Vice President John S. Kuo
| Current Positions |
|---|
| Vice President, China Medical University (TAIWAN) |
| Chair Professor, China Medical University (TAIWAN) |
| Chair Professor, Asia University(TAIWAN) |
| Yu Shan Scholar, Ministry of Education (TAIWAN) |
| Professor, The University of Texas at Austin (USA) |
| Period | Education |
|---|---|
| 09/89 - 06/98 | M.D., Harvard Medical School (Harvard-MIT Division of Health Sciences and Technology), Boston, MA |
| 09/92 - 06/98 | Ph.D., Massachusetts Institute of Technology, Cambridge, MA |
| 09/85 - 06/89 | A.B., Biology (summa cum laude), Harvard University, Cambridge, MA |
| 09/82 - 06/85 | H.S. diploma (Regents Honors), The Bronx H.S. of Science, Bronx, NY |
| Period | Clinical and Postdoctoral Training |
|---|---|
| 07/04 - 06/05 | Chief Resident, Neurological Surgery USC-Affiliated Hospitals, Los Angeles, California |
| 07/03 - 06/04 | ABTA Postdoctoral Research Fellow Division of Neurosurgery, The Hospital for Sick Children Arthur and Sonia Labatt Brain Tumour Research Centre University of Toronto, Toronto, Ontario, Canada |
| 01/03 - 06/03 | Fellow, Stereotactic Radiosurgery USC University Hospital, USC Norris Comprehensive Cancer Center, Los Angeles, California |
| 07/99 - 06/04 | Resident, Neurological Surgery USC-Affiliated Hospitals, Los Angeles, California |
| 06/98 - 06/99 | Intern, Neurological Surgery USC-Affiliated Hospitals, Los Angeles, California |
| Period | Past Academic and Leadership Appointments |
|---|---|
| 04/18 – 08/21 | Inaugural Chair, Department of Neurosurgery Dell Medical School, The University of Texas at Austin, Austin, TX |
| 04/18 – 08/21 | Professor with Tenure Department of Neurosurgery Dell Medical School, The University of Texas at Austin, Austin, TX |
| 04/18 – 08/21 | Surgical Director Mulva Clinic for the Neurosciences The University of Texas at Austin, Austin, TX |
| 04/18 – 08/21 | Faculty, Institute for Neuroscience, The University of Texas at Austin, Austin, TX |
| 09/18 – 08/21 | Faculty, Institute for Molecular and Cellular Biology, The University of Texas at Austin, Austin, TX |
| 12/18 – 08/21 | Professor (secondary appointment) Dept. of Oncology Dell Medical School, The University of Texas at Austin, Austin, TX |
| 04/19 – 08/21 | Director of Neuro-Oncology Program, LIVESTRONG Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX |
| 07/17 – 04/18 | Professor of Neurological Surgery and Human Oncology with Tenure University of Wisconsin School of Medicine and Public Health, Madison, WI |
| 07/15 – 04/18 | Faculty, Center for Training in Pharmacology and Drug Development and Molecular Cellular Pharmacology, University of Wisconsin, Madison, WI |
| 08/14 – 08/19 | Yeoh Ghim Seng Visiting Professorship in Surgery, Dept. of Surgery Yong Loo Lin School of Medicine, National University of Singapore, Singapore |
| 07/13 – 07/17 | Associate Professor (courtesy appointment), Dept. of Human Oncology University of Wisconsin School of Medicine and Public Health, Madison WI |
| 07/13 – 07/17 | Associate Professor of Neurological Surgery and Human Oncology with Tenure University of Wisconsin School of Medicine and Public Health, Madison, WI |
| 07/12 – 04/18 | Investigator, Institute for Clinical and Translational Research University of Wisconsin School of Medicine and Public Health, Madison, WI |
| 07/10 – 04/18 | Faculty, Neuroscience/Public Policy graduate training program University of Wisconsin, Madison, WI |
| 07/09 – 04/18 | Faculty, Cellular and Molecular Pathology graduate training program University of Wisconsin, Madison, WI |
| 01/06 – 04/18 | Faculty, MD-PhD Training program, University of Wisconsin, Madison, WI |
| 01/06 – 04/18 | Faculty, Neuroscience graduate training program University of Wisconsin, Madison, WI |
| 01/06 – 04/18 | Faculty, Cell and Molecular Biology graduate training program University of Wisconsin, Madison, WI |
| 01/06 – 04/18 | Member, Center for Stem Cell and Regenerative Medicine University of Wisconsin, Madison, WI |
| 01/06 – 04/18 | Comprehensive Brain Tumor Program Director, University of Wisconsin Carbone Cancer Center, Madison, WI |
| 07/08 – 07/13 | Assistant Professor (courtesy appointment), Dept. of Human Oncology University of Wisconsin School of Medicine and Public Health, Madison WI |
| 10/05 – 07/13 | Assistant Professor of Neurological Surgery (Tenure track) University of Wisconsin School of Medicine and Public Health, Madison, WI |
| 07/04 – 07/05 | Clinical Instructor and Resident Supervisor Dept. of Neurological Surgery, USC-Affiliated Hospitals, Los Angeles, CA |
| Period | Awards and Honors |
|---|---|
| 2021-2024 | Yu Shan Scholar, Ministry of Education, TAIWAN |
| 2012-2022 | America’s Top Doctors (Neurological Surgery), Castle Connolly |
| 2020-2022 | Top Doctors, Austin Monthly |
| 2020-2022 | America’s Most Honored Doctors |
| 2017 | American Academy of Neurological Surgeons (elected) |
| 2017 | Castle Connolly Top Doctors for 5 Consecutive Years |
| 2016-2019 | America’s Top Honored Professionals, Top 1% |
| 2015, 2017 | High Demand Faculty Award, School of Medicine and Public Health, University of Wisconsin |
| 2015 | Preuss Award, for the best basic science research AANS/CNS Joint Tumor Section |
| 2015 | Society of University Surgeons (elected) |
| 2014-2019 | Yeoh Ghim Seng Visiting Professorship in Surgery National University of Singapore |
| 2007, 2009, 2010, 2012, 2013 | Citations for Excellence in Medical Student Teaching School of Medicine and Public Health, University of Wisconsin |
| 2014 | Wisconsin’s Top 10 Neurological Surgery Specialists |
| 2013 | Vitals Patients’ Choice Awards – One of Wisconsin’s Favorite Physicians |
| 2012-2015 | Top Compassionate Doctors, Neurological Surgery |
| 2011, 2012 | America’s Top Surgeons, Consumer’s Research Council of America |
| 2008-2017 | Headrush Brain Tumor Research Professorship award, first recipient |
| 2008 | Young Clinician Investigator Award Neurosurgery Research and Education Foundation, American Association of Neurological Surgeons |
| 2003 | Neurosurgery Research and Education Foundation Research Fellowship American Association of Neurological Surgeons |
| 2003 | American Brain Tumor Association Research Fellowship |
| 1998 | Sigma Xi - The Scientific Research Society of North America |
| 1994, 1995 | MIT Dept. of Biology (highest rated teaching assistant) |
| 1994 | MIT Yaichi Ayukawa Japan Travel Prize |
| 1989 | Phi Beta Kappa |
| 1985-1988 | Tutor Award Supervisor, Harvard University |
| 1987 | Francis M. Weld Memorial National Scholarship |
| 1987 | William Burden Memorial National Scholarship |
| 1986 | Frank Tarr Memorial National Scholarship |
| 1986-1989 | John Harvard Scholarship |
| 1985-1989 | Dean’s Lists |
| 1985-1989 | Harvard National Scholar |
| 1985-1989 | National Merit Scholar |
| 1985 | Harvard College Scholarship |
| 1985 | Admitted with Advanced Sophomore Standing, Harvard College |
| 1985 | Fifth Place – National Westinghouse Science Talent Search |
| 1985 | International Chemistry Olympiad Nominee |
| 1985 | American Academy of Achievements Citation |
| 1985 | Governor’s Citation for Academic Excellence |
| 1985 | Bausch and Lomb Science Prize |
| 1985 | Biology Research Prize |
| 1985 | Arista – National Honor Society |
| 1984 | Rensselaer Medal for Math and Science |
| No. | Editorial Boards |
|---|---|
| 1 | Coordinating Editor, NeuroMolecular Medicine |
| 2 | Tumor Section Editor, Operative Neurosurgery |
| 3 | Tumor Section Editor, World Neurosurgery |
| 4 | Associate Editor, Frontiers in Neuro-Oncology and Neurosurgical Oncology |
| 5 | Editorial Board, Nature Scientific Reports |
| No. | Peer-reviewed publications |
|---|---|
| 1 | Cheng SW, Chang CW, Chang WJ, Wang HW, Liang CS, Kishimoto T, Chang JPC, Kuo JS, Su KP “The now and future of ChatGPT and GPT in psychiatry.” Psychiatry and Clinical Neurosciences (published online August 23, 2023). PMID: 37612880. *Featured paper |
| 2 | Tseng PT, Zeng BY, Zeng BS, Liao YC, Stubbs B, Kuo JS, Sun CK, Cheng YS, Chen YW, Chen TY, Tu YK, Lin PY, Hsu CW, Li DJ, Liang CS, Suen MW, Wu YC, Shiue YL, Su KP “High dose omega-3 polyunsaturated fatty acid supplement in sarcopenia nutritional management: a systemic review and network meta-analysis of randomized controlled trials.” Ageing Research Reviews 90: 102014 (published online July 11, 2023). PMID: 37442370. |
| 3 | Tseng PT, Zeng BS, Suen MW, Wu YC, Correll CU, Zeng BY, Kuo JS, Chen YW, Chen TY, Tu YK, Lin PY, Carvalho AF, Stubbs B, Li DJ, Liang CS, Hsu CW, Sun CK, Cheng YS, Yeh PY, Wu MK, Shiue YL, Su KP “Efficacy and acceptability of anti-inflammatory eicosapentaenoic acid for cognitive function in Alzheimer’s dementia: a network meta-analysis of randomized, placebo-controlled trials with omega-3 fatty acids and FDA-approved pharmacotherapy.” Brain Behavior & Immunity 111:352-364 (published May 6, 2023). PMID: 37150266. |
| 4 | Lin CY, Chou LS, Wu YH, Kuo JS, Mehta MP, Shiau AC, Liang JA, Hsu SM, Wang TH “Developing an AI-assisted planning pipeline for hippocampal avoidance whole brain radiotherapy.” Radiotherapy & Oncology 181: 109528 (published April 1, 2023). PMID: 36773628. |
| 5 | Zhang RR, Choi C, Brunnquell CL, Hernandez R, Pinchuk AN, Grudzinski JG, Clark PA, McMillan AB, Audhya A, Jeffrey J, Kuo JS, Weichert JP “Next generation cancer magnetic resonance imaging with tumor-targeted alkylphosphocholine metal analogs.” Investigative Radiology 57 (10): 655-663 (published online June 22, 2022). PMID: 36069439. PMCID: PMC9469686. |
| 6 | Grudzinski JJ, Hall LT, Cho S, Liu G, Traynor A, Lee MH, Longino M, Pinchuk A, Jaskowiak C, Bednarz B, Weichert J, Kuo JS “Clinical imaging and dosimetry of a pan-cancer targeting alkylphosphocholine analog, 124I-NM404.” Radiation 2: 215-227 (published online May 17, 2022). |
| 7 | Umlauf BJ, Kuo JS, Shusta EV “Identification of brain ECM binding variable lymphocyte receptors using yeast surface display.” Methods in Molecular Biology 2491: 235-248 (published online April 29, 2022). PMID: 35482194. |
| 8 | Iyer V and Kuo JS “Emerging frontiers of therapeutic strategies for brain tumors.” NeuroMolecular Medicine 24 (1): 1-2 (published online January 7, 2022). PMID: 34993732. |
| 9 | Wesley UV, Sutton I, Clark PA, Cunningham K, Larrain C, Kuo JS, Dempsey RJ “Enhanced expression of pentraxin-3 in glioblastoma cells correlates with increased invasion and IL8-VEGF signaling axis.” Brain Research 1776: 147752 (published online December 11, 2021). PMID:34906547. |
| 10 | Kukreja L, Li C, Ezhilan S, Iyer V, Kuo JS “Emerging epigenetic therapies for brain tumors.” NeuroMolecular Medicine 24 (1): 41-49 (published online October 22, 2021). PMID: 34677796. |
| 11 | Riley SP, Chu DY, Nair VA, Baskaya MK, Kuo JS, Meyerand ME, Prabhakaran V “Characterizing the relationship between lesion-activation distance using fMRI and verbal measures in brain tumor patients.” Interdisciplinary Neurosurgery 27: 101391 (published online September 29, 2021). PMID: 34950570. |
| 12 | Chen KT, Chai WY, Lin YJ, Lin CJ, Chen PY, Tsai HC, Huang CY, Kuo JS, Liu HL, Wei KC “Neuronavigation-guided focused ultrasound for transcranial blood-brain-barrier opening and immunostimulation in brain tumors.” Science Advances 7 (6): eabd0772 (published online February 5, 2021). PMID: 33547073. |
| 13 | Ouellette JN, Drifka CR, Pointer KB, Liu Y, Lieberthal TJ, Kao WJ, Kuo JS, Loeffler AG, Eliceiri K “Navigating the collagen jungle: the biomedical potential of fiber organization in cancer.” Special issue on “Biomedical applications of collagen.” Bioengineering 8 (2): 17 (published January 21, 2021). DOI: 10.3390/bioengineering8020017. *Chosen for the cover. PMID: 33494220. PMCID: PMC7909776. |
| 14 | Surapaneni A, Kuo JS, Wang M, Ashour R “Epidermoid cyst in a patient with Alagille syndrome: Coincidence or connection? Case report and literature review.” Surgical Neurology International 11: 432 (published online December 11, 2020). PMID: 33365194. PMCID: PMC7749940. |
| 15 | Alrfaei BM, Clark PA, Vemuganti R, Kuo JS* “MicroRNA miR-100 decreases glioblastoma growth by targeting SMARCA5 and ErbB3 in tumor-initiating cells.” Technology Cancer Research & Treatment 19: 1-13 (published online August 28, 2020). PMID: 32945237. PMCID: PMC7502994. |
| 16 | Song HW, Foreman KL, Gastfriend BD, Kuo JS, Palecek SP, Shusta EV, “Transcriptomic comparison of human and mouse brain microvessels.” Scientific Reports 10 (1) :12358. doi: 10.1038/s41598-020-69096-7 (published online July 23, 2020). PMID: 32704093. PMCID: PMC7378255. |
| 17 | Clark PA, Sriramaneni RN, Wonjon J, Jagodinsky JC, Jaquish A, Anderson B, Lubin JA, Bates AM, Heinze C, Guy EI, Kler J, Klar KA, Carlson P, Kuo JS, Morris ZS “In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases.” Journal for Immunotherapy of Cancer 2020;8: e000809. doi:10.1136/jitc-2020-000809 (published online July 19, 2020). PMID: 32690669. PMCID: PMC7371368. |
| 18 | Chen KT, Lin YJ, Chai WY, Lin CJ, Chen PY, Huang CY, Kuo JS, Liu HL, Wei KC “Neuronavigation-guided focused ultrasound (NaviFUS) for transcranial blood-brain barrier opening in recurrent glioblastoma patients: clinical trial protocol.” Annals of Translational Medicine 8 (11): 673. (published May 15, 2020). PMID: 32617293. PMCID: PMC7327352. |
| 19 | Alhajala HS, Markley JL, Kim JH, Al-Gizawiy MM, Schmainda KM, Kuo JS, Chitambar CR “The cytotoxicity of gallium maltolate in glioblastoma cells is enhanced by metformin through combined action on mitochondrial complex 1.” Oncotarget 11 (17): 1531-1544 (published online April 28, 2020) PMID: 32391122. PMCID: PMC7197450. |
| 20 | Schroeder AB, Pointer KB, Clark PA, Datta R, Kuo JS, Eliceiri KW “Metabolic mapping of glioblastoma stem cells reveals NADH fluxes associated with glioblastoma phenotype and survival.” Journal of Biomedical Optics 25 (3), 036502 (Published online March 25, 2020). http://dx.doi.org/10.1117/1.JBO.25.3.036502. PMID: 32216192. PMCID: PMC7093735. |
| 21 | Walker BJ, Cox BL, Cikla U, De Bellefon GM, Rankouhi B, Steiner LJ, Mahadumrongkul P, Petry G, Thevamaran M, Swader R, Kuo JS, Suresh K, Thoma D, Eliceiri KW “An investigation into the challenges of using metal additive manufacturing for the production of patient specific aneurysm clips.” Journal of Medical Devices 13 (3): 031009-1-10 (published online July 15, 2019). |
| 22 | Hall LT, Titz B, Baidya N, van der Kolk AG, Robins HI, Bednarz BP, Otto M, Perlman SB, Weichert JP, Kuo JS “124I-CLR1404 PET/CT in high grade primary and metastatic brain tumors.” Molecular Imaging and Biology (published online June 10, 2019). PMID: 31183841. |
| 23 | Umlauf BJ, Clark PA, Lajoie JM, Georgieva JV, Bremner S, Herrin BR, Kuo JS*, Shusta EV* “Identification and characterization of variable lymphocyte receptor antibodies that target pathologically exposed brain extracellular matrix.” Science Advances 5 (5): eaau4245 (published online May 15, 2019) PMID: 31106264. PMCID: PMC6520025. |
| 24 | Zhang RR, Grudzinski JJ, Mehta TI, Burnette RR, Hernandez R, Clark PA, Lubin JA, Pinchuk AN, Jeffrey J, Longino M, Kuo JS*, Weichert JP* “In silico docking of alkylphosphocholine analogs to human serum albumin predict partitioning and pharmacokinetics.” (co-senior authors) Molecular Pharmaceutics 16 (8): 3350-3360 (published online May 13, 2019). PMID: 31082240. PMCID: PMC6989153. |
| 25 | Nahed BV, Alvarez-Breckenridge C, Brastianos PK, Shih H, Sloan A, Ammirati M, Kuo JS, Ryken TC, Kalkanis SN, Olson JJ “Congress of Neurological Surgeons systematic review and evidence-based practice guideline on the role of surgery in the management of adults with metastatic brain tumors.” Neurosurgery 84 (3): E152-155 (published online January 9, 2019) PMID: 30629227. |
| 26 | Ryken TC, Kuo JS, Prabhu RS, Sherman JH, Kalkanis SN, Olson JJ “Congress of Neurological Surgeons systematic review and evidence-based practice guideline on the role of steroids in the management of adults with metastatic brain tumors.” Neurosurgery 84 (3): E189-191 (published online January 9, 2019) PMID: 30629207. |
| 27 | Teo KA, Yang L, Leow R, Lwin S, Kuo JS “Minimally-invasive approach to posterior fossa decompression: Initial experience in adult Chiari type I malformation patients.” Journal of Clinical Neuroscience 56: 90-94 (published online July 4, 2018) PMID: 30318076. |
| 28 | Goldstein AM, Keswani SG, Gosain A, Morowitz M, Kuo JS, Levine M, Blair AB, Ahuja N, Hackam D “A roadmap for aspiring surgeon-scientists in today’s healthcare environment.” Annals of Surgery (published online June 28, 2018). PMID: 29958227. PMCID: PMC6298819. |
| 29 | Vergun S, Suhonen JI, Nair VA, Kuo JS, Baskaya MK, Garcia-Ramos C, Meyerand EE, Prabhakaran V “Predicting primary outcomes of brain tumor patients with advanced neuroimaging MRI measures.” Interdisciplinary Neurosurgery 13: 109-118 (published online April 22, 2018). |
| 30 | Chitambar CR, Al-Gizawiy MM, Alhajala HS, Pechman KR, Wereley JP, Wujek R, Clark PA, Kuo JS, Antholine WE, Schmainda KM “Gallium maltolate disrupts tumor iron metabolism and retards the growth of glioblastoma by inhibiting mitochondrial function and ribonucleotide reductase.” Molecular Cancer Therapeutics (published online March 28, 2018). PMID: 29592883. |
| 31 | Vysotski S, Madura C, Swan B, Holdsworth R, Lin Y, Munoz Del Rio A, Wood J, Kundu B, Penwarden A, Voss J, Gallagher T, Nair VA, Field A, Garcia-Ramos C, Meyerand ME, Baskaya M, Prabhakaran V*, Kuo JS* “Preoperative fMRI associated with decreased mortality and morbidity in brain tumor patients.” Interdisciplinary Neurosurgery 13: 40-45 (published online February 14, 2018). PMID: 31341789. PMCID: PMC6653633. |
| 32 | Hsu SPC*, Kuo JS*, Chiang HC, Wang HE, Wang YS, Huang CC, Huang YC, Chi MS, Mehta MP, Chi KH “"Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells." (* equal contribution) Oncotarget 9 (6): 6883-6896 (published online January 3, 2018). PMID: 29467937. PMCID: PMC5805523. |
| 33 | Zorniak M, Clark PA, Umlauf BJ, Cho Y, Shusta EV*, Kuo JS* “Yeast display biopanning identifies human antibodies targeting glioblastoma stem-like cells.” Scientific Reports 7: 15840 (published online November 20, 2017). PMID: 29158489. PMCID: PMC5696472. * Top 100 in Oncology collection for 2017 in Scientific Reports after only 1 month. |
| 34 | Doan NB, Alhajala H, Al-Gizawiy MM, Mueller WM, Rand SD, Connelly JM, Cochran EJ, Chitambar CR, Clark PA, Kuo JS, Schmainda KM, Mirza SP “Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency.” Oncotarget 8 (68): 112662-112674 (published online November 7, 2017). PMID: 29348854. PMCID: PMC5762539. |
| 35 | Hall LT, Titz B, Robins HI, Howard SP, Bednarz BP, Perlman SB, Weichert JP, Kuo JS, “PET/CT imaging of the diapeutic alkylphosphocholine analog 124I-CLR1404 in high and low-grade brain tumors.” American Journal of Nuclear Medicine and Molecular Imaging 7 (4): 157-166 (September 1, 2017). PMID: 28913154. PMCID: PMC5596318. |
| 36 | Kalluri HS, Kuo JS, Dempsey RJ “Chronic D609 interferes with cell cycle and targets Olig2 expression in glioma stem like cells.” European Journal of Pharmacology (published online August 10, 2017). PMID: 28802717. |
| 37 | Besemer AE, Titz B, Grudzinski JJ, Weichert JP, Kuo JS, Robins HI, Hall LT, Bednarz BP “Impact of PET and MRI threshold-based tumor volume segmentation on patient-specific targeted radionuclide therapy patient-specific dosimetry using CLR1404.” Physics in Medicine & Biology 62 (15): 6008-6025 (July 6, 2017). PMID: 28682793. PMCID: PMC6771923. |
| 38 | Liu C, Clark PA, Kuo JS, Kalejta R “Human cytomegalovirus-infected glioblastoma cells display stem cell-like phenotypes.” mSphere 2 (3): e00137-17 (published online June 21, 2017). PMID: 28656174. PMCID: PMC5480031. |
| 39 | Meyer EJ, Gaggl W, Gilloon B, Swan B, Greenstein M, Voss J, Hussain N, Holdsworth RL, Nair VA, Meyerand ME, Kuo JS, Baskaya MK, Field AS, Prabhakaran V “The impact of intracranial tumor proximity to white matter tracts on morbidity and mortality: a retrospective DTI study.” Neurosurgery 80 (2): 193-200 (February 1, 2017). PMID: 28173590. |
| 40 | Zhang RR, Schroeder AB, Grudzinski JJ, Rosenthal EL, Warram JM, Pinchuk AN, Eliceiri KW, Kuo JS*, Weichert JP* “Beyond the margins: Real time detection of cancer with targeted fluorophores.” Nature Reviews Clinical Oncology 14 (6): 347-364 (published online January 17, 2017). PMID: 28094261. |
| 41 | Robins HI, Kuo JS, Deming DA “Tumor treating field therapy in non-MGMT-methylated newly diagnosed glioblastoma: Is there a role for temozolomide?” Cancer Cell and Microenvironment 4: e1502 (2017). |
| 42 | Clark PA, Gaal JT, Pasch CA, Deming DA*, Kuo JS*, Robins HI* “The effects of Tumor Treating Fields and temozolomide in MGMT-expressing and non-expressing patient-derived glioblastoma stem-like cells.” Journal of Clinical Neuroscience 36: 120-124 (published online November 16, 2016) PMID: 27865821. PMCID: PMC5215614. |
| 43 | Kalluri HS, Kuo JS, Dempsey RJ “Effect of D609 on the expression of GADD45 protein expression: Potential inhibitory role in the growth of glioblastoma cancer stem like cells.” European Journal of Pharmacology 791: 510-517 (published online September 20, 2016) PMID: 27658347. |
| 44 | Keswani SG, Moles CM, Morowitz M, Zeh H, Kuo JS, Levine M, Cheng LS, Hackam DJ, Ahuja N, Goldstein AM “The future of basic science in academic surgery: Identifying barriers to success for surgeon-scientists.” Annals of Surgery 265 (6): 1053-1059 (published online September 16, 2016). PMID: 27643928. *highlighted with commentaries in Annals of Surgery, Nature. |
| 45 | Kuo JS*, Barkhoudarian G, Farrell CJ, Bodach ME, Tumialan LM, Oyesiku NM, Litvack Z, Zada G, Patil CG, Aghi MK “Guidelines: Congress of Neurological Surgeons systematic review and evidence-based guideline on surgical techniques and technologies for the management of patients with nonfunctioning pituitary adenomas.” Neurosurgery 79 (4): E536-538 (published online September 19, 2016) PMID: 27635962. |
| 46 | Aghi MK, Chen CC, Fleseriu M, Newman SA, Lucas JW, Kuo JS, Barkhoudarian G, Farrell CJ, Sheehan J Ziu M, Dunn IF “Congress of Neurological Surgeons systematic review and evidence-based guidelines on the management of patients with nonfunctioning pituitary adenomas: Executive summary.” Neurosurgery 79 (4): 521-523 (published online September 19, 2016) PMID: 27635956. |
| 47 | Pointer KB, Clark PA, Eliceiri KW, Robertson G*, Kuo JS* “Administration of non-torsadogenic human Ether-à-go-go Related Gene (hERG) inhibitors is associated with better survival for high hERG-expressing glioblastoma patients.” Clinical Cancer Research 23 (1): 73-80 (published online September 15, 2016) *highlighted article, also paired with a ‘CCR Translations’ commentary. PMID: 27635088. |
| 48 | Zhang RR, Swanson KI, Hall LT, Weichert JP, Kuo JS “Diapeutic cancer-targeting alkylphosphocholine analogs may advance management of brain malignancies.” CNS Oncology 5 (4): 223-231 (published online September 12, 2016) PMID: 27616199. PMCID: PMC5514628. |
| 49 | Pointer KB, Clark PA, Salamat MS, Eliceiri KW, Kuo JS* “Association of collagen architecture with glioblastoma survival.” Journal of Neurosurgery 126 (6): 1812-1821 (published online September 2, 2016). PMID: 27588592. PMCID: PMC5386834. |
| 50 | Gaal J, Stenerson, M, Kuo JS* “The enduring legacy of pioneering neuroscientist Dr. Jerzy Edwin Rose.” Journal of Clinical Neuroscience 33: 69-72 (published online August 11, 2016) PMID: 27523584. |
| 51 | Clark PA, Al-Ahmad AJ, Qian T, Zhang RR, Wilson HK, Weichert JP, Palecek SP, Kuo JS*, Shusta EV* “Analysis of cancer-targeting alkylphosphocholine analogs permeability characteristics using a human induced pluripotent stem cell blood brain barrier model.” Molecular Pharmaceutics 13 (9): 3341-9 (published online July 15, 2016). PMID 27421304. PMCID: PMC5014630. |
| 52 | Clark PA, Bhattacharya S, Elmayan A, Soesiawati RD, Thuro BA, Yan M, van Ginkel PR, Polans AS, Kuo JS* “Resveratrol targets glioblastoma and glioblastoma stem-like cells via widespread anti-tumorigenic mechanisms involving AKT and p53 activation.” Journal of Neurosurgery 126 (5): 1448-1460 (published online July 15, 2016). PMID: 27419830. PMCID: PMC5237623. |
| 53 | Zhu W, Carney KE, Pigott VM, Falgoust LM, Clark PA, Kuo JS, Sun D “Glioma-mediated microglia activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1.” Carcinogenesis 37 (9): 839-851 (published online June 9. 2016) PMID: 27287871. PMCID: PMC5008247. |
| 54 | Liu HL, Hsu PH, Lin CY, Huang CW, Chai WY, Chu PC, Huang CY, Chen PY, Yang LY, Kuo JS, Wei KC, “Focused ultrasound enhances CNS delivery of bevacizumab for malignant glioma treatment.” Radiology 281 (1): 99-108 (published online May 18, 2016) *highlighted with accompanying ‘Science to Practice’ commentary October 2016. PMID: 27192459. |
| 55 | De I, Steffen MD, Clark PA, Patros CJ, Sokn E, Bishop SM, Litscher S, Maklakova VI, Kuo JS, Rodriguez FJ, Collier LS “CSF1 over-expression promotes high grade glioma formation in vivo without impacting the polarization status of glioma associated microglia and macrophages.” Cancer Research 76 (9): 2552-2560 (published online March 24, 2016). PMID: 27013192. PMCID: PMC4873447. |
| 56 | Swanson KI, Nickele C, Kuo JS “Iatrogenic intracranial placement of nasopharyngeal airway after trauma.” British Journal of Neurosurgery 30 (4): 448-9 (published online January 13, 2016). PMID: 26760290. |
| 57 | Nadkarni TN, Andreoli MJ, Nair VA, Yin P, Young B, Kundu B, Pankratz J, Radtke A, Holdsworth R, Kuo JS, Field AS, Baskaya MK, Moritz CH, Meyerand E, Prabhakaran V “Usage of fMRI for pre-surgical planning in tumor and vascular lesion patients: task and statistical threshold effects on language lateralization.” NeuroImage: Clinical 7: 415-23 (published online December 24, 2014). PMID: 25685705. PMCID: PMC4310930. |
| 58 | Cong D, Zhu W, Kuo JS, Hu S, Sun D “Ion transporters in brain tumors.” Current Medicinal Chemistry 22 (10): 1171-81 (published online January 14, 2015). PMID: 25620102. PMCID: PMC4363268. |
| 59 | Swanson KI, Clark PA, Zhang RR, Kandela IK, Farhoud M, Weichert JP, Kuo JS “Fluorescent cancer-selective alkylphosphocholine analogs for intraoperative glioma detection.” Neurosurgery 76 (2): 115-24 (February 2015) *featured as High Impact Manuscript, chosen for the cover and a video abstract). PMID: 25549194. PMCID: PMC4343207. |
| 60 | Zorniak M, Clark PA, Kuo JS “Myelin-forming cell-specific cadherin-19 is a marker for minimally invasive glioblastoma stem-like cells.” Journal of Neurosurgery 122 (1): 69-77 (published online October 31, 2014). PMID: 25361488. PMCID: PMC4337891. |
| 61 | Lyon W, Mehta TI, Pointer K, Walden D, Elmayan A, Swanson KI, Kuo JS “Clinton Woolsey: Functional brain mapping pioneer.” Journal of Neurosurgery 121(4): 983-8 (published online August 8, 2014). PMID: 25105696. PMCID: PMC4354805. |
| 62 | Brower J, Clark PA, Lyon W, Kuo JS “MicroRNA in cancer: Glioblastoma and glioblastoma cancer stem cells.” Neurochemistry International 77: 68-77 (published online June 14, 2014). PMID: 24937770. PMCID: PMC4390175. |
| 63 | Weichert JP*, Clark PA, Kandela IK, Vaccaro AM, Clark W, Longino MA, Pinchuk AN, Farhoud M, Swanson KI, Floberg JM, Grudzinksi J, Titz B, Traynor AM, Chen HE, Hall LT, Pazoles CJ, Pickhardt PJ, Kuo JS* “Alkylphosphocholine analogs for broad spectrum cancer imaging and therapy.” (*Co-senior authors) Science Translational Medicine 6, 240ra75 (June 11, 2014). *Chosen for the cover, featured with podcast. PMID: 24920661. PMCID: PMC4336181. |
| 64 | Cong D, Zhu W, Shi Y, Pointer KB, Clark PA, Kuo JS, Hu S, Sun D “Up-regulation of NHE-1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+ extrusion, cell migration and survival.” Carcinogenesis 35 (9): 2014-24 (published online April 9, 2014). PMID: 24717311, PMCID: PMC4146414. |
| 65 | Pointer KB, Zorniak M, Clark PA, Alrfaei BM, Kuo JS “Glioblastoma cancer stem cells: Biomarker and therapeutic advances.” Neurochemistry International 71: 1-7 (published online March 19, 2014). *2nd most downloaded paper of January-June 2014. PMID: 24657832. PMCID: PMC4119816. |
| 66 | Zhu W, Begum G, Pointer K, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D “WNK1/OSR1/NKCC1 signaling pathway regulates glioma cell migration in the absence and presence of temozolomide.” Molecular Cancer 13 (1): 13-31 (published online February 20, 2014) PMID 24555568. PMCID: PMC3936893. |
| 67 | Alrfaei BM, Vemuganti R, Kuo JS “MicroRNA100 targets SMRT, reduces proliferation and improves survival in glioblastoma.” PLoS One 8 (11): e80865 (published online November 14, 2013) PMID 24244722. PMCID: PMC3828259. |
| 68 | Anderson BM, Khuntia D, Bentzen SM, Geye HM, Hayes LL, Kuo JS, Baskaya MK, Badie B, Basavatia A, Pyle GM, Tome WA, Mehta MP “Single institution experience treating 104 vestibular schwannomas with fractionated stereotactic radiation therapy or stereotactic radiosurgery.” Journal of Neuro-Oncology 116 (1): 187-93 (published online October 20, 2013) PMID 24142200. |
| 69 | Voss J, Meier TB, Freidel R, Kundu B, Nair VA, Holdsworth R, Kuo JS, Prabhakaran V “The role of secondary motor and language cortices in morbidity and mortality: A retrospective fMRI study of surgical planning for patients with intracranial tumors.” Neurosurgical Focus 34 (4): E7 (2013) PMID 23544413. PMCID: PMC3817821. |
| 70 | Kundu B, Penwarden A, Wood JM, Gallagher TA, Andreoli MJ, Voss J, Meier T, Nair VA, Kuo JS, Field AS, Moritz C, Meyerand ME, Prabhakaran V "Functional Magnetic Resonance Imaging indices are associated with postoperative language outcomes in primary brain tumor patients." Neurosurgical Focus 34 (4): E6 (2013) PMID 23544412. PMCID: PMC3954579. |
| 71 | Algharabli J, Kintner DB, Wang Q, Begum G, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D “Inhibition of Na+-K+-2Cl- cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells.” Cellular Physiology & Biochemistry 30: 33-48 (published online June 8, 2012) PMID 22759954. PMCID PMC3603147. |
| 72 | Clark PA, Treisman D, Iida M, Kalluri H, Ezhilan S, Zorniak M, Salamat S, Wheeler D, Kuo JS “Activation of multiple ERBB family receptors mediates glioblastoma cancer stem cell resistance to EGFR-targeted inhibition.” Neoplasia 14 (5): 420-8 (2012) PMID 22745588. PMCID PMC3384429. |
| 73 | Zorniak M, Clark PA, Leeper HE, Tipping M, Francis D, Kozak KR, Salamat MS, Kuo JS “Differential expression of 2’, 3’-cyclic nucleotide 3’-phosphodiesterase and neural lineage markers correlate with glioblastoma xenograft infiltration and patient survival.” Clinical Cancer Research 18 (13): 3628-36 (published online May 15, 2012) *highlighted article, also paired with CCR Translations commentary. PMID 22589395. PMCID PMC3597469. |
| 74 | Kruser TJ, Tome WA, Seo S, Kuo JS, Turski PA, Chappell RJ, Scrimger RA, Mehta MP “Prognostic factors for complete obliteration of arteriovenous malformations treated with LINAC-based stereotactic radiosurgery.” Journal of Radiosurgery & SBRT 1 (3): 203-11 (2011). PMID: 29296318. PMCID: PMC5725317. |
| 75 | Huang Y, Agrawal B, Clark PA, Williams, JC, Kuo JS “Evaluation of cancer stem cell migration using compartmentalizing microfluidic devices and live cell imaging.” Journal of Visualized Experiments 58: e3297 (published online December 23, 2011) PMID 22217858. PMCID: PMC3369664. |
| 76 | Ranganathan P, Clark PA, Kuo JS, Salamat MS, Kalejta RF “Significant association of multiple human cytomegalovirus genomic loci with glioblastoma multiforme biopsy samples.” Journal of Virology 86(2): 854-64 (2012, Published online November 16, 2011) PMID 22090104. PMCID PMC3255835. |
| 77 | Upton DC, Welham N, Kuo JS, Pasic T “Chronic rhinosinusitis with nasal polyps: a proteomic analysis.” Annals of Otology, Rhinology & Laryngology 120(12): 780-6 (2011) PMID 22279949. |
| 78 | Baggott C, Einstein MH, Miranpuri A, Rose SL, Kuo JS “What is the optimal venous thromboembolism prophylaxis for gynecological oncology patients with CNS metastases?” Gynecologic Oncology 123: 409-410 (2011) PMID 21807402. |
| 79 | Ebben J, Zorniak M, Clark PA, Kuo JS “Introduction to induced pluripotent stem cells: Advancing the potential for personalized medicine” World Neurosurgery 76 3/4: 270-275 (2011) *Top 3 downloaded paper for 2011 and 2012. PMID 21986423. |
| 80 | Wood J, Kundu B, Utter A, Gallagher T, Voss J, Nair VA, Kuo JS, Field A, Moritz C, Meyerand E, Prabhakaran V “Impact of brain tumor location on morbidity and mortality: A retrospective fMRI study.” American Journal of Neuroradiology 32:1420-25 (September 1, 2011) PMID 21885713. PMCID: PMC3305992. |
| 81 | Miranpuri A, Rajpal S, Salamat S, Rose S, Kuo JS “Intramedullary spinal metastasis originating from ovarian carcinoma – case report and review of literature” Journal of Medical Case Reports 5:311 (2011) PMID 21756304. PMCID: PMC3154862. |
| 82 | Huang Y, Agrawal B, Sun D, Kuo JS, Williams J “Microfluidics analysis of brain tumors and cancer stem cells.” Biomicrofluidics 5(1): 13412. (2011; published online March 30, 2011, *Top downloaded paper of April and May 2011, Top 20 downloaded paper from April 2011 to May 2012. PMID 21522502. PMCID: PMC3082349. |
| 83 | Thomas S, Mehta M, Kuo JS, Robins HI, Khuntia D “Current practices of driving restriction implementation for patients with brain tumors.” Journal of Neuro-Oncology, published online Oct 23, 2010) PMID 20598457. |
| 84 | Rocque BG, Kuo JS, Dempsey RJ “The University of Wisconsin Department of Neurological Surgery.” Neurosurgery 67 (2): 424-430 (2010) PMID 20644429. |
| 85 | Gondi V, Tolakanahalli R, Mehta MP, Tewatia D, Rowley H, Kuo JS, Khuntia D, Tome W “Hippocampal-sparing whole brain radiotherapy: A “How to” technique, utilizing helical tomotherapy and LINAC-based intensity modulated radiotherapy.” International Journal of Radiation Oncology, Biology & Physics 78 (4): 1244-52 (2010, published online June 30, 2010) PMID 20598407. PMCID: PMC2963699. |
| 86 | Ebben JD, Treisman DM, Zorniak M, Kutty RG, Clark PA, Kuo JS “The cancer stem cell paradigm: a new understanding of tumor development and treatment.” Expert Opinion in Targeted Therapies 14 (6): 621-632 (2010) PMID 20426697. PMCID: PMC3657606. |
| 87 | Gondi V, Tome WA, Marsh J, Struck A, Ghia A, Turian JV, Bentzen SM, Kuo JS, Khuntia D, Mehta MP “Estimated risk of peri-hippocampal disease progression after hippocampal avoidance during whole brain radiotherapy: Safety profile for RTOG 0933.” Radiotherapy & Oncology 95 (3): 327-31 (2010, published online April 12, 2010) PMID 20392503. PMCID: PMC2981132. |
| 88 | Kuo JS, Hawkins C, Rutka JT, Weiss MH “A pilot study of fat allograft transplantation in immunocompetent rabbits for potential neurosurgical applications.” Journal of Neurosurgery 114 (2): 441-5 (2011, published online December 4, 2009) PMID 19961319. |
| 89 | Kulstad R, Kuo JS, Shenker Y “Giant prolactinoma” Endocrine Practice 15 (2): 174 (2009) PMID 19289331. |
| 90 | Rocque BG, Herold KAG, Salamat MS, Shenker Y, Kuo JS “Symptomatic hyperprolactinemia from an ectopic pituitary adenoma located in the clivus.” Endocrine Practice 15 (2): 143-8 (2009). PMID 19289326. |
| 91 | Ebben J, Rocque BG, Kuo JS “Tumor vaccine approaches for CNS malignancies: Progress to date” - Leading Review for Drugs 69 (3): 241-9 (2009) PMID 19275269. |
| 92 | Kuo JS, Yu C, Petrovich Z, Apuzzo ML “The CyberKnife stereotactic radiosurgery system: description, installation, and an initial evaluation of use and functionality.” Neurosurgery 62 Suppl 2: 785-9 (2008) PMID 18596427. |
| 93 | Clark PA, Treisman D, Ebben J, Kuo JS “Developmental signaling pathways in brain tumor stem cells.” Developmental Dynamics 236 (12): 3297-3308 (2007) PMID 18000980. |
| 94 | Ghia A, Tomé WA, Thomas S, Cannon G, Khuntia D, Kuo JS, Mehta MP “Distribution of brain metastases in relation to the hippocampus: implications for neurocognitive functional preservation.” International Journal of Radiation Oncology, Biology & Physics 68 (4): 971-7 (2007, published online April 18, 2007) PMID 17446005. |
| 95 | Kuo JS, Gonzalez-Gomez I, McComb JG “Unexpected myxopapillary ependymoma within a filum terminale tethering the spinal cord: a case report.” Pediatric Neurosurgery 43 (4): 309-11 (2007) PMID 17627148. |
| 96 | Kuo JS and Tu C “Convection-enhanced delivery: an emerging technique for outwitting the blood-brain barrier in CNS therapy.” Formosan Journal of Surgery 39:216-221 (2006). |
| 97 | Rutka JT and Kuo JS “Pediatric surgical neuro-oncology: current best care practices and strategies.” AANS/CNS Section on Tumors, 20th Anniversary Special Issue, Journal of Neuro-oncology 69 (1-3): 139-50 (2004) PMID 15527086. |
| 98 | Rutka JT, Kuo JS, Carter M, Ray A, Ueda S, Mainprize TG “Advances in the surgical treatment of pediatric brain tumors.” Expert Reviews in Neurotherapeutics 4 (5): 879-93 (2004) PMID 15853514. |
| 99 | Kuo JS, Yu C, Giannotta SL, Petrovich Z, Apuzzo MLJ “The Leksell Gamma Knife Model U versus Model C: a quantitative comparison of radiosurgical treatment parameters.” Neurosurgery 55 (1): 168-73 (2004) PMID 15214986. |
| 100 | Kuo JS, Chen JCT, Yu C, Giannotta SL, Zelman V, Petrovich Z, MacPherson D, Apuzzo MLJ “Gamma knife radiosurgery of benign cavernous sinus tumors: quantitative analysis of outcomes.” Neurosurgery 54 (6): 1385-94 (2004) PMID 15157295. |
| 101 | Yokota N, Mainprize TG, Taylor MD, Kohata T, Loreto M, Ueda S, Dura W, Grajkowska W, Kuo JS, Rutka JT “Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization.” Oncogene 23: 3444-53 (2004) PMID 15064731. |
| 102 | Kuo JS and Rutka JT “Advances in understanding the molecular biology of brain tumors.” Journal of Korean Neurosurgical Society 35 (1): 1-11 (2004). |
| 103 | Kuo JS, Yu C, Petrovich Z, Apuzzo MLJ “The CyberKnife stereotactic radiosurgery system: description, installation and an initial evaluation of use and functionality.” Neurosurgery 53 (5): 1235-9 (2003) PMID 14580294. |
| 104 | Kuo JS, Patel M, Gamse J, Merzdorf C, Liu X, Apekin V, Sive H “Opl: a zinc finger protein that regulates neural determination and patterning in Xenopus.” Development 125 (15): 2867-82 (1998) PMID 9655809. |
| 105 | Kuo JS “Cloning and functional analysis of early neural determination genes in Xenopus.” PhD thesis, Dept. of Biology, Massachusetts Institute of Technology (1998). |
| 106 | Kuo JS, Veale R, Maxwell B, Sive H “Translational inhibition by 5’-polycytidine tracts in Xenopus embryos and in vitro.” Gene 176: 17-21 (1996) PMID 8918225. |
| 107 | Bender JS, Kuo JS, Kleckner N “Genetic evidence against intramolecular rejoining of the donor molecule following IS10 transposition.” Genetics 128: 687-94 (1991) PMCID PMC1204543. |