Member » President

President Mien-Chie Hung

Contact

  • Office: 91 Hsueh-shih Road, Taichung 40402, TAIWAN
  • Tel: +886-4-22053366 EXT.1018
  • Fax: +886-4-22060248
  • E-mail: mhung@mail.cmu.edu.tw

 

Current Position

  • President, China Medical University (Taiwan) , 2019
  • Academician, Academia Sinica (Taiwan)

 

Education

  • National Taiwan University, Taipei, BS, 1973, Chemistry
  • National Taiwan University, Taipei, MS, 1977, Biochemistry
  • Brandeis University, Waltham, MA, PHD, 1983, Biochemistry (Mentor: Pieter C. Winsink, Ph.D.)

 

Professional Experiences

Professional Experiences
  • Professor, The University of Texas M.D. Anderson Cancer Center, TX, 09/94-02/17/19    
  • Department Chair, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2000−02/17/19
  • Director, Center for Biological Pathways, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008−02/17/19
  • Vice President for Basic Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2010−02/17/19
  • Ruth Legett Jones Distinguished Chair, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2003−02/17/19 Ruth Legett Jones

 

Awards and Honors

Awards and Honors
  • John P. McGovern Outstanding Teacher Award University of Texas Health Science Center-Houston (1990, 1993, 1999, 2018), the only faculty receives this award four times.
  • Faculty Achievement Award in Education (1993) and in Basic Research (1998, 2017), The University of Texas M. D. Anderson Cancer Center.
  • Member, Pathology B Study Section (1996 – 2000) and Sub-committee C (2001-2005), NIH.
  • Founding Editorial Board, Cancer Cell 2001-present
  • Editor-in-Chief, American Journal For Cancer Research 2015-2017
  • Reappointed with the Highest Commendation by the Membership Committee, GSBS, 2005 & 2016 (five-year period)
  • Senior Editor, Cancer Research, American Association for Cancer Research (2018-2021)
  • Academician of the Academia Sinica, Taiwan (2002)
  • Member, The University of Texas Academy of Health Science Education.(2006)
  • Distinguished Teaching Professor, The University of Texas M. D. Anderson Cancer Center.(2007)
  • Full Member, Scientific Advisory Council, Susan G Komen.(2010-2016)
  • Fellow, section of Biological Sciences, American Association for the Advancement of Science.(2010)
  • Honorary President (life time), Breast Cancer Society of Taiwan(2010)
  • Presidential Award, Society of Chinese Bioscientists in America(2011)
  • The University of Texas M. D. Anderson Cancer Center LeMaistre Outstanding Achievement Award.(2011)
  • Outstanding Alumni Award, National Taiwan University, Taipei, Taiwan(2014)
  • Simiao Sun Award for Biomedical Achievement, Dalian Medical University Cancer Center, China
  • Co-Chair, 2017 AACR Annual Meeting Program Committee(2015-2017)
  • Lifetime Achievement Award, Society of Chinese Bioscientists in America(2017)
  • Regents’ Outstanding Teaching Award, The University of Texas System
  • Inaugural awardee of Breast Cancer Basic and Translational Research Outstanding Achievement Award, International Breast Cancer Stem Cell Symposium, Zhanjiang, Guangdong(2017)
  • Honorary Dean, West China School of Basic Medical Sciences & Forensic Medicine of Sichuan University, Chengdu, China(2018-2021)
  • President-elect, The University of Texas Academy of Health Science Education.(2018-2019)

 

Publications

SELECTED PUBLICATIONS

108 peer-reviewed publications which impact factor is 10 or above are selected from 520 publications (from 2000-present). Up to date, my lifetime h-index is 112. ORCID: 0000-0003-4317-4740

  • Xing, X., Wang, S-C., , Xia, W.Y.,  Zou, Y., Shao, R., Kwong, K.Y., Yu, Z., Zhang, S., Miller, S., Huang, L., and Hung, M.-C.  The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nature Medicine6:189-195, 2000.
  • Lin, S.-Y., Xia, W., Wang, J. C., Kwong, K-Y., Spohn, B., Wen, Y., Pestell, R.G. and Hung, M.-C.  b-catenin, a novel prognostic marker for breast cancer:  its roles in cyclin D1 expression and cancer progression. Proc. Natl. Acad. Sci. 97:4262-4266, 2000. 
  • Zhou, B.P., Liao, Y., Xia, W., Spohn, B., Lee, M.H., and Hung, M.-C.  Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nature Cell Biology 3(3):245-252, 2001.
  • Lin, S.Y., Makino, K., Xia, W., Matin, A., Wen, Y., Kwong, K.Y., Bourguignon, L., and Hung, M.-C.  Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nature Cell Biology 3:803-808, 2001.
  • Zhou, B.P., Liao, Y., Xia, W., Zou, Y., Spohn, B., and Hung, M.-C.  HER-2/neu induces ubiquitination via Akt-mediated MDM2 phosphorylation. Nature Cell Biology 3:973-982, 2001.
  • Hortobagyi, G.N., Ueno, N.T., Xia, W., Zhang, S., Wolf, J.W., Putnam, J.B., Weiden, P.L., Willey, J.S., Carey, M., Warner, D.L., Payne, J.Y., Tucker, S.D., Bartholomeusz, C., Kilbourn, R.G., De Jager, R.L., Sneige, N., Katz, R.L., Daifuku, R., Ibrahim, N.K., Murray, J.L., Theriault, R.L., Valero, V., Gershenson, D.M., Bevers, M.W., Huang, L., Lopez-Berestein, G. and Hung, M.-C.  Cationic liposome-mediated adenovirus type 5 E1A gene transfer to human breast and ovarian cancer cells and its biological effects: A phase I clinical trial. J. Clin. Oncol. 19:3422-3433, 2001.
  • Deng, J., Miller, S. A., Wang, H.-Y., Xia, W., Wen, Y., Zhou, B., Lin, S.-Y., Li, Yan and Hung, M.-C.  b-Catenin interacts with and inhibits NF-kB in human colon and breast cancers. Cancer Cell 2: 323-334,2002.
  • Tan, M., Jing, T., Lan, K.-H., Neal, C.L., Li, P., Lee, S., Fang, E., Nagata, Y., Liu, J., Arlinghaus, R., Hung, M.-C. and Yu, D.  Phosphorylation on tyrosine-15 of p34cdc2 by ErbB2 inhibits p34Cdc2 activation and is involved in resistance to Taxol-induced apoptosis. Molecular Cell 9: 993-1004, 2002*. * Selected as a cover on May issue.
  • Asada, S., Choi, Y., Yamada, M., Wang, S.-C., Hung, M.-C., Qin, J. and Uesugi, M.  External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc. Natl. Acad. Sci. USA 99:12747-12752, 2002.
  • Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X.-M., Lardy, H., Huang, K.-E., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., Xing, L., Boyce, B.F., Hung, M-C., Zhang, S. and Chang, C.  Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc. Natl. Acad. Sci. USA 99: 13498-13503, 2002.
  • Feng, Z., Hu, W., Chen, J. X., Pao, A., Li, H., Rom, W. N., Hung, M.-C., Adair, G.M. and Tang, M.-S.  Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J. Natl. Cancer Inst. 94:1527-1536, 2002*. *Accompanied by Editorial “Etiology of the mutational spectrum of ras gene in human carcinomas” by Kelley, M. J. and Littman, S. J. J. Natl. Cancer Inst. 94:1516-1517, 2002. Accompanied by BBC news embargo “Carcinogen in cigarettes causes mutation linked to lung cancer” on October 14, 2002.
  • Hu, M.C-T, Lee, D.-F., Xia, W., Golfman, L., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S, Hanada, N., Saso, H., Kobayashi R. and Hung, MC.  IkB kinase promotes tumourigenesis through inhibition of Forkhead transcription factor FOXO3a. Cell 117:225-237, 2004.
  • Wang, S-C., Lien, H-C., Xia, W., Chen, I-F., Lo, H-W., Wang, Z., Ali-Seyed, M., Bartholomeusz, G., Ou-Yang, F., Giri, D.K. and Hung, MC.  Binding at and transactivation of COX-2 promoter by nuclear tyrosine kinase receptor ErbB2. Cancer Cell 6:251-261, 2004.
  • Zhou, B.P., Deng, J., Xia, W., Xu, J., Li, Y.M., Gundaz, M. and Hung, MC.  Dual regulation of Snail by GSK-3b-mediated phosphorylation in control of epithelial-mesenchymal transition. Nature Cell Biology6:931-940, 2004.
  • Nagata, Y., Lan, K-H., Zhou, X., Tan, M., Esteva, F.J., Sahin, A.A., Klos, K.S., Li, P., Monia, B.P., Nguyen, N.T., Hortobagyi, G.N., Hung, MC and Yu, D.  PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6:117-127, 2004*. *Accompanied by many news release—Nature online news: www.nature.com/news; CNN news on Aug. 23, 2004; NBC Universal news on Aug. 23, 2004; MD Anderson Special News Release, Aug. 23, 2004; National Post of Canada, Aug. 24, 2004; Cancer Biology and Therapy, Aug. 24, 2004; The World Journal-- New York, Aug. 24, 2004; BCN (BreastCancer.Net) News, Aug. 24, 2004; www.reutershealth.com. ; Medical Post- Toronto; Shingtao Daily (a Chinese news paper); and Houston Chronicle.
  • Li, Y.M., Pan, Y., Wei, Y., Cheng, X., Zhou, B., Tan, M., Zhou, X., Xia, W., Hortobagyi, G.N., Yu, D. and Hung, MC  Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell6:459-469, 2004.
  • Lo, H-W., Hsu, S-C., Ali-Seyed, M., Gunduz, M., Xia, W., Wei, Y., Bartholomeusz, G., Shih, J-Y.,and Hung, M-C.  Nuclear interaction of EGFR and STAT3 in the activation of iNOS/NO pathway. Cancer Cell 7:575-589, 2005.
  • Ding, Q., Xia W., Liu, J-C., Yang, J-Y., Lee, D-F., Xia, J., Bartholomeusz, Li, Y., Pan, Y., Li, Z., Bargou, RC., Qin, J., Lai, C-C., Tsai, F-J. Tsai, C-H. and Hung, M-C.  Erk1/2 associates with and primes GSK-3b for its inactivation resulting in upregulation of b-catenin. Molecular Cell 19:159-170, 2005.
  • Cha, T-L., Zhou, BP., Xia, W., Wu, Y., Yang, C-C., Chen, C-T., Ping, B. Otte, A.P. and Hung, M-C.  Akt-mediated phosphorylation of EZH2 augments methylation of lysine 27 in histone H3. Science 310:306-310, 2005.
  • Wang, S-C., Nakajima, Y., Yu, Y-L., Li, L-Y., Chen, C-T, Hawke, D., Kobayashi, R. and Hung, M-C.  Tyrosine phosphorylation controls protein stability of PCNA. Nature Cell Biology. 8:1359-1368, 2006.
  • Su, J-L., Yang, P-C., Shih, J-Y., Yang, C-Y., Wei, L-H., Hsieh, C-Y., Chou, C-H., Jeng, Y-M., Wang, M-Y., Chang, K-J., Hung, M-C. and Kuo, M-L.  The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 9:209-223, 2006.
  • Huang, W-C., Ju, T-K., *Hung, M-C. and *Chen, C-C. Phosphorylation of CBP by IKKa promotes cell growth by switching the binding preference of CBP from p53 to NF-kB. Molecular Cell26:75-87, 2007. *co-corresponding author.
  • Xie, X., Xia, W., Li, Z., Kuo, H-P.,Liu, Y., Li, Z., Ding, Q., Zhang, S., Spohn, W., Yang, Y., Wei, Y., Lang, J-Y., Evans, D.B., Chiao, P.J., Abbruzzese J.L. and Hung, M-C. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell, 12:52-65, 2007.
  • Lee, D-F., Kuo, H-P., Chen, C-T., Hsu, J-M., Sun, H-L., Chou, C-K., Wei, Y., Li, L-Y.,Ping, B., Huang, W-C., He, X., Hung, J-Y., Lai, C-C., Ding, Q., Su, J-L., Yang, J-Y., Sahin, A.A., Hortobagyi, G.N., Tsai, F-J., Tsai, C-H. and Hung, M-C. Suppression of TSC1 by IKKb confers tumor angiogenesis through the mTOR pathway. Cell130:440-455, 2007.
  • Wang, R-H., Zheng, Y., Kim, H-S., Xu, X., Cao, L., Luhasen, T., Lee, M-H., Xiao, C., Vassilopoulos, A., Chen, W., Gardner, K., Man, Y-G., Hung, M-C., Finkel, T. and Deng, C-X. Interplay among BRAC1, SIRT1 and Survivin during BRAC1-associated tumorigenesis. Molecular Cell, 32:11-20, 2008*. *Previews: “SIRTing through breast cancer is just a survivin’ game” by Jianyuan Luo and Dario C. Altieri, Molecular Cell 32:159-160, 2008.
  • Kang, T., Wei, Y., Honaker, Y., Yamaguchi, H., Appella, E., Hung, M-C. and Piwnica-Worms, H.  GSK-3β targets Cdc25A for ubiquitin-mediated proteolysis and GSK-3β inactivation leads to Cdc25A overproduction in human cancers. Cancer Cell 13: 36-47, 2008.
  • Yang, J-Y., Zong, C.S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J-Y., Lai, C-C., Chang, C-J., Huang, W-C., Huang, H., Kuo, H-P., Lee, D-F., Li, L-Y., Lien H-C., Cheng, X, Chang, K-J., Hsiao, C-D., Tsai, F-J., Tsai, C-H., Sahin, AA., Muller, WJ., Mills, GB., Yu, D., Hortobagyi, GN. and Hung, M-C. Erk promotes tumorigenesis by inhibiting Foxo3a via MDM2-mediated degradation. Nature Cell Biology10:138-148, 2008.
  • Zhang, W., Tsan, R., Wu, Q., Huang, W-C., Chiu, C-H., *Fidler, I.J. and *Hung, M-C. Survival of cancer cells is maintained by kinase-independent EGFR. Cancer Cell 13:383-393, 2008. *Co-Corresponding authors.
  • Lee, D-F., Kuo, H-P., Liu, M., Chou, C-K., Xia, W., Du, Y., Shen, J., Shen, J., Chen, C-T., Huo, L., Hsu, M-C., Li, C-W., Ding, Q., Liao, T-L., Lai, C-C., Lin, A-C. Chang, Y-H, Tsai, S-F., Li, L-Y. and Hung, M-C. KEAP1 E3 ligase-mediated down regulation of NF-kB signaling by targeting IKKb. Molecular Cell 36: 131-140, 2009.
  • Liu, S., Umezu-Goto, M., Murph, M., Lu, Y., Liu, W., Zhang, F., Yu, S., Stephens, L.C., Cui, Z., Murrow, G., Coombes, K., Muller, W., Hung, M-C., Perou, C. M., Lee, A. V., Fang, X. and Mills, G. B. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion and metastasis. Cancer Cell 15:539-550, 2009.
  • Lu, J, Guo, H, Treekitkarnmongkol, W, Li, P, Zhang, J, Shi, B, Ling C, Zhou, X, Chen, T, Chiao, P, Feng X, Seewaldt, V, Muller, W, Sahin, A, Hung, M-C and Yu, D. 14-3-3ζ cooperates with ErbB2 to promote progression of ductal carcinoma in situ to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell 16:195-207, 2009.
  • Hildebrandt, MAT., Yang, H., Hung, M-C., Izzo, JG., Huang, M., Lin, J., Ajani, JA and Wu, X. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. Journal of Clinical Oncology27:857-871 (Epub Jan 21), 2009.
  • Jiralerspong, S., Palla, S., Girodano, S., Meric-Bernstam, F., Liedtke, C., Barnett, C., Hsu, L. Hung, M-C., Hortobagyi, G and Gonzalez-Angulo, A.M. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. Journal of Clinical Oncology (Epub June 1), 27: 3297-3302, 2009.
  • Lu C., Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MMK, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung M-C, Lopez-Berestien G, Sood AK. Regulation of tumor angiogenesis by EZH2. Cancer Cell 18 (2): 185-197, 2010.
  • Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT, Mills GB, Hortobagyi GN, Mendelsohn J, Hung MC, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated activation of Src and inactivation of PTEN. Cancer Cell 18:423-435, 2010.
  • Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung M-C, Pandolfi PP and Lin HK. Deciphering the transcription complex critical for RhoA gene expression and cancer metastasis. Nature Cell Biology, 12(5): 457-467 (Epub online April 11), 2010.
  • Huo LF, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding QQ, Chen CH, Tsai CH, Hung M-C. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc. Natl. Acad. Sci.  107(37):16125-16130 (Epub online August 27), 2010.
  • Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cell. Nature Cell Biology13 (1):87-94(Epub online December 5, 2010), 2011.
  • Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a noncanonical histone signature to breast cancer. Nature Dec 16; 468(7326):927-932, 2010.
  • Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast cancer tumor initiating cells through activation of RAF-b-catenin signaling.  Cancer Cell 19 (1):86-100, (Epub online Jan 5), 2011.
  • Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between R1175 methylation and Y1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nature Cell Biology13(2):174-181, (Epub online Jan 23), 2011.
  • Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu J, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition (EMT) and stem cell properties through modulation of miRNAs. Nature Cell BiologyMar;13(3):317-323 (Epub online Feb 20), 2011.
  • Tsai KS, Yang SH, Lei YP, Tsai CC, Chen HW, Hsu CY, Chen LL, Wang HW, Miller SA, Chiou SH, *Hung MC and *Hung SC. Mesenchymal stem cells within tumors enhance xenograft tumor formation in colorectal cancer.  GastroenterologySep;141(3):1046-1056 (Epub online May 31), 2011. *Co-corresponding authors
  • Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC Jr. Dasatinib-enhanced paclitaxel cytotoxicity by upregulation of p27Kip1 and downregulation of Bcl-2 and CDK1. JNCI Sep 21;103(18):1403-1422 (Epub online August 2), 2011.
  • Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell Sep 13;20(3):341-356, 2011.
  • Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai CC, Li HB, Yen CJ, Kuo HP, Lee DF, Lang JY, Huo LF, Cheng XY, Chen YJ, Li CW, Jeng LB, Hsu J, Li LY, Tan A, Curley SA, Ellis LM, DuBois RN and Hung MC. Genes that mediate colorectal cancer metastasis to liver. Journal of Clinical Investigation Nov 1;121(11):4526-4536 (Epub online Oct 10), 2011.
  • Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC.  IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Molecular Cell 45(2):171-184 (Epub on line Dec 20, 2011), 2012.
  • Wang Y, Ding QQ, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Miller SA, Wang X, Lee DF, Hsu JL, Hsu JM, Huo LF, LaBaff AM, Liu DP, Huang TH, Lai CC, Tsai FJ, Chang WC, Chen CH, Wu TT, Buttar NS, Wang KK, Wu Y, Wang H, Ajani J, Hung MC. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell 21, 374–387 (DOI 10.1016/j.ccr.2011.12.028), 2012.
  • Ling J, Kang Y, Lee D-F, Xia Q, Zhao R, Chang Z, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/b/NF-kB activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell Jan 17, 21:105-120, 2012.
  • Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH. Rac1 activation mediates Twist1-induced cancer cell migration. Nature Cell Biology 14:366-374, (Epub March 11, doi: 10.1038/ncb2455), 2012. PMID: 22407364.
  • Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KC, Flores LG, Shao Y, Hazel JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama K, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis. Cell 149:1098-1111, 2012.
  • Lee DF, Su J, Ang YS Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJK, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moor KA, Snoeck HW, Ma’ayan A, Schaniel C, Lemischka IR. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell Aug 3, 11(2):179-194, 2012.
  • Chen D, Su Y, Wei Y, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nature Medicine 18(10):1511-1517, (EPub online Sept 23), 2012.
  • Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O’Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 de-stabilization. Genes and Development 27(3):274-287, 2013.
  • Dong C, Yuan T, Wu Y, Wang Y, Fan TWM, Miriyala S, Lin Y, Yao J, Shi J, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of RBP1 by snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell (Epub online Feb 7, doi:pii: S1535-6108(13)00042-1. 10.1016/j.ccr.2013.01.022), 2013.
  • Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim SO, Du Y, Wang Y, Chang WC, Chen CH, Hsu JL, Wu Y, Lam YC, James BP, Liu X, Liu CG, Patel DJ, Hung MC.  EGFR modulates miRNA maturation in response to hypoxia through phosphorylation of Ago 2. Nature May 16; 497(7449):383-387 (epub online May 1, doi: 10.1038/nature12080.), 2013.
  • News in Cancer Discovery “EGFR Regulates microRNA Processing via Modification of AGO2”, May 9, 2013 (DOI: 10.1158/2159-8290.CD-RW2013-099);
  • “MICRORNA Lacking in Maturity” Nicola McCarthy, Nature Reviews Cancer (published online 16 May 2013; doi:10.1038/nrc3534)
  • Editor’s Choice “Hypoxia Prevents miRNA Processing” Nancy R. Gough, Science Signaling 21 May, 2013 Vol 6, Issue 276, p. ec111 (doi: 10.1126/scisignal.2004336)
  • Chan CH, Morrow JK, Li CF, GaoY, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis C, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cells and cancer progression. Cell 154:556-568, 2013.
  • Wagner K, Alam H, Dhar S, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani A, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach J, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling in NSCLC. Journal of Clinical Investigation 123 (12): 5231-5246, (pii: 68642. doi: 10.1172/JCI68642. Epub online Nov 8), 2013.
  • Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitination and stabilization of PTEN by USP13. Nature Cell Biology Dec; 15(12):1486-1494 (doi:10.1038/ncb2874, Epub Nov 24), 2013.
  • Huang TH, Huo LF, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, Shen J, Lee HH, Lee PC, Wu Y, Chen CH, Hung MC. EGFR potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell 23(6):796-810, 2013.
  • Chiou GY, Chien CS, Wang ML, Chen MT, Yang YP, Yu YL, Chien Y, Chang YC, Shen CC, Chio CC, Lu KH, Ma HI, Chen KH, Liu DM, Miller SA, Chen YW, Huang PI, Shin YH, *Hung MC, *Chiou SH. Epigenetic regulation of the MiR142-3p/Interleukin-6 circuit in glioblastoma.  Molecular Cell Dec 12; 52(5):693-706, (doi:10.10.16/j.molcel,2013.11.009), 2013. *Co-corresponding authors
  • Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Kuo SC, Chen CH, Yu YL*, Hung MC*. EGFR modulates DNA synthesis and repairs through Tyr phosphorylation of Histone H4. Development Cell 30(2):224-237, (doi: 10.1016/j.devcel.2014.06.008), 2014. *co-corresponding authors.
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