Member » Vice-President

Vice President Fuu-Jen Tsai

Vice President Fuu-Jen Tsai

Vice President Fuu-Jen Tsai

Contact

  • Office: 91 Hsueh-Shih Road, Taichung, 40402, TAIWAN
  • TEL: +886-4-22053366 ext. 1015; 886-4-22052121 ext. 2041
  • Fax: +886-4-22033295
  • E-mail: d0704@mail.cmuh.org.tw
  • Seceretary: Yi-Yin Wang

 

PROFESSIONAL SOCIETIES

  • American Society of Human Genetics
  • European Society of Human Genetics

 

Education

Year Education
1978/9~1985/7 MD, China Medical College, Taichung, Taiwan
1993/9~1997/6 Ph.D., Institute of Chinese Medicine, China Medical College

 

Employment

Year Employment
1998~ Present Chief, Department of Medical Genetics, China Medical University Hospital
2001/3~2003/10 Chief, Department of Pediatrics, China Medical University Hospital
2001/10~Present Professor of Pediatrics, China Medical University
2002/3~2005/3 President, Taiwan Human Genetics Society
2003/10~2009/10 Dean, College of Chinese Medicine China Medical University
2006/8~Present Chief, Genetic Center China Medical University Hospital

 

Publications

“Kawasaki disease”Related Publications
Lee YC, Kuo HC, Chang JS, Chang LY, Huang LM, Chen MR, Liang CD, Chi H, Huang FY, Lee ML, Huang YC, Hwang B, Chiu NC, Hwang KP, Lee PC, Chang LC, Liu YM, Chen YJ, Chen CH; Taiwan Pediatric ID Alliance, Chen YT, Tsai FJ*, Wu JY. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet. 2012 Mar 25;44(5):522-5.
Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML; Hong Kong–Shanghai Kawasaki Disease Genetics Consortium, Lau YL, Zhang J, Ma XJ, Liu F, Wu L; Korean Kawasaki Disease Genetics Consortium, Yoo JJ, Hong SJ, Kim KJ, Kim JJ, Park YM, Hong YM, Sohn S, Jang GY, Ha KS, Nam HK, Byeon JH, Yun SW, Han MK, Lee KY, Hwang JY, Rhim JW, Song MS, Lee HD, Kim DS, Lee JM; Taiwan Kawasaki Disease Genetics Consortium, Chang JS, Tsai FJ, Liang CD, Chen MR, Chi H, Chiu NC, Huang FY, Chang LY, Huang LM, Kuo HC, Huang KP, Lee ML, Hwang B, Huang YC, Lee PC; International Kawasaki Disease Genetics Consortium, Odam M, Christiansen FT, Witt C, Goldwater P, Curtis N, Palasanthiran P, Ziegler J, Nissen M, Nourse C, Kuipers IM, Ottenkamp JJ, Geissler J, Biezeveld M, Tacke C, Filippini L, Brogan P, Klein N, Shah V, Dillon M, Booy R, Shingadia D, Bose A, Mukasa T, Tulloh R, Michie C; US Kawasaki Disease Genetics Consortium, Newburger JW, Baker AL, Rowley AH, Shulman ST, Mason W, Takahashi M, Melish ME, Tremoulet AH; Blue Mountains Eye Study, Viswanathan A, Rochtchina E, Attia J, Scott R, Holliday E, Harrap S. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet. 2011 Nov 13;43(12):1241-6.
Lin YJ, Chang JS, Liu X, Hung CH, Lin TH, Huang SM, Jeang KT, Chen CY, Liao CC, Lin CW, Lai CH, Tien N, Lan YC, Ho MW, Chien WK, Chen JH, Huang YC, Tsang H, Wu JY, Chen CH, Chang LC, Tsai FJ*. Association between GRIN3A Gene Polymorphism in Kawasaki Disease and Coronary Artery Aneurysms in Taiwanese Children. PLoS One. 2013 Nov 22;8(11):e81384. 
Lin YJ, Chang JS, Liu X, Lin TH, Huang SM, Liao CC, Lin CW, Chien WK, Chen JH, Wu JY, Chen CH, Chang LC, Tsang H, Jeang KT, Chen CY, Tsai FJ*. Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients. Cell & Bioscience 2013, 3:44.
Tsai FJ, Lee YC, Chang JS, Huang LM, Huang FY, Chiu NC, Chen MR, Chi H, Lee YJ, Chang LC, Liu YM, Wang HH, Chen CH, Chen YT, Wu JY. Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study. PLoS One. 2011 Feb 4;6(2):e16853.
Lin YJ, Wan L, Wu JY, Sheu JJ, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin TH, Lin JG, Hsueh KC, Huang YM, Chang JS, Tsai FJ*.HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. Arthritis Rheum. 2009; 60(2):604-10.
Chang CJ, Kuo HC, Chang JS, Lee JK, Tsai FJ, Khor CC, Chang LC, Chen SP, Ko TM, Liu YM, Chen YJ, Hong YM, Jang GY, Hibberd ML, Kuijpers T, Burgner D, Levin M, Burns JC, Davila S; International Kawasaki Disease Genetics Consortium; Korean Kawasaki Disease Genetics Consortium; Taiwan Kawasaki Disease Genetics Consortium, Chen YT, Chen CH, Wu JY, Lee YC. Replication and meta-analysis of GWAS identified susceptibility loci in kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility. PLoS One. 2013 Aug 30;8(8):e72037.   
Hsieh YY, Chang CC, Hsu CM, Chen SY, Lin WH, Tsai FJ*. Major histocompatibility complex class I chain-related gene polymorphisms: associated with susceptibility to Kawasaki disease and coronary artery aneurysms. Genet Test Mol Biomarkers. 2011 Nov;15(11):755-63.
Hsieh YY, Lin YJ, Chang CC, Chen DY, Hsu CM, Lo MM, Hsu KH, Tsai FJ*.  Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm. J Clin Lab Anal. 2010; 24(4):262-8.
Huang YC, Lin YJ, Chang JS, Chen SY, Wan L, Sheu JJ, Lai CH, Lin CW, Liu SP, Chen CP, Tsai FJ*.  Single nucleotide polymorphism rs2229634 in the ITPR3 gene is associated with the risk of developing coronary artery aneurysm in children with Kawasaki disease.  Int J Immunogenet. 2010; 37(6):439-43. 
Sheu JJ, Lin YJ, Chang JS, Wan L, Chen SY, Huang YC, Chan C, Chiu IW, Tsai FJ*.  Association of COL11A2 polymorphism with susceptibility to Kawasaki disease and development of coronary artery lesions.  Int J Immunogenet. 2010; 37(6):487-92. 
Hsueh KC, Lin YJ, Chang JS, Wan L, Tsai FJ*.  BTNL2 gene polymorphisms may be associated with susceptibility to Kawasaki disease and formation of coronary artery lesions in Taiwanese children.  Eur J Pediatr. 2010; 169(6):713-9. 
Hsueh KC, Lin YJ, Chang JS, Wan L, Tsai YH, Tsai CH, Chen CP, Tsai FJ*. Association of interleukin-10 A-592C polymorphism in Taiwanese children with Kawasaki disease.  J Korean Med Sci. 2009; 24(3):438-42.  
Chen SY, Wan L, Huang YC, Sheu JJ, Lan YC, Lai CH, Lin CW, Chang JS, Tsai Y, Liu SP, Lin YJ, Tsai FJ*.  Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease.  J Clin Lab Anal. 2009; 23(2):71-6. 
Hsueh KC, Lin YJ, Chang JS, Wan L, Tsai YH, Tsai CH, Tsai FJ*.  Influence of interleukin 18 promoter polymorphisms in susceptibility to Kawasaki disease in Taiwan.  J Rheumatol. 2008; 35(7):1408-13.
Hsueh KC, Lin YJ, Chang JS, Wan L, Tsai YH, Tsai CH, Chen CP, Tsai FJ*.Association of vascular endothelial growth factor C-634 g polymorphism in taiwanese children with Kawasaki disease.    Pediatr Cardiol. 2008; 29(2):292-6. 
Wu SF, Chang JS, Wan L, Tsai CH, Tsai FJ*. Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease. J Clin Lab Anal. 2005;19(3):99-102.
Wu SF, Chang JS, Peng CT, Shi YR, Tsai FJ*. Polymorphism of angiotensin-1 converting enzyme gene and Kawasaki disease. Pediatr Cardiol. 2004 Sep-Oct;25(5):529-33.
“Wilson disease” Related Publications
 Wan L, Tsai CH, Hsu CM, Huang CC, Yang CC, Liao CC, Wu CC, Hsu YA, Lee CC, Liu SC, Lin WD, Tsai FJ*.  Mutation analysis and characterization of alternative splice variants of the Wilson disease gene ATP7B.  Hepatology. 2010; 52: 1662-70. 
 Lin CW, Er TK, Tsai FJ, Liu TC, Shin PY, Chang JG.  Development of a high-resolution melting method for the screening of Wilson disease-related ATP7B gene mutations.  Clin Chim Acta. 2010; 6; 411(17-18):1223-31.
Wan L, Tsai CH, Tsai Y, Hsu CM, Lee CC, Tsai FJ*.  Mutation analysis of Taiwanese Wilson disease patients. Biochem Biophys Res Commun. 2006; 30; 345(2):734-8.
 Lin CW, Er TK, Tsai FJ, Liu TC, Shin PY, Chang JG. Development of a high-resolution melting method for the screening of Wilson disease-related ATP7B gene mutations. Clin Chim Acta. 2010 Sep 6;411(17-18):1223-31.
 Lee CC, Wu JY, Tsai FJ, Kodama H, Abe T, Yang CF, Tsai CH. Molecular analysis of Wilson disease in Taiwan: identification of one novel mutation and evidence of haplotype-mutation association. J Hum Genet. 2000;45(5):275-9.
Tsai CH, Tsai FJ, Wu JY, Chang JG, Lee CC, Lin SP, Yang CF, Jong YJ, Lo MC. Mutation analysis of Wilson disease in Taiwan and description of six new mutations. Hum Mutat. 1998;12(6):370-6.
“Type 2 diabetes” related publications
Lin HJ, Huang YC, Lin JM, Liao WL, Wu JY, Chen CH, Chou YC, Chen LA, Lin CJ, Tsai FJ*. Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. Ophthalmic Genet. 2012 Nov 9.
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Feb 9. doi: 10.1038/ng.2897.
Lin HJ, Huang YC, Lin JM, Wu JY, Chen LA, Tsai FJ*. Association of Genes on Chromosome 6, GRIK2 , TMEM217 and TMEM63B (Linked to MRPL14) with Diabetic Retinopathy. Ophthalmologica. 2012 Sep 28.
Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, Guo K, Zuo X, Guo X, Yang H, Zhou X; DIAGRAM Consortium; AGEN-T2D Consortium, Zhang X, Qi L, Loos RJ, Hu FB, Wu T, Liu Y, Liu L, Yang Z, Hu R, Jia W, Ji L, Li Y, Lin X. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes. 2013 Jan;62(1):291-8.
Xi B, Takeuchi F, Chandak GR, Kato N, Pan HW; AGEN-T2D Consortium, Zhou DH, Pan HY, Mi J. Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals. Diabetologia. 2012 Oct;55(10):2660-6.
Hsieh YY, Huang YC, Chang CC, Wang YK, Lin WH, Tsai FJ*. Chromosome 15q21-22-related polymorphisms and haplotypes are associated with susceptibility to type-2 diabetic nonproliferative retinopathy. Genet Test Mol Biomarkers. 2012 May;16(5):442-8.
Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee JJ, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DP, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman ÅK, Morris AP, McCarthy MI; DIAGRAM Consortium; MuTHER Consortium, Takayanagi R, Park KS, Jia W, Chuang LM, Chan JC, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, Seielstad M. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011 Dec 11;44(1):67-72.
Liao WL, Chen CC, Chang CT, Wu JY, Chen CH, Huang YC, Tsai CH, Tsai FJ*. Gene polymorphisms of adiponectin and leptin receptor are associated with early onset of type 2 diabetes mellitus in the Taiwanese population. Int J Obes (Lond). 2012 Jun;36(6):790-6.
Huang YC, Lin JM, Lin HJ, Chen CC, Chen SY, Tsai CH, Tsai FJ*. Genome-wide association study for diabetic retinopathy in a Taiwanese population. Ophthalmology. 2011 Apr;118(4):642-8.
Tsai FJ, Yang CF, Chen CC, Chuang LM, Lu CH, Chang CT, Wang TY, Chen RH, Shiu CF, Liu YM, Chang CC, Chen P, Chen CH, Fann CS, Chen YT, Wu JY.  A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 2010; 6(2):e1000847. 
Lin HJ, Huang YC, Lin JM, Wu JY, Chen LA, Lin CJ, Tsui YP, Chen CP, Tsai FJ*.  Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of Type 2 diabetes with cataract. Mol Vis. 2010; 16:1206-14.
Kuo WW, Chung LC, Liu CT, Wu SP, Kuo CH, Tsai FJ, Tsai CH, Lu MC, Huang CY, Lee SD.  Effects of insulin replacement on cardiac apoptotic and survival pathways in streptozotocin-induced diabetic rats.  Cell Biochem Funct. 2009; 27(7):479-87. 
Chen CC, Wu JY, Chang CT, Tsai FJ, Wang TY, Liu YM, Tsui HC, Chen RH, Chiou SC.  Levels of retinol-binding protein 4 and uric acid in patients with type 2 diabetes mellitus.  Metabolism. 2009; 58(12):1812-6.

*Corresponding author

 

Books

Books
1998 小兒完全健康手冊
2002 與基因共舞:遺傳疾病淺說