevers, M.W., Huang, L., Lopez-Berestein, G. and Hung, M.-C. Cationic liposome-mediated adenovirus type 5 E1A gene transfer to human breast and ovarian cancer cells and its biological effects: A phase I clinical trial. J. Clin. Oncol. 19:3422-3433, 2001.
Deng, J., Miller, S. A., Wang, H.-Y., Xia, W., Wen, Y., Zhou, B., Lin, S.-Y., Li, Yan and Hung, M.-C. b-Catenin interacts with and inhibits NF-kB in human colon and breast cancers. Cancer Cell 2: 323-334,2002.
Tan, M., Jing, T., Lan, K.-H., Neal, C.L., Li, P., Lee, S., Fang, E., Nagata, Y., Liu, J., Arlinghaus, R., Hung, M.-C. and Yu, D. Phosphorylation on tyrosine-15 of p34cdc2 by ErbB2 inhibits p34Cdc2 activation and is involved in resistance to Taxol-induced apoptosis. Molecular Cell 9: 993-1004, 2002*. * Selected as a cover on May issue.
Asada, S., Choi, Y., Yamada, M., Wang, S.-C., Hung, M.-C., Qin, J. and Uesugi, M. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc. Natl. Acad. Sci. USA 99:12747-12752, 2002.
Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X.-M., Lardy, H., Huang, K.-E., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., Xing, L., Boyce, B.F., Hung, M-C., Zhang, S. and Chang, C. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc. Natl. Acad. Sci. USA 99: 13498-13503, 2002.
Feng, Z., Hu, W., Chen, J. X., Pao, A., Li, H., Rom, W. N., Hung, M.-C., Adair, G.M. and Tang, M.-S. Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J. Natl. Cancer Inst. 94:1527-1536, 2002*. *Accompanied by Editorial “Etiology of the mutational spectrum of ras gene in human carcinomas” by Kelley, M. J. and Littman, S. J. J. Natl. Cancer Inst. 94:1516-1517, 2002. Accompanied by BBC news embargo “Carcinogen in cigarettes causes mutation linked to lung cancer” on October 14, 2002.
Hu, M.C-T, Lee, D.-F., Xia, W., Golfman, L., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S, Hanada, N., Saso, H., Kobayashi R. and Hung, MC. IkB kinase promotes tumourigenesis through inhibition of Forkhead transcription factor FOXO3a. Cell 117:225-237, 2004.
Wang, S-C., Lien, H-C., Xia, W., Chen, I-F., Lo, H-W., Wang, Z., Ali-Seyed, M., Bartholomeusz, G., Ou-Yang, F., Giri, D.K. and Hung, MC. Binding at and transactivation of COX-2 promoter by nuclear tyrosine kinase receptor ErbB2. Cancer Cell 6:251-261, 2004.
Zhou, B.P., Deng, J., Xia, W., Xu, J., Li, Y.M., Gundaz, M. and Hung, MC. Dual regulation of Snail by GSK-3b-mediated phosphorylation in control of epithelial-mesenchymal transition. Nature Cell Biology6:931-940, 2004.
Nagata, Y., Lan, K-H., Zhou, X., Tan, M., Esteva, F.J., Sahin, A.A., Klos, K.S., Li, P., Monia, B.P., Nguyen, N.T., Hortobagyi, G.N., Hung, MC and Yu, D. PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6:117-127, 2004*. *Accompanied by many news release—Nature online news: www.nature.com/news; CNN news on Aug. 23, 2004; NBC Universal news on Aug. 23, 2004; MD Anderson Special News Release, Aug. 23, 2004; National Post of Canada, Aug. 24, 2004; Cancer Biology and Therapy, Aug. 24, 2004; The World Journal-- New York, Aug. 24, 2004; BCN (BreastCancer.Net) News, Aug. 24, 2004; www.reutershealth.com. ; Medical Post- Toronto; Shingtao Daily (a Chinese news paper); and Houston Chronicle.
Li, Y.M., Pan, Y., Wei, Y., Cheng, X., Zhou, B., Tan, M., Zhou, X., Xia, W., Hortobagyi, G.N., Yu, D. and Hung, MC Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell6:459-469, 2004.
Lo, H-W., Hsu, S-C., Ali-Seyed, M., Gunduz, M., Xia, W., Wei, Y., Bartholomeusz, G., Shih, J-Y.,and Hung, M-C. Nuclear interaction of EGFR and STAT3 in the activation of iNOS/NO pathway. Cancer Cell 7:575-589, 2005.
Ding, Q., Xia W., Liu, J-C., Yang, J-Y., Lee, D-F., Xia, J., Bartholomeusz, Li, Y., Pan, Y., Li, Z., Bargou, RC., Qin, J., Lai, C-C., Tsai, F-J. Tsai, C-H. and Hung, M-C. Erk1/2 associates with and primes GSK-3b for its inactivation resulting in upregulation of b-catenin. Molecular Cell 19:159-170, 2005.
Cha, T-L., Zhou, BP., Xia, W., Wu, Y., Yang, C-C., Chen, C-T., Ping, B. Otte, A.P. and Hung, M-C. Akt-mediated phosphorylation of EZH2 augments methylation of lysine 27 in histone H3. Science 310:306-310, 2005.
Wang, S-C., Nakajima, Y., Yu, Y-L., Li, L-Y., Chen, C-T, Hawke, D., Kobayashi, R. and Hung, M-C. Tyrosine phosphorylation controls protein stability of PCNA. Nature Cell Biology. 8:1359-1368, 2006.
Su, J-L., Yang, P-C., Shih, J-Y., Yang, C-Y., Wei, L-H., Hsieh, C-Y., Chou, C-H., Jeng, Y-M., Wang, M-Y., Chang, K-J., Hung, M-C. and Kuo, M-L. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 9:209-223, 2006.
Huang, W-C., Ju, T-K., *Hung, M-C. and *Chen, C-C. Phosphorylation of CBP by IKKa promotes cell growth by switching the binding preference of CBP from p53 to NF-kB. Molecular Cell26:75-87, 2007. *co-corresponding author.
Xie, X., Xia, W., Li, Z., Kuo, H-P.,Liu, Y., Li, Z., Ding, Q., Zhang, S., Spohn, W., Yang, Y., Wei, Y., Lang, J-Y., Evans, D.B., Chiao, P.J., Abbruzzese J.L. and Hung, M-C. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell, 12:52-65, 2007.
Lee, D-F., Kuo, H-P., Chen, C-T., Hsu, J-M., Sun, H-L., Chou, C-K., Wei, Y., Li, L-Y.,Ping, B., Huang, W-C., He, X., Hung, J-Y., Lai, C-C., Ding, Q., Su, J-L., Yang, J-Y., Sahin, A.A., Hortobagyi, G.N., Tsai, F-J., Tsai, C-H. and Hung, M-C. Suppression of TSC1 by IKKb confers tumor angiogenesis through the mTOR pathway. Cell130:440-455, 2007.
Wang, R-H., Zheng, Y., Kim, H-S., Xu, X., Cao, L., Luhasen, T., Lee, M-H., Xiao, C., Vassilopoulos, A., Chen, W., Gardner, K., Man, Y-G., Hung, M-C., Finkel, T. and Deng, C-X. Interplay among BRAC1, SIRT1 and Survivin during BRAC1-associated tumorigenesis. Molecular Cell, 32:11-20, 2008*. *Previews: “SIRTing through breast cancer is just a survivin’ game” by Jianyuan Luo and Dario C. Altieri, Molecular Cell 32:159-160, 2008.
Kang, T., Wei, Y., Honaker, Y., Yamaguchi, H., Appella, E., Hung, M-C. and Piwnica-Worms, H. GSK-3β targets Cdc25A for ubiquitin-mediated proteolysis and GSK-3β inactivation leads to Cdc25A overproduction in human cancers. Cancer Cell 13: 36-47, 2008.
Yang, J-Y., Zong, C.S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J-Y., Lai, C-C., Chang, C-J., Huang, W-C., Huang, H., Kuo, H-P., Lee, D-F., Li, L-Y., Lien H-C., Cheng, X, Chang, K-J., Hsiao, C-D., Tsai, F-J., Tsai, C-H., Sahin, AA., Muller, WJ., Mills, GB., Yu, D., Hortobagyi, GN. and Hung, M-C. Erk promotes tumorigenesis by inhibiting Foxo3a via MDM2-mediated degradation. Nature Cell Biology10:138-148, 2008.
Zhang, W., Tsan, R., Wu, Q., Huang, W-C., Chiu, C-H., *Fidler, I.J. and *Hung, M-C. Survival of cancer cells is maintained by kinase-independent EGFR. Cancer Cell 13:383-393, 2008. *Co-Corresponding authors.
Lee, D-F., Kuo, H-P., Liu, M., Chou, C-K., Xia, W., Du, Y., Shen, J., Shen, J., Chen, C-T., Huo, L., Hsu, M-C., Li, C-W., Ding, Q., Liao, T-L., Lai, C-C., Lin, A-C. Chang, Y-H, Tsai, S-F., Li, L-Y. and Hung, M-C. KEAP1 E3 ligase-mediated down regulation of NF-kB signaling by targeting IKKb. Molecular Cell 36: 131-140, 2009.
Liu, S., Umezu-Goto, M., Murph, M., Lu, Y., Liu, W., Zhang, F., Yu, S., Stephens, L.C., Cui, Z., Murrow, G., Coombes, K., Muller, W., Hung, M-C., Perou, C. M., Lee, A. V., Fang, X. and Mills, G. B. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion and metastasis. Cancer Cell 15:539-550, 2009.
Lu, J, Guo, H, Treekitkarnmongkol, W, Li, P, Zhang, J, Shi, B, Ling C, Zhou, X, Chen, T, Chiao, P, Feng X, Seewaldt, V, Muller, W, Sahin, A, Hung, M-C and Yu, D. 14-3-3ζ cooperates with ErbB2 to promote progression of ductal carcinoma in situ to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell 16:195-207, 2009.
Hildebrandt, MAT., Yang, H., Hung, M-C., Izzo, JG., Huang, M., Lin, J., Ajani, JA and Wu, X. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. Journal of Clinical Oncology27:857-871 (Epub Jan 21), 2009.
Jiralerspong, S., Palla, S., Girodano, S., Meric-Bernstam, F., Liedtke, C., Barnett, C., Hsu, L. Hung, M-C., Hortobagyi, G and Gonzalez-Angulo, A.M. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. Journal of Clinical Oncology (Epub June 1), 27: 3297-3302, 2009.
Lu C., Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MMK, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung M-C, Lopez-Berestien G, Sood AK. Regulation of tumor angiogenesis by EZH2. Cancer Cell 18 (2): 185-197, 2010.
Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT, Mills GB, Hortobagyi GN, Mendelsohn J, Hung MC, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated activation of Src and inactivation of PTEN. Cancer Cell 18:423-435, 2010.
Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung M-C, Pandolfi PP and Lin HK. Deciphering the transcription complex critical for RhoA gene expression and cancer metastasis. Nature Cell Biology, 12(5): 457-467 (Epub online April 11), 2010.
Huo LF, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding QQ, Chen CH, Tsai CH, Hung M-C. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc. Natl. Acad. Sci. 107(37):16125-16130 (Epub online August 27), 2010.
Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cell. Nature Cell Biology13 (1):87-94(Epub online December 5, 2010), 2011.
Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a noncanonical histone signature to breast cancer. Nature Dec 16; 468(7326):927-932, 2010.
Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast cancer tumor initiating cells through activation of RAF-b-catenin signaling. Cancer Cell 19 (1):86-100, (Epub online Jan 5), 2011.
Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between R1175 methylation and Y1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nature Cell Biology13(2):174-181, (Epub online Jan 23), 2011.
Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu J, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition (EMT) and stem cell properties through modulation of miRNAs. Nature Cell BiologyMar;13(3):317-323 (Epub online Feb 20), 2011.
Tsai KS, Yang SH, Lei YP, Tsai CC, Chen HW, Hsu CY, Chen LL, Wang HW, Miller SA, Chiou SH, *Hung MC and *Hung SC. Mesenchymal stem cells within tumors enhance xenograft tumor formation in colorectal cancer. GastroenterologySep;141(3):1046-1056 (Epub online May 31), 2011. *Co-corresponding authors
Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC Jr. Dasatinib-enhanced paclitaxel cytotoxicity by upregulation of p27Kip1 and downregulation of Bcl-2 and CDK1. JNCI Sep 21;103(18):1403-1422 (Epub online August 2), 2011.
Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell Sep 13;20(3):341-356, 2011.
Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai CC, Li HB, Yen CJ, Kuo HP, Lee DF, Lang JY, Huo LF, Cheng XY, Chen YJ, Li CW, Jeng LB, Hsu J, Li LY, Tan A, Curley SA, Ellis LM, DuBois RN and Hung MC. Genes that mediate colorectal cancer metastasis to liver. Journal of Clinical Investigation Nov 1;121(11):4526-4536 (Epub online Oct 10), 2011.
Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC. IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Molecular Cell 45(2):171-184 (Epub on line Dec 20, 2011), 2012.
Wang Y, Ding QQ, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Miller SA, Wang X, Lee DF, Hsu JL, Hsu JM, Huo LF, LaBaff AM, Liu DP, Huang TH, Lai CC, Tsai FJ, Chang WC, Chen CH, Wu TT, Buttar NS, Wang KK, Wu Y, Wang H, Ajani J, Hung MC. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell 21, 374–387 (DOI 10.1016/j.ccr.2011.12.028), 2012.
Ling J, Kang Y, Lee D-F, Xia Q, Zhao R, Chang Z, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/b/NF-kB activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell Jan 17, 21:105-120, 2012.
Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH. Rac1 activation mediates Twist1-induced cancer cell migration. Nature Cell Biology 14:366-374, (Epub March 11, doi: 10.1038/ncb2455), 2012. PMID: 22407364.
Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KC, Flores LG, Shao Y, Hazel JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama K, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis. Cell 149:1098-1111, 2012.
Lee DF, Su J, Ang YS Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJK, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moor KA, Snoeck HW, Ma’ayan A, Schaniel C, Lemischka IR. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell Aug 3, 11(2):179-194, 2012.
Chen D, Su Y, Wei Y, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nature Medicine 18(10):1511-1517, (EPub online Sept 23), 2012.
Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O’Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 de-stabilization. Genes and Development 27(3):274-287, 2013.
Dong C, Yuan T, Wu Y, Wang Y, Fan TWM, Miriyala S, Lin Y, Yao J, Shi J, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of RBP1 by snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell (Epub online Feb 7, doi:pii: S1535-6108(13)00042-1. 10.1016/j.ccr.2013.01.022), 2013.
Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim SO, Du Y, Wang Y, Chang WC, Chen CH, Hsu JL, Wu Y, Lam YC, James BP, Liu X, Liu CG, Patel DJ, Hung MC. EGFR modulates miRNA maturation in response to hypoxia through phosphorylation of Ago 2. Nature May 16; 497(7449):383-387 (epub online May 1, doi: 10.1038/nature12080.), 2013.
News in Cancer Discovery “EGFR Regulates microRNA Processing via Modification of AGO2”, May 9, 2013 (DOI: 10.1158/2159-8290.CD-RW2013-099);
“MICRORNA Lacking in Maturity” Nicola McCarthy, Nature Reviews Cancer (published online 16 May 2013; doi:10.1038/nrc3534)
Editor’s Choice “Hypoxia Prevents miRNA Processing” Nancy R. Gough, Science Signaling 21 May, 2013 Vol 6, Issue 276, p. ec111 (doi: 10.1126/scisignal.2004336)
Chan CH, Morrow JK, Li CF, GaoY, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis C, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cells and cancer progression. Cell 154:556-568, 2013.
Wagner K, Alam H, Dhar S, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani A, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach J, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling in NSCLC. Journal of Clinical Investigation 123 (12): 5231-5246, (pii: 68642. doi: 10.1172/JCI68642. Epub online Nov 8), 2013.
Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitination and stabilization of PTEN by USP13. Nature Cell Biology Dec; 15(12):1486-1494 (doi:10.1038/ncb2874, Epub Nov 24), 2013.
Huang TH, Huo LF, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, Shen J, Lee HH, Lee PC, Wu Y, Chen CH, Hung MC. EGFR potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell 23(6):796-810, 2013.
Chiou GY, Chien CS, Wang ML, Chen MT, Yang YP, Yu YL, Chien Y, Chang YC, Shen CC, Chio CC, Lu KH, Ma HI, Chen KH, Liu DM, Miller SA, Chen YW, Huang PI, Shin YH, *Hung MC, *Chiou SH. Epigenetic regulation of the MiR142-3p/Interleukin-6 circuit in glioblastoma. Molecular Cell Dec 12; 52(5):693-706, (doi:10.10.16/j.molcel,2013.11.009), 2013. *Co-corresponding authors
Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Kuo SC, Chen CH, Yu YL*, Hung MC*. EGFR modulates DNA synthesis and repairs through Tyr phosphorylation of Histone H4. Development Cell 30(2):224-237, (doi: 10.1016/j.devcel.2014.06.008), 2014. *co-corresponding authors.
Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Medema RH, Hung MC, Huang S. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-b-dependent cancer metastasis. J Clin Invest. 124(2):564-579 (pii:71104, doi:10.1172/JCI71104, Epub Online Jan 2), 2014.
Zhang K, Chou CK, Xia X, Hung MC, Qin L. Block-cell-printing for live single-cell printing. Proc. Natl. Acad. Sci. 111(8): 2948-2953, (doi: 10.1073/pnas.1313661111, Epub online Feb 10),2014.
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#*Xu D, #Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, *Hung MC, *Lu Z. The gluconeogenic enzyme PCK1phosphorylates INSIG1/2 for lipogenesis. Nature 580(7804):530-535 (Epub April 8), 2020.
Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JH, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC. PD-L1-mediated Gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumor necrosis. Nature Cell Biology, Oct;22(10):1264-1275 (Sept 14 Epub online) 2020. https://doi.org/10.1038/s41556-020-0575-z. PMC7653546. Comments: “Cell Death: PD-L1 controls cancer pyroptosis” by Blasco MT, Gomis RR. Nature Cell Biol Oct 22:1155-1161, 2020
Liu CX†, Zha Z†, Zhou C†, Chen Y, Xia W, Wang YN, Lee HH, Yin Y, Yan M. Chang CW, Qiu Y, Li H, Li CW, Hsu JM, Hsu JL, Wang SC, Ren N*, Hung MC*. Ribonuclease 7-driven activation of ROS1 is a new potential therapeutic target in hepatocellular carcinoma. J of Hepatology, 5(20):33674-33676, 2020.
*Yang R†, Sun L†, Li CF, Wang YH, Yao J, Li H, Yan M, Chang WC, Hsu JM, Cha JH, Hsu JL, Chou CW, Sun X, Deng Y, Chou CK, Yu D, *Hung MC. Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. †Equal contribution *co-corresponding authors. Nature CommFeb 5: 12:832, 2021
Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC. Tyro3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin InvestApr 15;131(8):139434, 2021.
Lee HH†, Wang YN†, Yang WH†, Xia W, Wie Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL, Yamaguchi, Pang D, Hortobagyi GN, Yu D, Hung MC. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nature Communications 12(1):2788, (May 13 epub online), 2021.
Deng Y, Xia Xi, Zhao Y, Zhao Z, Martinez C, Yin W, Yao J, Hang Q, Wu W, Zhang J, Yu Y, Xia W, Yao F, Zhao D, Sun Y, Ying H, Hung MC*, Li M*. Glucocorticoid receptor regulates PD-L1 and MHCI in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nat Comm 12:7041, 2021.

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