Member » University Consultant

Ta-Jen Liu, Ph.D

Ta-Jen Liu, Ph.D

Ta-Jen Liu, Ph.D



Current Position

  • University Consultant



Year Education
6/89-6/92 Postdoc fellow, 6/89-6/92, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX
1989 Ph.D., 1989, Molecular Biology, Florida State University, Tallahassee, FL
1980 B.S., 1980, Chemistry, Fu-Jen Catholic University, Taiwan,


Academic Appointment

Year Academic Appointment
1995-1996 Instructor, Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX. 1995-1996.
1996-1997 Assistant Professor and Assistant Biologist, Department of Head and Neck Surgery, The University of Texas, M.D. Anderson Cancer Center, Houston, TX. Full member, The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 1996-1997
1997-2005 Assistant Professor and Assistant Biologist, Department of Neuro-Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX. Full member, The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 1997-2005
2005-2007 Associate Professor, Department of Neuro-Oncology, The University of Texas Anderson Cancer Center, Houston, TX. Full member, The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 2005-2007


Administrative Appointment

Year Administrative Appointment
2007-2010 Project Manager, Office of Global Academic Programs, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, 2007-2010
2010-2019 Project Director, Office of Global Academic Programs, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, 2010-2019
2019-Present Consultant. China Medical University, Taichung, Taiwan 2019-Present



Articles in Peer-Reviewed Journals
Liu T-J, Liu YC, Liu LK. Structure of the 1:1 adduct between titanium (IV) chloride and pentanedinitrile. Acta Cryst C42: 289-291, 1986.
Liu T-J, Liu L, Marzluff WF, Mouse histone H2a and H2b genes: four functional genes and a pseudogene undergoing gene conversion with a closely linked functional gene. Nucleic Acids Res 15(7):3023-3039,1987.
Levine BJ, Liu T-J , Marzluff WF, Skoultchi AI. Differential expression of individual members of the histone multigene family due to sequences in the 5’ and 3’ regions of the genes. Mol .Cell .Biol. 8:1887-1895, May 1988.
Liu T-J, Levine BJ, Skoultchi AI, Marzluff WF. The efficiency of 3’ end formation contributes to the relative level of different histone mRNAs. Mol. Cell.Biol. 9: 3499- 3508, 1989.
Pandey, NB, Chodchoy, N, Liu, T-J, Marzluff, WF, Introns in histone genes alter the distribution of 3’ ends. Nucleic Acids Res. 18(11):3161-3170,1990.
Liu T-J, Kay MA, Darlington GJ, Woo SLC. Reconstitution of enzymatic activity in hepatocytes of phenylalanine hydroxylase deficient mice. Somat Cell Mol Genet. 18(1):89-96 1992.
Kay MA, Baley P, Rothenberg S, Leland F, Fleming L, Ponder KP, Liu T-J, Finegold M, Darlington G, Pokorny , Woo SLC. Expression of human alpha-1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes. Proc. Natl. Acad. Sci. USA 89(1):89-93.1992.
Kay MA, Li, Qiutang, Liu T-J, Leland F, Toman C, Finegold M, Woo SLC. Hepatic gene therapy: persistent expression of human a1-antitrypsin in mice after direct gene deliver in vivo. Human Gene Therapy Vol. 3, No. 6, pp. 641-647. 1992.
Liu T-J, Zhang W-W, Taylor DL, Roth JA, Goepfert H, Clayman GL. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Research 54(13):3644-3649, 1994.
Clayman G L, El-Naggar AK, Roth JA, Zhang W-W, Goepfert H., Liu T-J. In vivo Molecular Therapy with p53 Adenovirus for Microscopic Residual Head and Neck Squamous Carcinoma. Cancer Research 55(1): 1-6, 1995.
Liu T-J, El-Naggar AK, McDonnell TJ, Steck KD, Wang M, Taylor DL, ClaymanGL.Apoptosis induction mediated by wild-type p53 adenovirus gene transfer in squamous cell carcinoma of the head and neck.Cancer Research; 55:3117-3122, 1995.
Russell N. Beckhardt, Nobutaka Kiyokawa, Lei Xi, T-J Liu, Mien-Chie Hung,Adel K.El-Naggar, Hua-Zhong Zhang, Gary L. Clayman. HER-2/neu Oncogene Characterization in Head and Neck Squamous Cell Carcinoma. Archives of Otolaryngology-Head and Neck Surgery; 121:1265-1270, 1995.
Janot F, El-Naggar AK, Morrison RS, Liu T-J, Taylor DL, Clayman GL. Expression of basic fibroblast growth factor in squamous cell carcinoma of the head and neck is associated with degree of histologic differentiation. International Journal of Cancer 64:1-7, 1995.
Clayman GL, Trapnell BC, Mittereder N, Liu T-J, Eicher S, Zhang S, and Shillitoe EJ. Transduction of normal and malignant oral epithelium by an adenovirus vector: The effect of dose and treatment time on transduction efficiency and tissue penetration. Cancer Gene Therapy; 2:105-111, 1995.
Clayman GL, Liu T-J, Overholt M, Mobley SR, Wang M, Janot F, Goepfert H. Gene therapy for head and neck cancer. Comparing the tumor suppressor gene p53 and a cell cycle regulator WAF1/C1P1 (p21). Archives of Otolaryngology-Head and Neck Surgery, 122:489-493, 1996.
Fueyo J, Gomez-Manzano C, Yung WKA, Clayman GL, Liu T-J, Bruner J, Levin VA, and Kyritsis AP. Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene; 12:103-110, 1996.
Eicher SA, Clayman GL, Liu T-J, Shillitoe EJ, Storthz, KA, Roth JA, and Lotan R. Evaluation of topical gene therapy for head and neck squamous cell carcinoma in an organotypic model. Clinical Cancer Research 2: 1659-1664, 1996.
T-J Liu, Mark Overholt, Dorothy L.Taylor, Mary Wang, Adel K. El-Naggar,Ed Shillitoe, Karen Adler-Storthz, Wei-Wei Zhang, Jack A. Roth, and Gary L. Clayman.Head and Neck Squamous Cell Growth Suppression Using Adenovirus-p53- FLAG: An Effective Marker for Gene Therapy Trials. Clinical Cancer Research3: 185-191, 1997.
Gotoh A. Kao C. Ko SC. Hamada K. Liu T-J. Chung LW . Cytotoxic effects of recombinant adenovirus p53 and cell cycle regulator genes (p21 WAF1/CIP1 and p16CDKN4) in human prostate cancers. Journal of Urology. 158(2):636-41, Aug. 1997.
Hunt, KK., Deng, J., Liu T-J., Swisher, SG., Clayman, GL., and Hung M-C. Adenovirus- Mediated Overexpression of the Transcription Factor E2F-1 Induces Apoptosis in Human Breast and Ovarian Cell Lines and Does not require p53. Cancer Research :57:4722- 4726, 1997.
Mobley, S. R., Liu, T.J., Hudson, J. M., and Clayman, G. L. In vitro growth suppression by adenoviral transduction of p21 and p16 in squamous cell carcinoma of the head and neck: a research model for combination gene therapy, Archives of Otolaryngology -- Head & Neck Surgery. 124: 88-92, 1998.
Fueyo, J., Gomez-Manzano, C., Yung, W. K., Liu, T. J., Alemany, R., Bruner, J. M., Chintala, S. K., Rao, J. S., Levin, V. A., and Kyritsis, A. P. Suppression of human glioma growth by adenovirus-mediated Rb gene transfer. Neurology. 50: 1307-15, 1998.
Fueyo J, Gomez-Manzano C, Yung WKA, Liu T-J, Alemany R, McDonnell TJ, Shi X, Rao JS, Levin VA, and Kyritsis AP. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nature Medicine 4 (6) 1-6, June 1998.
Ying C. Henderson, T-J Liu, Gary L Clayman. A simple and sensitive method for detecting adenovirus in serum and urine. J. of Virological Methods 71: 51-56, 1998.
Frank, D. K., Frederick, M. J., Liu, T.-J., and Clayman, G. L. Bystander effect in the adenovirus-mediated wild-type p53 gene therapy model of human squamous cell carcinoma of the head and neck. Clin Cancer Res. 4: 2521-8, 1998.
Frank, D. K., Liu, T.-J., Frederick, M. J., and Clayman, G. L. Combination E2F-1 and p53 gene transfer does not enhance growth inhibition in human squamous cell carcinoma of the head and neck, Clin Cancer Res. 4: 2265-72, 1998.
Clayman, G. L., el-Naggar, A. K., Lippman, S. M., Henderson, Y. C., Frederick, M., Merritt, J. A., Zumstein, L. A., Timmons, T. M., Liu, T. J., Ginsberg, L., Roth, J. A., Hong, W. K., Bruso, P., and Goepfert, H. Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma, J Clin Oncol. 16: 2221-32, 1998.
Liu, T. J., Wang, M., Breau, R. L., Henderson, Y., El-Naggar, A. K., Steck, K. D., Sicard, M. W., and Clayman, G. L. Apoptosis induction by E2F-1 via adenoviral- mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines. Cancer Gene Ther. 6: 163-71, 1999.
Chou MF; Shelat HS; Liu TJ; Willerson JT; Zoldhelyi P. Induction of apoptosis and growth suppression of human VSMC in vitro by gene transfer of the transcription factor E2F-1. Circulation , Vol 98, Iss 17, pp 3139-, 1998.
Zuxing Kan and T-J, Liu. Video microscopy of tumor metastasis: Using the green fluorescent protein (GFP) gene as a cancer-cell-labeling system. Clinical & Experimental Metastasis 1:1-8, 1999.
Hai Liang Yang, Yan Bin Dong, Mary Jane Elliott, Ta-Jen Liu, Cesar Atienza, Jr., Ariel Stilwell,Kelly M. McMasters Adenovirus-mediated E2F-1 Gene Transfer Inhibits MDM2 Expression and EfficientlyInduces Apoptosis in MDM2-overexpressing Tumor Cells. Clin Cancer Res 5, 2242-2250, August 1999.
Dong, Y. B., Yang, H. L., Jane, M., Liu, T. J., Stilwell, A., Atienza, C., Jr., and McMasters, K. M. Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells, Cancer. 86: 2021-33, 1999.
Yang HL, Dong YB, Elliott MJ, Liu TJ, McMasters KM. Caspase activation and changes in Bcl-2 family member protein expression associated with E2F-1-mediated apoptosis in human esophageal cancer cells. Clin Cancer Res 6(4):1579-89, 2000.
Itoshima T, Fujiwara T, Waku T, Shao J, Kataoka M, Yarbrough WG, Liu TJ, Roth JA, Tanaka N,Kodama MInduction of apoptosis in human esophageal cancer cells by sequential transfer of the wild-type p53 and E2F-1 genes: involvement of p53 accumulation via ARF-mediated MDM2 down-regulation. Clin Cancer Res. 6(7):2851-9, 2000.
Henderson YC, Breau RL, Liu TJ, Clayman GL. Telomerase activity in head and neck tumors after introduction of wild-type p53, p21, p16, and E2F-1 genes by means of recombinant adenovirus. Head and Neck. 22(4):347-54, 2000.
Atienza C Jr, Elliott MJ, Dong YB, Yang HL, Stilwell A, Liu TJ, McMasters KM. Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors. Int J Mol Med. 6(1):55-63, 2000.
Glass TL, Liu TJ, Yung WK. Inhibition of cell growth in human glioblastoma cell lines by farnesyltransferase inhibitor SCH66336. Neuro-oncol 2(3):151-8, 2000.
Shelat HS, Liu TJ, Hickman-Bick DL, Barnhart MK, Vida T, Dillard PM, Willerson JT, Zoldhelyi P. Growth suppression of human coronary vascular smooth muscle cells by gene transfer of the transcription factor E2F-1. Circulation 103(3):407-14, 2001.
Fueyo J, Gomez-Manzano C, Liu TJ, Yung WK. Delivery of cell cycle genes to block astrocytoma growth. J Neurooncol 51(3):277-87, 2001.
Mitlianga PG, Kyritsis AP, Gomez-Manzano C, Lemoine MG, Hu M, Liu TJ, Yung WK, Fueyo J. Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells. Int J Oncol 18(2):343-7, 2001.
Cerrato JA, Yung WK, Liu TJ.. Introduction of mutant p53 into a wild-type p53- expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis. Neuro-oncol 3(2):113-22, 2001.
Im SA, Kim JS, Gomez-Manzano C, Fueyo J, Liu TJ, Cho MS, Seong CM, Lee SN, Hong YK, Yung WK. Inhibition of breast cancer growth in vivo by antiangiogenesis gene therapy with adenovirus-mediated antisense-VEGF. Br J Cancer 84(9):1252-7, 2001.
Gomez-Manzano C, Lemoine MG, Hu M, He J, Mitlianga P, Liu TJ, Yung AW, Fueyo J, Groves MD.Adenovirally-mediated transfer of E2F-1 potentiates chemosensitivity of human glioma cells to temozolomide and BCNU. Int J Oncol 19(2):359-65, 2001.
Gomez-Manzano C, Mitlianga P, Fueyo J, Lee HY, Hu M, Spurgers KB, Glass TL, Koul D, Liu TJ, McDonnell TJ, Yung WK.Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2. Cancer Res 61(18):6693-7, 2001.
Ikeda J, Tada M, Ishii N, Saya H, Tsuchiya K, Okaichi K, Mishima K, Sawamura Y, Fulci G, Liu TJ, Van Meir EG. Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis. Int J Cancer 94(1):35-43, 2001.
Shono T, Tofilon PJ, Schaefer TS, Parikh D, Liu TJ, Lang FF. Apoptosis Induced by Adenovirus-mediated p53 Gene Transfer in Human Glioma Correlates with Site-specific Phosphorylation. Cancer Res 62(4):1069-76, 2002.
Volpert O, Luo W, Liu TJ, Estrera VT, Logothetis C, Lin SH. Inhibition of prostate tumor angiogenesis by the tumor suppressor CEACAM1. J Biol Chem 277(38):35696- 702, 2002.
Sheng X, Koul D, Liu JL, Liu TJ, Yung WK. Promoter analysis of tumor suppressor gene PTEN: identification of minimum promoter region. Biochem. Biophys Res Commun. 292(2):422-6, March 2002.
Ghosh AK, Majumder M, Steele R, Liu TJ, Ray RB. MBP-1 mediated apoptosis involves cytochrome C release from mitochondria. Oncogene, 21(18):2775-84, April 2002.
Koul D, Shen R, Garyali A, Ke LD, Liu TJ, Yung WK. MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer. Int J Oncol. 21(3):469-75, September 2002.
Gomez-Manzano C, Fueyo J, Jiang H, Glass TL, Lee HY, Hu M, Liu JL, Jasti SL, Liu TJ, Conrad CA, Yung WK. Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol. 53(1):109-17, January 2003.
Yan DH, Abramian A, Li Z, Ding Y, Wen Y, Liu TJ, Hunt K. P202, an interferon- inducible protein, inhibits E2F1-mediated apoptosis in prostate cancer cells. Biochem Biophys Res Commun. 303(1):219-22, March 2003.
Jiang H, Conrad C, Fueyo J, Gomez-Manzano C, Liu TJ. Oncolytic adenoviruses for malignant glioma therapy. Front Biosci. 8:D577-88, May 2003.
Fueyo J, Alemany R, Gomez-Manzano C, Fuller GN, Khan A, Conrad CA, Liu TJ, Jiang H, LeMoine MG, Suzuki K, Sawaya R, Curiel DT, Yung WK, Lang FF. Preclinical characterization of the antiglioma activity of a tropism-ehanced adenovirus targeted to the retinoblastoma pathway. J Natl Cancer Inst. 95(9):652-60, May 2003.
Lee AW, Li JH, Shi W, Li A, Ng E, Liu TJ, Klamut HJ, Liu FF. P16 gene therapy: A potentially efficacious modality for nasopharyngeal carcinoma. Mol Cancer Ther. 2(10):961-9, October 2003.
Julie A.Cerrato, Tahira Khan, Dimpy Koul, Fred F. Lang, W.K. Alfred Yung, and Liu TJ. Differential Activation of the Fas/CD95 Pathway by Ad-p53 in Human Gliomas. Int J Oncol. 24(2):409-417, Feb. 2004.
Gomez-Manzano C, Balague C, Alemany R, LeMoine MG, Mitlianga P, Jiang H, Khan A, Alonso M, Lang FF, Conrad CA, Liu TJ, Beke BN, Yung WK, Fueyo J. A novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene, 23(10):1821- 8, March 2004.
Anna Aihua Li, Emily Ng , Wei Shi , Andrew Lee , Marie Chia , Ta-Jen Liu, Dolly Huang , Brian O'Sullivan , Pat Gullane , Fei-Fei Liu Potential efficacy of p16 gene therapy for EBV-positive nasopharyngeal carcinoma. Int J of Cancer Volume 110, Issue 3 , Pages 452 – 458
Yi-Hong Zhou, Xiaosong Wu, Fang Tan, Yue-Xi Shi, Tricia Glass, T. J. Liu, Kyle Wathen, Kenneth R. Hess, Joy Gumin, Frederick Lang and W. K. Alfred. PAX6 suppresses growth of human glioblastoma cells. J Neurooncol. 2005 Feb;71(3):223-9..
John F. de Groot, Ta Jen Liu, Gregory Fuller and W.K. Alfred Yung. The Excitatory Amino Acid Transporter-2 Induces Apoptosis and Decreases Glioma Growth In vitro and In vivo. Cancer Research 65, 1934-1940, March 1, 2005.
Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, Mills GB, Yung WK. Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma. Mol Cancer Ther. 2005 Nov;4(11):1681-8.
Ok-Hee Lee, Jing Xu, Juan Fueyo, Gregory N. Fuller, Kenneth D. Aldape, Marta M. Alonso, Yuji Piao, Ta-Jen Liu, Frederick F. Lang, B. Nebiyou Bekele and Candelaria Gomez-Manzano. Expression of the Receptor Tyrosine Kinase Tie2 in Neoplastic Glial Cells Is Associated with Integrin ß1-Dependent Adhesion to the Extracellular Matrix. Mol Cancer Research 4:915-926 (2006).
Yan Xia, Ji Wang, Ta-Jen Liu, W.K. Alfred Yung, Tony Hunter, and Zhimin Lu. c-Jun Downregulation by HDAC3-Dependent Transcriptional Repression Promotes Osmotic Stress-Induced Cell Apoptosis. Molecular Cell, Vol 25, 219-232, 26 January 2007.
Morris D. Groves ,Vinay K. Puduvalli,Susan M. Chang,Charles A. Conrad, Mark R. Gilbert, Ivo W. Tremont-Lukats, Ta-Jen Liu, Pamela Peterson,David Schiff, Timothy F. Cloughesy,Patrick Y. Wen,Harry Greenberg,Lauren E. Abrey, Lisa M. DeAngelis, Kenneth R. Hess, Kathleen R. Lamborn, Michael D. Prados and W. K. Alfred Yung. A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme. J. Neurooncology 81(3):271-7, Feb 2007
Puchades M, Nilsson CL, Emmett MR, Aldape KD, Ji Y, Lang FF, Liu TJ, Conrad CA. Proteomic investigation of glioblastoma cell lines treated with wild-type p53 and cytotoxic chemotherapy demonstrates an association between galectin-1 and p53 expression. J Proteome Res. 6(2):869-75, Feb 2007.
Ta-Jen Liu, Tiffany Lafortune, Ningyi Tiao, Jennifer Edge, Verlene Henry, John deGroot, and WK Alfred Yung. Inhibition of both Focal Adhesion Kinase (FAK) and Insulin-like Growth Factor-1 Receptor (IGF-IR) kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther 6, 1357-1367, April 2007.
E L Kreimann, F C Morales, J de Orbeta-Cruz, Y Takahashi, H Adam, T-J Liu, P D McCrea, and M-M Georgescu. Cortical stabilization of β-catenin contributes to NHERF1/EBP50 tumor suppressor function. Oncogene. 26(36): 5290-9, Aug 2007.
Lee OH, Xu J, Fueyo J, Alonso MM, Liu D, Martin V, Jiang H, Piao Y, Liu TJ Gomez-Manzano C. Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1alpha levels in gliomas. Oncogene. 2008, 27(9): 1310- 1314.
Nakamizo A, Amano T, Zhang W, Zhang XQ, Ramdas L, Liu TJ, Bekele BN, Shono T, Sasaki T, Benedict WF, Sawaya R, Lang FF. Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. Neuro Oncol. 2008 , Jun;10(3):275-91.
Morris D. Groves, Kenneth R. Hess, Vinay K Puduvalli, Howard Colman, Charles A Conrad, Mark R Gilbert, Jeffrey Weinberg, Massimo Cristofanilli, WK Alfred Yung, Ta- Jen Liu. Biomarkers of Disease: Cerebrospinal fluid Vascular Endothelial Growth factor (VEGF) and Stromal cell derived factor (SDF)-1 levels in patients with neoplastic meningitis (NM) due to breast cancer, lung cancer and melanoma. J. Neurooncol. 2009, 94(2): 229-234.
Liu TJ, Koul D, LaFortune T, Tiao N, Shen RJ, Maira SM, Garcia-Echevrria C, Yung WK. NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas. Mol Cancer Ther 8:2204-2210, Aug 2009.
Kim YW, Liu TJ, Koul D, Tiao N, Feroze AH, Wang J, Powis G, Yung WK. Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM. Neuro Oncol 2011, Apr;13(4):367-75.